CA2432370C - Vaccin attenue a flavivirus vivant caracterise par une deletion dans la proteine capsidique - Google Patents

Vaccin attenue a flavivirus vivant caracterise par une deletion dans la proteine capsidique Download PDF

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Publication number
CA2432370C
CA2432370C CA2432370A CA2432370A CA2432370C CA 2432370 C CA2432370 C CA 2432370C CA 2432370 A CA2432370 A CA 2432370A CA 2432370 A CA2432370 A CA 2432370A CA 2432370 C CA2432370 C CA 2432370C
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gly
virus
lys
arg
flavivirus
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Expired - Fee Related
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CA2432370A
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CA2432370A1 (fr
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Franz X. Heinz
Christian Mandl
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Intercell Austria AG
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Publication of CA2432370A1 publication Critical patent/CA2432370A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un vaccin atténué à flavivirus vivant, renfermant un flavivirus mutant et caractérisé en ce que ce flavivirus mutant présente une délétion dans la protéine capsidique d'au moins plus de 4 acides aminés successifs, la région hydrophobe carboxy-terminale n'étant pas concernée par cette délétion.
CA2432370A 2001-02-21 2002-02-11 Vaccin attenue a flavivirus vivant caracterise par une deletion dans la proteine capsidique Expired - Fee Related CA2432370C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ATA272/2001 2001-02-21
AT0027201A AT410634B (de) 2001-02-21 2001-02-21 Attenuierte lebendimpfstoffe
PCT/AT2002/000046 WO2002066621A1 (fr) 2001-02-21 2002-02-11 Vaccins attenues a virus vivants

Publications (2)

Publication Number Publication Date
CA2432370A1 CA2432370A1 (fr) 2002-08-29
CA2432370C true CA2432370C (fr) 2012-01-31

Family

ID=3670551

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2432370A Expired - Fee Related CA2432370C (fr) 2001-02-21 2002-02-11 Vaccin attenue a flavivirus vivant caracterise par une deletion dans la proteine capsidique

Country Status (10)

Country Link
US (2) US8486419B2 (fr)
EP (1) EP1373478B1 (fr)
JP (2) JP5091385B2 (fr)
KR (1) KR100850620B1 (fr)
CN (3) CN101658669A (fr)
AT (2) AT410634B (fr)
AU (1) AU2002229390B2 (fr)
CA (1) CA2432370C (fr)
DE (1) DE50206472D1 (fr)
WO (1) WO2002066621A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT410634B (de) * 2001-02-21 2003-06-25 Franz X Dr Heinz Attenuierte lebendimpfstoffe
AU2003258611A1 (en) * 2002-08-13 2004-03-03 Akzo Nobel N.V. Replicons of pestiviruses that do not express c and or e1 protein and infectious viral particles containing same, that can be used in vaccines
WO2004016586A2 (fr) * 2002-08-16 2004-02-26 Board Of Regents The University Of Texas System Compositions et methodes associees aux antigenes de domaine iii de la proteine d'enveloppe du flavivirus
CN1304579C (zh) * 2003-07-21 2007-03-14 上海天甲生物医药有限公司 重组的以黄热病病毒为载体的疫苗
WO2005040390A1 (fr) * 2003-07-21 2005-05-06 Shanghai Tengen Biomedical Co., Ltd. Vaccin recombine utilisant le virus de la fievre jaune comme vecteur
CN103088038B (zh) * 2004-07-12 2015-06-24 美国天甲生物医药有限公司 黄病毒疫苗
CA2582534A1 (fr) * 2004-09-09 2006-03-16 Research Development Foundation Variants de flavivirus ayant une variation phenotypique et les compositions immunogeniques correspondantes
EP1896069B1 (fr) 2005-06-24 2013-03-13 Intervet International BV Vaccins chimères inactivés et leurs procédés d'utilisation
WO2007098267A2 (fr) 2006-02-27 2007-08-30 The Board Of Regents Of The University Of Texas System Flavivirus pseudo-infectieux et ses utilisations
FR2906724B1 (fr) 2006-10-04 2009-03-20 Sanofi Pasteur Sa Methode d'immunisation contre les 4 serotypes de la dengue.
HUE031617T2 (en) * 2007-04-06 2017-07-28 Takeda Vaccines Inc Methods and preparations for live attenuated viruses
WO2009098277A1 (fr) 2008-02-08 2009-08-13 Intercell Ag Flavivirus mutés comprenant une délétion dans la protéine capsidique utilisés comme vaccins
EP2589392B1 (fr) 2008-03-05 2016-11-30 Sanofi Pasteur Procédé de stabilisation d'une composition vaccinale contenant un adjuvant
EP2143440A1 (fr) 2008-07-09 2010-01-13 Sanofi Pasteur Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués
EP2353609A1 (fr) 2010-02-04 2011-08-10 Sanofi Pasteur Compositions et procédés d'immunisation
WO2011101465A1 (fr) 2010-02-19 2011-08-25 Intercell Ag Nanoparticules d'ic31
CN102488893B (zh) * 2011-12-28 2013-07-17 瑞普（保定）生物药业有限公司 一种用细胞系生产鸭出血性卵巢炎灭活疫苗的方法及其制品
JP2015524421A (ja) 2012-07-24 2015-08-24 サノフィ・パスツールＳａｎｏｆｉｐａｓｔｅｕｒ ワクチン組成物
SG11201500439RA (en) 2012-07-24 2015-02-27 Sanofi Pasteur Vaccine compositions for prevention against dengue virus infection
WO2014083194A1 (fr) 2012-11-30 2014-06-05 Sanofi Pasteur Procédés d'induction d'anticorps
CN103143008B (zh) * 2013-03-07 2014-04-09 齐鲁动物保健品有限公司 一种鸭坦布苏病毒活疫苗及其制备方法
EP3355916A4 (fr) * 2015-09-30 2018-08-29 Panacea Biotec Limited Vaccin vivant atténué recombinant et stable contre la dengue
BE1024160B9 (fr) 2015-12-22 2017-12-06 Glaxosmithkline Biologicals Sa Formulation immunogène
JP7313345B2 (ja) 2017-10-05 2023-07-24 サノフィ・パスツール デング熱に対するブースターワクチン接種のための組成物
CN113215117B (zh) * 2021-05-17 2022-09-06 四川农业大学 一种鸭坦布苏病毒致弱活疫苗候选株及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184024B1 (en) 1988-07-14 2001-02-06 The United States Of America As Represented By The Department Of Health And Human Services Chimeric and/or growth-restricted flaviviruses
EP1026253B2 (fr) 1989-03-21 2012-12-19 Vical Incorporated Expression de séquences polynucléotidiques exogènes chez un vertébré
MY109299A (en) * 1990-08-15 1996-12-31 Virogenetics Corp Recombinant pox virus encoding flaviviral structural proteins
ES2254055T3 (es) * 1991-09-19 2006-06-16 The United States Of America, As Represented By The Secretary, Departm. Of Health And Human Services Flavivirus quimericos y/o de crecimiento restringido.
FR2690921B1 (fr) * 1992-05-06 1995-06-30 Bio Merieux Polypeptides de synthese appartenant au virus de l'hepatite c (vhc) et utilisables notamment pour detecter ce dernier.
JP3626187B2 (ja) 1993-06-07 2005-03-02 バイカル インコーポレイテッド 遺伝子治療に適するプラスミド
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2760367B1 (fr) * 1997-03-06 1999-04-30 Pasteur Merieux Serums Vacc Composition vaccinale destinee a la prevention ou au traitement des hepatites c
AU3844101A (en) * 2000-02-16 2001-08-27 Us Health Avirulent, immunogenic flavivirus chimeras
AT410634B (de) * 2001-02-21 2003-06-25 Franz X Dr Heinz Attenuierte lebendimpfstoffe
AU2003258611A1 (en) * 2002-08-13 2004-03-03 Akzo Nobel N.V. Replicons of pestiviruses that do not express c and or e1 protein and infectious viral particles containing same, that can be used in vaccines
WO2009098277A1 (fr) 2008-02-08 2009-08-13 Intercell Ag Flavivirus mutés comprenant une délétion dans la protéine capsidique utilisés comme vaccins

Also Published As

Publication number Publication date
ATE323758T1 (de) 2006-05-15
EP1373478B1 (fr) 2006-04-19
US20040052818A1 (en) 2004-03-18
US20110165230A1 (en) 2011-07-07
AU2002229390B2 (en) 2006-03-16
JP2004520406A (ja) 2004-07-08
WO2002066621A1 (fr) 2002-08-29
EP1373478A1 (fr) 2004-01-02
CA2432370A1 (fr) 2002-08-29
CN101670101A (zh) 2010-03-17
ATA2722001A (de) 2002-11-15
KR20030081457A (ko) 2003-10-17
KR100850620B1 (ko) 2008-08-05
DE50206472D1 (de) 2006-05-24
US8784839B2 (en) 2014-07-22
US8486419B2 (en) 2013-07-16
JP5091385B2 (ja) 2012-12-05
CN1492923A (zh) 2004-04-28
CN101658669A (zh) 2010-03-03
AT410634B (de) 2003-06-25
JP2010132686A (ja) 2010-06-17

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