CA2430430A1 - Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde - Google Patents

Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde Download PDF

Info

Publication number
CA2430430A1
CA2430430A1 CA002430430A CA2430430A CA2430430A1 CA 2430430 A1 CA2430430 A1 CA 2430430A1 CA 002430430 A CA002430430 A CA 002430430A CA 2430430 A CA2430430 A CA 2430430A CA 2430430 A1 CA2430430 A1 CA 2430430A1
Authority
CA
Canada
Prior art keywords
probe
target
binding
interface
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002430430A
Other languages
English (en)
Inventor
Joshua Salafsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2430430A1 publication Critical patent/CA2430430A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne une technique optique non linéaire sélective en surface, par exemple génération de la deuxième harmonique ou de la fréquence-somme, utilisée pour détecter des réactions entre des sondes fixées aux surfaces et des cibles étiquetées, ou pour réaliser l'imagerie d'une surface. Ladite technique permet de détecter uniquement les composants cibles à proximité de l'interface et d'ignorer ceux présents dans la masse de l'échantillon. En outre, l'orientation de la lumière non linéaire est diffusée de la surface dans une direction bien définie et, de ce fait, son incidence sur le détecteur à quelque distance de la surface peut être aisément mise en correspondance dans un emplacement spécifique et connu sur la surface.
CA002430430A 2000-11-29 2001-07-17 Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde Abandoned CA2430430A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US25386200P 2000-11-29 2000-11-29
US60/253,862 2000-11-29
US26024901P 2001-01-08 2001-01-08
US60/260,249 2001-01-08
US26577501P 2001-02-01 2001-02-01
US60/265,775 2001-02-01
US27864101P 2001-03-27 2001-03-27
US60/278,641 2001-03-27
PCT/US2001/022411 WO2002044412A1 (fr) 2000-11-29 2001-07-17 Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde

Publications (1)

Publication Number Publication Date
CA2430430A1 true CA2430430A1 (fr) 2002-06-06

Family

ID=27500490

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002430430A Abandoned CA2430430A1 (fr) 2000-11-29 2001-07-17 Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde

Country Status (5)

Country Link
EP (1) EP1346064A4 (fr)
AU (1) AU2001278937A1 (fr)
CA (1) CA2430430A1 (fr)
IL (1) IL156114A0 (fr)
WO (1) WO2002044412A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953694B2 (en) 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US8088628B2 (en) 2002-09-30 2012-01-03 Intel Corporation Stimulated and coherent anti-stokes raman spectroscopic methods for the detection of molecules
US20040142484A1 (en) * 2002-09-30 2004-07-22 Intel Corporation Spectroscopic analysis system and method
CN100554935C (zh) * 2002-10-07 2009-10-28 英国国防部 波导结构
JP4173746B2 (ja) * 2003-02-12 2008-10-29 富士フイルム株式会社 測定装置
JP2004279040A (ja) * 2003-03-12 2004-10-07 Toyobo Co Ltd 表面プラズモン共鳴測定用フローセル
US8008094B2 (en) 2003-12-25 2011-08-30 National Institute Of Advanced Industrial Science And Technology Methods for analyzing interactions between proteins and sugar chains
JP3918040B2 (ja) * 2004-03-03 2007-05-23 アイダエンジニアリング株式会社 マイクロチップ及びｐｄｍｓ基板と対面基板との貼り合わせ方法
EP2453240B1 (fr) 2005-05-23 2016-12-28 Harald F. Hess Microscopie optique avec marqueurs optiques phototransformables
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2010087142A1 (fr) 2009-01-27 2010-08-05 パナソニック株式会社 Détecteur de résonance plasmonique de surface, détecteur de résonance plasmonique localisé et leur procédé de fabrication
AU2012230899A1 (en) 2011-03-21 2013-10-10 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
WO2016003936A1 (fr) * 2014-06-30 2016-01-07 Biodesy, Inc. Systèmes et procédés d'analyse de conformation à haut rendement dans des entités biologiques
WO2016106286A1 (fr) 2014-12-23 2016-06-30 Biodesy, Inc. Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire
WO2017196891A1 (fr) 2016-05-09 2017-11-16 Biodesy, Inc. Méthodes et dispositifs de détection d'interactions de protéines membranaires périphériques à l'aide de techniques optiques non linéaires
US20200362397A1 (en) * 2017-05-31 2020-11-19 Centrillion Technology Holdings Corporation Oligonucleotide probe array with electronic detection system
CN110487686B (zh) * 2019-09-03 2022-09-02 中国工程物理研究院流体物理研究所 一种空气气溶胶单粒子多模态光谱诊断装置及诊断方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508559D0 (en) * 1995-04-27 1995-06-14 Polytech Transfer Ltd Surface second harmonic and sum-frequency generation immuno and enzyme assays
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5821060A (en) * 1996-08-02 1998-10-13 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA
JPH11119270A (ja) * 1997-10-17 1999-04-30 Naoya Ogata 有機非線形光学材料及びその製造方法
US6953694B2 (en) * 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

Also Published As

Publication number Publication date
WO2002044412A1 (fr) 2002-06-06
AU2001278937A1 (en) 2002-06-11
WO2002044412A8 (fr) 2003-12-11
EP1346064A1 (fr) 2003-09-24
EP1346064A4 (fr) 2005-01-19
IL156114A0 (en) 2003-12-23

Similar Documents

Publication Publication Date Title
US20020094528A1 (en) Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interations
US20020127563A1 (en) Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions without labels
US8497073B2 (en) Method using a nonlinear optical technique for detection of interactions involving a conformational change
US20050118731A1 (en) Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions without labels
CA2430430A1 (fr) Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde
EP1895289B1 (fr) Capteur à codage automatique doté de microsphères
US6210896B1 (en) Molecular motors
AU755913B2 (en) Nucleic acid biosensor diagnostics
JP2004521323A (ja) 表面選択的非線形光学技法を使用してプローブ−ターゲット相互作用を検出する方法および装置
WO2000016101A9 (fr) Detecteurs de substances ciblees a analyser mettant en application des microspheres
US20030068639A1 (en) Detecting biochemical reactions
WO2003064991A2 (fr) Procede et appareil utilisant une technique optique non lineaire pour la detection d'interactions sondes-cibles dans un champ
Hoff et al. Lipoconjugates for the noncovalent generation of microarrays in biochemical and cellular assays
Vo-Dinh Biosensors for medical applications
WO2002028530A2 (fr) Capteur d'auto-codage a microspheres
AU2001276947A1 (en) Method and apparatus using a surface-selective nonlinear optical technique
JP2005017233A (ja) 生化学反応体の検出方法とバイオチップ
Allain et al. Tuan Vo-Dinh
CA2208165A1 (fr) Diagnostics grace a un biodetecteur d'acide nucleique
CA2294603A1 (fr) Diagnostic par biocapteurs a acides nucleiques

Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20050718

FZDE Discontinued

Effective date: 20050718