IL156114A0 - Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions - Google Patents

Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions

Info

Publication number
IL156114A0
IL156114A0 IL15611401A IL15611401A IL156114A0 IL 156114 A0 IL156114 A0 IL 156114A0 IL 15611401 A IL15611401 A IL 15611401A IL 15611401 A IL15611401 A IL 15611401A IL 156114 A0 IL156114 A0 IL 156114A0
Authority
IL
Israel
Prior art keywords
probe
detection
nonlinear optical
optical technique
target interactions
Prior art date
Application number
IL15611401A
Other languages
English (en)
Original Assignee
Joshua S Salafsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joshua S Salafsky filed Critical Joshua S Salafsky
Publication of IL156114A0 publication Critical patent/IL156114A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)
IL15611401A 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions IL156114A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25386200P 2000-11-29 2000-11-29
US26024901P 2001-01-08 2001-01-08
US26577501P 2001-02-01 2001-02-01
US27864101P 2001-03-27 2001-03-27
PCT/US2001/022411 WO2002044412A1 (fr) 2000-11-29 2001-07-17 Procede et appareil utilisant une technique optique non lineaire selective en surface pour la detection d'interactions cible-sonde

Publications (1)

Publication Number Publication Date
IL156114A0 true IL156114A0 (en) 2003-12-23

Family

ID=27500490

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15611401A IL156114A0 (en) 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions

Country Status (5)

Country Link
EP (1) EP1346064A4 (fr)
AU (1) AU2001278937A1 (fr)
CA (1) CA2430430A1 (fr)
IL (1) IL156114A0 (fr)
WO (1) WO2002044412A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953694B2 (en) * 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US8088628B2 (en) 2002-09-30 2012-01-03 Intel Corporation Stimulated and coherent anti-stokes raman spectroscopic methods for the detection of molecules
US20040142484A1 (en) * 2002-09-30 2004-07-22 Intel Corporation Spectroscopic analysis system and method
CN100554935C (zh) * 2002-10-07 2009-10-28 英国国防部 波导结构
JP4173746B2 (ja) * 2003-02-12 2008-10-29 富士フイルム株式会社 測定装置
JP2004279040A (ja) * 2003-03-12 2004-10-07 Toyobo Co Ltd 表面プラズモン共鳴測定用フローセル
WO2005064333A1 (fr) 2003-12-25 2005-07-14 National Institute Of Advanced Industrial Science And Technology Procede d'analyse de l'interaction entre proteine et chaine de sucre
JP3918040B2 (ja) * 2004-03-03 2007-05-23 アイダエンジニアリング株式会社 マイクロチップ及びｐｄｍｓ基板と対面基板との貼り合わせ方法
JP4709278B2 (ja) 2005-05-23 2011-06-22 エフ． ヘスス ハラルド 光変換可能な光学標識を用いる光学顕微鏡法
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US8699032B2 (en) 2009-01-27 2014-04-15 Panasonic Corporation Surface plasmon resonance sensor, localized plasmon resonance sensor, and method for manufacturing same
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
GB2531213B (en) * 2014-06-30 2020-09-16 Biodesy Inc Systems and methods for high throughput analysis of conformation in biological entities
EP3237906B8 (fr) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Fixation de protéines à des interfaces destinées à être utilisées en détection optique non linéaire
EP3455628A4 (fr) 2016-05-09 2019-12-04 Biodesy, Inc. Méthodes et dispositifs de détection d'interactions de protéines membranaires périphériques à l'aide de techniques optiques non linéaires
US20200362397A1 (en) * 2017-05-31 2020-11-19 Centrillion Technology Holdings Corporation Oligonucleotide probe array with electronic detection system
CN110487686B (zh) * 2019-09-03 2022-09-02 中国工程物理研究院流体物理研究所 一种空气气溶胶单粒子多模态光谱诊断装置及诊断方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508559D0 (en) * 1995-04-27 1995-06-14 Polytech Transfer Ltd Surface second harmonic and sum-frequency generation immuno and enzyme assays
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5821060A (en) * 1996-08-02 1998-10-13 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA
JPH11119270A (ja) * 1997-10-17 1999-04-30 Naoya Ogata 有機非線形光学材料及びその製造方法
US6953694B2 (en) * 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

Also Published As

Publication number Publication date
EP1346064A1 (fr) 2003-09-24
AU2001278937A1 (en) 2002-06-11
WO2002044412A1 (fr) 2002-06-06
CA2430430A1 (fr) 2002-06-06
WO2002044412A8 (fr) 2003-12-11
EP1346064A4 (fr) 2005-01-19

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