CA2431321C - Monoclonal antibodies to human immunodeficiency virus and uses thereof - Google Patents

Monoclonal antibodies to human immunodeficiency virus and uses thereof Download PDF

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Publication number
CA2431321C
CA2431321C CA2431321A CA2431321A CA2431321C CA 2431321 C CA2431321 C CA 2431321C CA 2431321 A CA2431321 A CA 2431321A CA 2431321 A CA2431321 A CA 2431321A CA 2431321 C CA2431321 C CA 2431321C
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CA
Canada
Prior art keywords
hiv
antibody
antigen
test sample
complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2431321A
Other languages
English (en)
French (fr)
Other versions
CA2431321A1 (en
Inventor
Sheng C. Lou
Jeffrey C. Hunt
John G. Konrath
Xiaoxing Qiu
James W. Scheffel
Joan D. Tyner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2431321A1 publication Critical patent/CA2431321A1/en
Application granted granted Critical
Publication of CA2431321C publication Critical patent/CA2431321C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1054—Lentiviridae, e.g. HIV, FIV, SIV gag-pol, e.g. p17, p24
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • C07K14/161—HIV-1 ; HIV-2 gag-pol, e.g. p55, p24/25, p17/18, p7, p6, p66/68, p51/52, p31/34, p32, p40
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2431321A 2000-12-06 2001-12-05 Monoclonal antibodies to human immunodeficiency virus and uses thereof Expired - Lifetime CA2431321C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/731,126 2000-12-06
US09/731,126 US6818392B2 (en) 2000-12-06 2000-12-06 Monoclonal antibodies to human immunodeficiency virus and uses thereof
PCT/US2001/043179 WO2002064615A2 (en) 2000-12-06 2001-12-05 Monoclonal antibodies to human immunodeficiency virus and uses thereof

Publications (2)

Publication Number Publication Date
CA2431321A1 CA2431321A1 (en) 2002-08-22
CA2431321C true CA2431321C (en) 2012-05-29

Family

ID=24938175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2431321A Expired - Lifetime CA2431321C (en) 2000-12-06 2001-12-05 Monoclonal antibodies to human immunodeficiency virus and uses thereof

Country Status (6)

Country Link
US (10) US6818392B2 (enExample)
EP (2) EP1341820A2 (enExample)
JP (1) JP4489351B2 (enExample)
CA (1) CA2431321C (enExample)
ES (1) ES2619370T3 (enExample)
WO (1) WO2002064615A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818392B2 (en) * 2000-12-06 2004-11-16 Abbott Laboratories Monoclonal antibodies to human immunodeficiency virus and uses thereof
US20040063220A1 (en) * 2002-02-27 2004-04-01 Lebrun Stewart J. Substrate chemistry for protein immobilization on a rigid support
US20050054118A1 (en) * 2002-02-27 2005-03-10 Lebrun Stewart J. High throughput screening method
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
WO2008059553A1 (en) * 2006-11-13 2008-05-22 Masami Moriyama Method for detecting hiv-1 without being affected by anti-mouse protein antibody existing in human and kit to be used for the same
FI120376B (fi) * 2007-01-17 2009-09-30 Next Biomed Technologies Nbt O Menetelmä biomuokatun, korkean affiniteetin polypeptidin valmistamiseksi
US20090181359A1 (en) 2007-10-25 2009-07-16 Lou Sheng C Method of performing ultra-sensitive immunoassays
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
CN102076355B (zh) 2008-04-29 2014-05-07 Abbvie公司 双重可变结构域免疫球蛋白及其用途
AU2009256246B2 (en) 2008-06-03 2013-07-18 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
SG191639A1 (en) 2008-06-03 2013-07-31 Abbott Lab Dual variable domain immunoglobulins and uses thereof
AU2009268585C1 (en) 2008-07-08 2014-10-02 Abbvie Inc. Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
US20110236373A1 (en) * 2008-09-25 2011-09-29 Georgia Tomaras Method of detecting antibodies and antibody-hiv virion complexes
US8916154B2 (en) * 2009-04-27 2014-12-23 Abbott Laboratories Antibodies against delta-5 desaturase and uses thereof
JP2012525441A (ja) * 2009-05-01 2012-10-22 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリンおよびこの使用
US20100297778A1 (en) * 2009-05-20 2010-11-25 Abbott Laboratories Conjugate Having Cleavable Linking Agent
DK2478364T3 (da) 2009-09-15 2017-11-13 Gemini Res Limited Påvisning af autoantistoffer mod nukleære antigener
UY32948A (es) * 2009-10-15 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
TW201206473A (en) 2010-08-03 2012-02-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
CA2809363A1 (en) * 2010-08-24 2012-03-01 Abbott Laboratories Hiv core protein specific antibodies and uses thereof
CN103260639A (zh) 2010-08-26 2013-08-21 Abbvie公司 双重可变结构域免疫球蛋白及其用途
PT2691530T (pt) 2011-06-10 2018-05-10 Univ Oregon Health & Science Glicoproteínas e vectores recombinantes cmv
US20130064811A1 (en) * 2011-09-09 2013-03-14 International Business Machines Corporation Methods to Enhance Cancer Treatment
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
WO2013102042A2 (en) 2011-12-30 2013-07-04 Abbvie Inc. Dual specific binding proteins directed against il-13 and/or il-17
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
HK1212359A1 (en) 2012-11-01 2016-06-10 Abbvie Inc. Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
JP2016522793A (ja) 2013-03-15 2016-08-04 アッヴィ・インコーポレイテッド ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (en) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
CN105929157A (zh) * 2016-05-25 2016-09-07 苏州新波生物技术有限公司 一种联合检测hiv抗原抗体的诊断试剂盒及其制备方法
WO2018133038A1 (zh) * 2017-01-20 2018-07-26 深圳市新产业生物医学工程股份有限公司 标记复合物及其制备方法、试剂盒、应用和检测系统
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
CN115812078A (zh) * 2020-07-13 2023-03-17 盖立复诊断解决方案公司 抗人类免疫缺陷病毒-1抗体及其使用方法
CN119390828A (zh) * 2024-12-31 2025-02-07 天津龙晟生物科技有限公司 人类免疫缺陷病毒hiv抗体及其应用和其检测产品

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3006207C2 (de) 1980-02-15 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Elektrische Maschine mit einem Ständerblechpaket aus kornorientierten Blechen
CA1341482C (en) * 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
DE3445816C1 (de) 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flaechenfoermiges diagnostisches Mittel
US4839288A (en) * 1986-01-22 1989-06-13 Institut Pasteur Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes
ZA873215B (en) 1986-05-19 1987-10-28 Viral Technologies Inc. Htlv-iii/lav virus related peptides,antibodies to the peptides,vaccines,passive and active immunization against aids virus and diagnostic test for the serological detection of aids virus
DE3636540A1 (de) 1986-10-27 1988-04-28 Behringwerke Ag Verfahren zur bestimmung von anti-hiv, mittel dazu und ihre verwendung in diesem verfahren
DE3705686C2 (de) * 1987-02-23 1995-11-30 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Antikörpern
US5104790A (en) 1987-06-29 1992-04-14 Genetic Systems Corporation Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use
US4886742A (en) 1987-06-15 1989-12-12 Coulter Corporation Enzyme immunoassay for detecting HIV antigens in human sera
US4888290A (en) 1987-11-06 1989-12-19 Coulter Corporation Monoclonal antibody specific to HIV antigens
DE3819079A1 (de) 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
ES2072853T3 (es) 1988-06-09 1995-08-01 Innogenetics Nv Retrovirus hiv-3 y su utilizacion.
US5173399A (en) 1988-06-10 1992-12-22 Abbott Laboratories Mouse monoclonal antibodies to hiv-1p24 and their use in diagnostic tests
CA1335880C (en) * 1988-07-14 1995-06-13 Thomas P. O'connor Detection of an antibody and antigen in an immunoassay
US5731189A (en) 1989-02-28 1998-03-24 New York University Human monoclonal antibodies to human immunodeficiency virus
ES2094124T3 (es) 1989-03-09 1997-01-16 Abbott Lab Ensayo-inmunologico de anticuerpos contra hiv.
ZA903492B (en) 1989-05-15 1991-02-27 Akzo Nv T-lymphotropic retrovirus monoclonal antibodies
US5210181A (en) * 1989-05-15 1993-05-11 Akzo N.V. T-lymphotropic retrovirus peptide
JPH0831392B2 (ja) * 1990-04-26 1996-03-27 株式会社村田製作所 積層コンデンサ
DE4039925A1 (de) 1990-12-14 1992-06-17 Behringwerke Ag Ausgewaehlte peptide des gruppenspezifischen antigens (gag) von humanem immundefizienzvirus (hiv), ihre herstellung und verwendung
EP0519866A1 (en) 1991-06-18 1992-12-23 Ciba-Geigy Ag Novel anti-HIV antibodies
JP2001504572A (ja) 1992-04-09 2001-04-03 アボツト・ラボラトリーズ Ｈｉｖ抗原及びｈｉｖ抗体を検出するためのアッセイ
DE4236189A1 (de) 1992-10-27 1994-04-28 Boehringer Mannheim Gmbh Verfahren zur simultanen Bestimmung von Antigenen und Antikörpern
EP0627625A1 (en) 1993-06-04 1994-12-07 Abbott Laboratories Immunoassay for differential diagnosis
US5611253A (en) * 1993-09-07 1997-03-18 Tohoku Ricoh Co., Ltd. Cutting device
JPH08510063A (ja) 1994-03-02 1996-10-22 アボツト・ラボラトリーズ リコンビナントタンパクおよび合成ペプチド試薬を用いるｈｉｖイムノアッセイ
ES2171190T3 (es) 1994-07-25 2002-09-01 Roche Diagnostics Gmbh Peptidos marcados con haptenos.
US6531572B1 (en) 1994-07-25 2003-03-11 Roche Diagnostics Gmbh Metal chelate-labelled peptides
CN1148578C (zh) 1994-07-25 2004-05-05 罗切诊断学有限公司 免疫测定特异抗体的方法、所用试剂、抗原及其用途
PT787191E (pt) * 1994-10-20 2007-12-06 Pasteur Institut Sequências nucleotídicas de antigénios retroviraisde vih do tipo (ou sub-tipo) o
US6015662A (en) 1996-01-23 2000-01-18 Abbott Laboratories Reagents for use as calibrators and controls
CA2283058C (en) 1997-03-10 2011-09-27 Roche Diagnostics Gmbh Procedure for simultaneous determination of hiv antigens and hiv antibodies
DE19727943A1 (de) 1997-03-10 1998-09-24 Boehringer Mannheim Gmbh Verfahren zur simultanen Bestimmung von HIV-Antigenen und HIV-Antikörpern
US6596302B2 (en) 2000-04-13 2003-07-22 Abbott Laboratories Infant formulas containing long-chain polyunsaturated fatty acids and uses thereof
US6818392B2 (en) * 2000-12-06 2004-11-16 Abbott Laboratories Monoclonal antibodies to human immunodeficiency virus and uses thereof
CA2809363A1 (en) * 2010-08-24 2012-03-01 Abbott Laboratories Hiv core protein specific antibodies and uses thereof

Also Published As

Publication number Publication date
US20050025772A1 (en) 2005-02-03
JP2004536568A (ja) 2004-12-09
US20050031624A1 (en) 2005-02-10
US7531639B2 (en) 2009-05-12
US7531640B2 (en) 2009-05-12
WO2002064615A2 (en) 2002-08-22
JP4489351B2 (ja) 2010-06-23
US20050053610A1 (en) 2005-03-10
US7528238B2 (en) 2009-05-05
US20050053925A1 (en) 2005-03-10
US20050053924A1 (en) 2005-03-10
ES2619370T3 (es) 2017-06-26
US6818392B2 (en) 2004-11-16
US20040101831A1 (en) 2004-05-27
US20120100632A1 (en) 2012-04-26
US7531642B2 (en) 2009-05-12
US9115189B2 (en) 2015-08-25
US20050058994A1 (en) 2005-03-17
EP2336175B1 (en) 2017-01-18
CA2431321A1 (en) 2002-08-22
US20130130233A1 (en) 2013-05-23
US7531638B2 (en) 2009-05-12
WO2002064615A3 (en) 2003-04-17
EP2336175A1 (en) 2011-06-22
US7531641B2 (en) 2009-05-12
US7897332B2 (en) 2011-03-01
EP1341820A2 (en) 2003-09-10
US20020106636A1 (en) 2002-08-08

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