CA2446080C - Scalable inlet liquid distribution system for large scale chromatography columns - Google Patents
Scalable inlet liquid distribution system for large scale chromatography columns Download PDFInfo
- Publication number
- CA2446080C CA2446080C CA 2446080 CA2446080A CA2446080C CA 2446080 C CA2446080 C CA 2446080C CA 2446080 CA2446080 CA 2446080 CA 2446080 A CA2446080 A CA 2446080A CA 2446080 C CA2446080 C CA 2446080C
- Authority
- CA
- Canada
- Prior art keywords
- distribution
- slot
- cell
- distribution system
- radius
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000009826 distribution Methods 0.000 title claims abstract description 159
- 239000007788 liquid Substances 0.000 title claims abstract description 41
- 238000004587 chromatography analysis Methods 0.000 title claims description 8
- 239000012530 fluid Substances 0.000 claims abstract description 57
- 230000002093 peripheral effect Effects 0.000 claims description 12
- 239000012071 phase Substances 0.000 abstract description 6
- 239000007791 liquid phase Substances 0.000 abstract description 5
- 238000012546 transfer Methods 0.000 abstract description 2
- 238000012856 packing Methods 0.000 description 23
- 238000013461 design Methods 0.000 description 14
- 239000006185 dispersion Substances 0.000 description 12
- 238000000034 method Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 238000013375 chromatographic separation Methods 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011173 large scale experimental method Methods 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6017—Fluid distributors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/85938—Non-valved flow dividers
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0111486.7 | 2001-05-11 | ||
| GB0111486A GB0111486D0 (en) | 2001-05-11 | 2001-05-11 | Scalable inlet liquid distribution system for large scale chromatography columns |
| PCT/EP2002/005144 WO2002093159A2 (en) | 2001-05-11 | 2002-05-10 | Scalable inlet liquid distribution system for large scale chromatography columns |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2446080A1 CA2446080A1 (en) | 2002-11-21 |
| CA2446080C true CA2446080C (en) | 2010-09-14 |
Family
ID=9914412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2446080 Expired - Fee Related CA2446080C (en) | 2001-05-11 | 2002-05-10 | Scalable inlet liquid distribution system for large scale chromatography columns |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7051758B2 (enExample) |
| EP (1) | EP1393058B1 (enExample) |
| JP (1) | JP4263490B2 (enExample) |
| AU (1) | AU2002314053A1 (enExample) |
| CA (1) | CA2446080C (enExample) |
| GB (1) | GB0111486D0 (enExample) |
| WO (1) | WO2002093159A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0212513D0 (en) * | 2002-05-31 | 2002-07-10 | Amersham Biosciences Ab | Packing device and method for chromatography columns |
| DE102004043362A1 (de) * | 2004-09-08 | 2006-03-09 | Bayer Technology Services Gmbh | Flüssigkeitsverteiler und Flüssigkeitssammler für Chromatographiesäulen |
| FR2933000B1 (fr) * | 2008-06-27 | 2011-03-18 | Inst Francais Du Petrole | Nouveau systeme de distribution et de collecte dans une colonne multi etagee permettant d'egaliser les temps de sejour sur chaque etage |
| DE102009009703A1 (de) * | 2009-02-19 | 2010-08-26 | Andrea Claudia Walter | Chromatographievorrichtung |
| JP6342160B2 (ja) * | 2010-06-15 | 2018-06-13 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 流体分配器 |
| US20130001145A1 (en) * | 2011-06-29 | 2013-01-03 | Agilent Technologies, Inc. | Micro-Machined Frit and Flow Distributor Devices for Liquid Chromatography |
| CN103638692B (zh) * | 2013-11-29 | 2016-03-02 | 源创精科生物科技(长沙)有限公司 | 具有二级流道的层析柱的液体分配器 |
| FR3020964B1 (fr) | 2014-05-16 | 2021-11-12 | Novasep Process | Unite de distribution de fluide pour une colonne de chromatographie |
| FR3065173B1 (fr) * | 2017-04-12 | 2020-06-26 | IFP Energies Nouvelles | Nouveau dessin des canaux de collecte et de distribution pour un procede de separation en lit mobile simule utilisant n-colonnes en serie |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH503985A (de) * | 1968-09-19 | 1971-02-28 | Ceskoslovenska Akademie Ved | Verfahren und Einrichtung zur Trennung eines Hauptmediums von einem Strom, der durch einzelne Abschnitte des Hauptmediums und eines Trennmediums gebildet wird |
| US4423982A (en) * | 1980-12-08 | 1984-01-03 | Standard Oil Company (Indiana) | Method and equipment for running riser pipes for mooring offshore floating platforms |
| US4537217A (en) * | 1982-12-09 | 1985-08-27 | Research Triangle Institute | Fluid distributor |
| US4743373A (en) * | 1983-06-17 | 1988-05-10 | Cuno Incorporated | Chromatography column |
| US4582608A (en) * | 1985-02-15 | 1986-04-15 | Separations Technology, Inc. | HPLC column |
| US4891133A (en) | 1987-09-15 | 1990-01-02 | Cerex Corporation | Chromatography apparatus |
| FR2632206B1 (fr) | 1988-06-03 | 1990-10-26 | Kodak Pathe | Repartiteur de fluide, et dispositif de traitement de fluide, tel qu'un chromatographe, equipe d'un tel repartiteur |
| GB9020306D0 (en) * | 1990-09-17 | 1990-10-31 | Dynochrom A S | Improvements in or relating to chromatography |
| DE4118501A1 (de) * | 1991-06-03 | 1992-12-10 | Saeulentechnik Dr Ing Herbert | Probenverteiler |
| US5354460A (en) | 1993-01-28 | 1994-10-11 | The Amalgamated Sugar Company | Fluid transfer system with uniform fluid distributor |
| US5423982A (en) | 1994-05-31 | 1995-06-13 | Biosepra Inc. | Liquid chromatography column adapted for in situ chemical sterilization |
| US6289914B1 (en) * | 2000-08-16 | 2001-09-18 | Novartis Ag | Microflow splitter |
-
2001
- 2001-05-11 GB GB0111486A patent/GB0111486D0/en not_active Ceased
-
2002
- 2002-05-10 EP EP02740581.0A patent/EP1393058B1/en not_active Expired - Lifetime
- 2002-05-10 AU AU2002314053A patent/AU2002314053A1/en not_active Abandoned
- 2002-05-10 CA CA 2446080 patent/CA2446080C/en not_active Expired - Fee Related
- 2002-05-10 WO PCT/EP2002/005144 patent/WO2002093159A2/en not_active Ceased
- 2002-05-10 JP JP2002589789A patent/JP4263490B2/ja not_active Expired - Lifetime
- 2002-05-10 US US10/476,903 patent/US7051758B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB0111486D0 (en) | 2001-07-04 |
| CA2446080A1 (en) | 2002-11-21 |
| WO2002093159A3 (en) | 2003-01-09 |
| EP1393058B1 (en) | 2015-03-25 |
| EP1393058A2 (en) | 2004-03-03 |
| US20040140007A1 (en) | 2004-07-22 |
| AU2002314053A1 (en) | 2002-11-25 |
| US7051758B2 (en) | 2006-05-30 |
| JP4263490B2 (ja) | 2009-05-13 |
| WO2002093159A2 (en) | 2002-11-21 |
| JP2004525384A (ja) | 2004-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140512 |