GB0600122D0 - Mutation in the growth hormone receptor - Google Patents

Mutation in the growth hormone receptor

Info

Publication number
GB0600122D0
GB0600122D0 GBGB0600122.6A GB0600122A GB0600122D0 GB 0600122 D0 GB0600122 D0 GB 0600122D0 GB 0600122 A GB0600122 A GB 0600122A GB 0600122 D0 GB0600122 D0 GB 0600122D0
Authority
GB
United Kingdom
Prior art keywords
exon
ghr
growth hormone
hormone receptor
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0600122.6A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Cardiff Consultants Ltd
Cardiff University
Original Assignee
University College Cardiff Consultants Ltd
Cardiff University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Cardiff Consultants Ltd, Cardiff University filed Critical University College Cardiff Consultants Ltd
Priority to GBGB0600122.6A priority Critical patent/GB0600122D0/en
Publication of GB0600122D0 publication Critical patent/GB0600122D0/en
Priority to GB0625887A priority patent/GB2433990A/en
Priority to TW095148940A priority patent/TW200734636A/en
Priority to PCT/GB2006/004923 priority patent/WO2007077425A2/en
Priority to ARP070100027A priority patent/AR059133A1/en
Priority to NL1033167A priority patent/NL1033167C2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A method for assaying for the exon 3 deletion in the growth hormone receptor (GHR) gene comprising amplification of the exon 3 region of GHR using proximal and distal primers and the detection of the transcribed product with a labeled hybridisation probe. Said probe is preferably a labeled oligonucleotide labeled with a light emitting molecule. The method may further include the steps of transcribing either another gene such a b -actin or exon 10 of GHR. Primers for the amplification reactions are disclosed and the method is exemplified by using quantitative PCR. Also disclosed is the use of the exon 3 deletion assay method to screen individuals for susceptibility to hypertension or stroke.
GBGB0600122.6A 2006-01-05 2006-01-05 Mutation in the growth hormone receptor Ceased GB0600122D0 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GBGB0600122.6A GB0600122D0 (en) 2006-01-05 2006-01-05 Mutation in the growth hormone receptor
GB0625887A GB2433990A (en) 2006-01-05 2006-12-23 Exon 3 mutation of the growth hormone receptor
TW095148940A TW200734636A (en) 2006-01-05 2006-12-26 Mutation in the growth hormone receptor
PCT/GB2006/004923 WO2007077425A2 (en) 2006-01-05 2006-12-27 Mutation in the growth hormone receptor
ARP070100027A AR059133A1 (en) 2006-01-05 2007-01-03 MUTATION IN THE RECEIVER OF THE HORMONE OF GROWTH
NL1033167A NL1033167C2 (en) 2006-01-05 2007-01-04 Mutation in the growth hormone receptor.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0600122.6A GB0600122D0 (en) 2006-01-05 2006-01-05 Mutation in the growth hormone receptor

Publications (1)

Publication Number Publication Date
GB0600122D0 true GB0600122D0 (en) 2006-02-15

Family

ID=35911401

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB0600122.6A Ceased GB0600122D0 (en) 2006-01-05 2006-01-05 Mutation in the growth hormone receptor
GB0625887A Withdrawn GB2433990A (en) 2006-01-05 2006-12-23 Exon 3 mutation of the growth hormone receptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB0625887A Withdrawn GB2433990A (en) 2006-01-05 2006-12-23 Exon 3 mutation of the growth hormone receptor

Country Status (5)

Country Link
AR (1) AR059133A1 (en)
GB (2) GB0600122D0 (en)
NL (1) NL1033167C2 (en)
TW (1) TW200734636A (en)
WO (1) WO2007077425A2 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641998B2 (en) * 1997-10-10 2003-11-04 Stratagene Methods and kits to enrich for desired nucleic acid sequences
AU2001274234A1 (en) * 2000-06-16 2001-12-24 Asterion Limited Binding agents: chimeric ligand/receptor proteins
US20030124512A1 (en) * 2000-10-18 2003-07-03 Lieven Stuyver Simultaneous quantification of nucleic acids in diseased cells
SE0300959D0 (en) * 2002-12-19 2003-04-02 Pharmacia Ab Methods for predicting therapeutic response to agents acting on the growth hormone receptor

Also Published As

Publication number Publication date
WO2007077425A3 (en) 2008-01-24
NL1033167C2 (en) 2008-02-20
NL1033167A1 (en) 2007-07-09
WO2007077425A2 (en) 2007-07-12
AR059133A1 (en) 2008-03-12
GB0625887D0 (en) 2007-02-07
TW200734636A (en) 2007-09-16
GB2433990A (en) 2007-07-11

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)