CA2417736A1 - Dispersions solides de citrate de sildenafil ayant une forte solubilite dans l'eau - Google Patents
Dispersions solides de citrate de sildenafil ayant une forte solubilite dans l'eau Download PDFInfo
- Publication number
- CA2417736A1 CA2417736A1 CA002417736A CA2417736A CA2417736A1 CA 2417736 A1 CA2417736 A1 CA 2417736A1 CA 002417736 A CA002417736 A CA 002417736A CA 2417736 A CA2417736 A CA 2417736A CA 2417736 A1 CA2417736 A1 CA 2417736A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- sildenafil citrate
- water soluble
- xylitol
- highly water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cette invention se rapporte à des dispersions solides de citrate de sildénafil et à certains sucres fortement hydrosolubles, ces dispersions solides accroissant considérablement la solubilité dans l'eau du citrate de sildénafil et sa biodisponibilité. Cette invention concerne des procédés pour préparer des dispersions solides de citrate de sildénafil fortement hydrosolubles. Ces dispersions solides facilitent l'incorporation du citrate de sildénafil dans de nouvelles formes posologiques contenant du citrate de sildénafil, ce qui était jusqu'à présent impossible à mettre en pratique. Un procédé pour améliorer et/ou stimuler les réactions sexuelles chez les animaux, en particulier chez l'homme en administrant ces nouvelles formes posologiques contenant du citrate de sildénafil est également décrit.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61989900A | 2000-07-19 | 2000-07-19 | |
US09/619,899 | 2000-07-19 | ||
PCT/US2001/022538 WO2002005820A1 (fr) | 2000-07-19 | 2001-07-18 | Dispersions solides de citrate de sildenafil ayant une forte solubilite dans l'eau |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2417736A1 true CA2417736A1 (fr) | 2002-01-24 |
Family
ID=24483782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002417736A Abandoned CA2417736A1 (fr) | 2000-07-19 | 2001-07-18 | Dispersions solides de citrate de sildenafil ayant une forte solubilite dans l'eau |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1301186A1 (fr) |
AU (1) | AU2001273545A1 (fr) |
CA (1) | CA2417736A1 (fr) |
WO (1) | WO2002005820A1 (fr) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US20160175199A1 (en) * | 2002-04-11 | 2016-06-23 | Monosol Rx, Llc | Film and Drug Delivery System Made Therefrom |
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
SE0202365D0 (sv) * | 2002-08-05 | 2002-08-05 | Pharmacia Ab | New formulation and use thereof |
US20050042177A1 (en) * | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
WO2005077374A1 (fr) * | 2004-02-06 | 2005-08-25 | Becton, Dickinson And Company | Formulations d'inhibiteurs de la phosphodiesterase 5 et procedes d'utilisation |
EP1753433A1 (fr) * | 2004-05-14 | 2007-02-21 | Solvay Pharmaceuticals GmbH | Compositions pharmaceutiques renfermant des inhibiteurs de l'endopeptidase neutre (nep), des inhibiteurs du systeme de production de l'endotheline endogene et des inhibiteurs de la phosphodiesterase 5 (pde v) |
KR101232114B1 (ko) * | 2004-08-12 | 2013-02-13 | 레킷트 벵키저 헬스케어(유케이)리미티드 | 용융 압출에 의해 제조된, 파라세타몰, nsaid 및 당알콜 함유 과립 |
CA2578845A1 (fr) * | 2004-08-27 | 2006-03-23 | Spherics, Inc. | Comprimes multicouche et formes posologiques bioadhesives |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
SI2522365T1 (sl) | 2004-11-24 | 2017-02-28 | Meda Pharmaceuticals Inc. | Sestavki, ki obsegajo azelastin, in postopki njihove uporabe |
BG66010B1 (bg) * | 2004-12-08 | 2010-10-29 | "Софарма" Ад | Лекарствена форма на силденафил |
US20090142401A1 (en) * | 2005-06-07 | 2009-06-04 | Leah Elizabeth Appel | Multiparticulates comprising low-solubility drugs and carriers that result in rapid drug release |
EP1937217A2 (fr) * | 2005-09-13 | 2008-07-02 | Elan Pharma International Limited | Formulations nanoparticulaires de tadalafil |
EP2462926B1 (fr) * | 2006-05-23 | 2015-12-30 | Orahealth Corporation | Comprimé d'adhérence orale bi-couche avec adhésif de gomme d'acacia |
MY150626A (en) | 2009-10-30 | 2014-02-07 | Ix Biopharma Ltd | Fast dissolving solid dosage form |
DE102010024866A1 (de) * | 2010-06-24 | 2011-12-29 | Pharmatech Gmbh | Formulierung zur Geschmacksmaskierung |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
AU2012241189A1 (en) * | 2010-10-26 | 2014-04-24 | Ix Biopharma Pte Ltd | Fast Dissolving Solid Dosage Form |
GB2497728A (en) | 2011-12-14 | 2013-06-26 | Londonpharma Ltd | Statin formulations for transmucosal delivery |
GB2497933B (en) * | 2011-12-21 | 2014-12-24 | Londonpharma Ltd | Drug delivery technology |
US10092651B2 (en) * | 2012-02-28 | 2018-10-09 | Seoul Pharma Co., Ltd. | High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient |
EP2649989B1 (fr) * | 2012-04-13 | 2017-10-18 | King Saud University | Procédé de préparation d'une dispersion solide, dispersion solide ainsi obtenue et son utilisation |
WO2014027981A2 (fr) * | 2012-08-17 | 2014-02-20 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Formulations de comprimés effervescents de dapoxétine et d'un inhibiteur de pde5 |
US20150231092A1 (en) * | 2012-08-17 | 2015-08-20 | Sanovell IIac Sanayi Ve Ticaret Anonim Sirketi | Novel effervescent sachet formulations of dapoxetine and a pde5 inhibitor |
JP2015533155A (ja) * | 2012-10-11 | 2015-11-19 | アイエックス バイオファーマ リミテッド | 固体剤形 |
US9370518B2 (en) * | 2013-11-08 | 2016-06-21 | Insys Development Company, Inc. | Sildenafil sublingual spray formulation |
FR3013221B1 (fr) * | 2013-11-19 | 2020-11-27 | Nabil Said | Composition pharmaceutique effervescente a base de sildenafil et son procede de fabrication |
NO2723977T3 (fr) | 2014-03-19 | 2018-03-10 | ||
GB201411802D0 (en) | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
CN105435232A (zh) * | 2014-08-08 | 2016-03-30 | 深圳君圣泰生物技术有限公司 | 一种液体制剂组合物及其制备方法、用途和制剂 |
AU2015316552C1 (en) | 2014-09-17 | 2018-08-23 | Steerlife India Private Limited | Effervescent composition and method of making it |
US10111833B2 (en) | 2015-04-03 | 2018-10-30 | Insys Development Company, Inc. | Sildenafil sublingual spray formulations |
WO2016161397A1 (fr) | 2015-04-03 | 2016-10-06 | Insys Development Company, Inc. | Formulations de pulvérisation sublinguale de sildénafil |
WO2017098481A1 (fr) | 2015-12-12 | 2017-06-15 | Steerlife India Private Limited | Compositions effervescentes de metformine et leurs procédés de préparation |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
FR3052641B1 (fr) * | 2016-06-20 | 2018-06-22 | Eurotab | Utilisation de xylitol pour ameliorer la dissolution d'une tablette pour boisson froide |
CN108125916B (zh) * | 2016-12-01 | 2021-11-30 | 江苏天士力帝益药业有限公司 | 一种西地那非滴丸 |
RU2751193C2 (ru) | 2017-01-11 | 2021-07-12 | Ферринг Б.В. | Быстро распадающаяся фармацевтическая композиция |
IT201800003507A1 (it) * | 2018-03-13 | 2019-09-13 | Fulton Medicinali S P A | Compressa sublinguale comprendente sildenafil citrato |
US11179331B1 (en) | 2020-04-21 | 2021-11-23 | Cure Pharmaceutcai Holding Corp | Oral soluble film containing sildenafil citrate |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10298062A (ja) * | 1997-04-24 | 1998-11-10 | Pfizer Pharmaceut Co Ltd | 口腔内速溶型錠剤 |
AU739417B2 (en) * | 1997-05-29 | 2001-10-11 | Mochida Pharmaceutical Co., Ltd. | Therapeutic agent for erection dysfunction |
-
2001
- 2001-07-18 EP EP01952829A patent/EP1301186A1/fr not_active Withdrawn
- 2001-07-18 AU AU2001273545A patent/AU2001273545A1/en not_active Abandoned
- 2001-07-18 WO PCT/US2001/022538 patent/WO2002005820A1/fr not_active Application Discontinuation
- 2001-07-18 CA CA002417736A patent/CA2417736A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1301186A1 (fr) | 2003-04-16 |
AU2001273545A1 (en) | 2002-01-30 |
WO2002005820A1 (fr) | 2002-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |