CA2417064A1 - Composes de polyamine cyclique pour la cancerotherapie - Google Patents
Composes de polyamine cyclique pour la cancerotherapie Download PDFInfo
- Publication number
- CA2417064A1 CA2417064A1 CA002417064A CA2417064A CA2417064A1 CA 2417064 A1 CA2417064 A1 CA 2417064A1 CA 002417064 A CA002417064 A CA 002417064A CA 2417064 A CA2417064 A CA 2417064A CA 2417064 A1 CA2417064 A1 CA 2417064A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- group
- independently selected
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 **C(*)NC(**)=O Chemical compound **C(*)NC(**)=O 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22252200P | 2000-08-02 | 2000-08-02 | |
US60/222,522 | 2000-08-02 | ||
PCT/US2001/024282 WO2002010142A1 (fr) | 2000-08-02 | 2001-08-02 | Composes de polyamine cyclique pour la cancerotherapie |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2417064A1 true CA2417064A1 (fr) | 2002-02-07 |
Family
ID=22832553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002417064A Abandoned CA2417064A1 (fr) | 2000-08-02 | 2001-08-02 | Composes de polyamine cyclique pour la cancerotherapie |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1305299A1 (fr) |
JP (1) | JP2004505112A (fr) |
AU (2) | AU2001278143B2 (fr) |
CA (1) | CA2417064A1 (fr) |
IL (1) | IL153864A0 (fr) |
MX (1) | MXPA03000905A (fr) |
WO (1) | WO2002010142A1 (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10456443B2 (en) | 2014-08-27 | 2019-10-29 | Ohio State Innovation Foundation | Peptidyl calcineurin inhibitors |
US10626147B2 (en) | 2014-05-21 | 2020-04-21 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
US11168310B2 (en) | 2018-02-22 | 2021-11-09 | Entrada Therapeutics, Inc. | Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy |
US11576946B2 (en) | 2018-01-29 | 2023-02-14 | Ohio State Innovation Foundation | Peptidyl inhibitors of calcineurin-NFAT interaction |
US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026347B2 (en) | 2002-06-26 | 2006-04-11 | Cellgate, Inc. | Porphyrin-polyamine conjugates for cancer therapy |
US20070208082A1 (en) | 2005-08-10 | 2007-09-06 | John Hopkins University | Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors |
US9822364B2 (en) | 2008-03-11 | 2017-11-21 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
WO2009114614A2 (fr) | 2008-03-11 | 2009-09-17 | Yale University | Compositions et procédés pour une administration contrôlée d'acides ribonucléiques inhibiteurs |
US10465042B2 (en) | 2011-12-02 | 2019-11-05 | Yale University | Poly(amine-co-ester) nanoparticles and methods of use thereof |
WO2013082529A1 (fr) | 2011-12-02 | 2013-06-06 | Yale University | Synthèse enzymatique de poly(amine-co-esters) et ses méthodes d'utilisation pour une libération de gènes |
US9895451B2 (en) | 2011-12-02 | 2018-02-20 | Yale University | Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof |
IN2012DE00661A (fr) | 2012-03-07 | 2015-08-21 | Univ Delhi | |
WO2013173203A1 (fr) * | 2012-05-15 | 2013-11-21 | Thermo Electron Scientific Instruments Llc | Revêtement de séparateur de faisceau diélectrique multicouche à ultra large bande |
US11918695B2 (en) | 2014-05-09 | 2024-03-05 | Yale University | Topical formulation of hyperbranched polymer-coated particles |
US10238581B2 (en) | 2014-05-09 | 2019-03-26 | Yale University | Hyperbranched polyglycerol-coated particles and methods of making and using thereof |
US10682422B2 (en) | 2014-11-18 | 2020-06-16 | Yale University | Formulations for targeted release of agents under low pH conditions and methods of use thereof |
WO2016081621A1 (fr) | 2014-11-18 | 2016-05-26 | Yale University | Formulations à libération ciblée d'agents sous des conditions de ph bas, et procédés d'utilisation de celles-ci |
CA3014795A1 (fr) | 2016-02-16 | 2017-08-24 | Yale University | Compositions et procedes pour le traitement de la mucoviscidose |
US11136597B2 (en) | 2016-02-16 | 2021-10-05 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
WO2017197128A1 (fr) | 2016-05-11 | 2017-11-16 | Yale University | Nanoparticules de poly(amine-co-ester) et leurs procédés d'utilisation |
US20200113821A1 (en) | 2017-04-04 | 2020-04-16 | Yale University | Compositions and methods for in utero delivery |
WO2020033951A1 (fr) | 2018-08-10 | 2020-02-13 | Yale University | Compositions et procédés d'édition de gène embryonnaire in vitro |
US11814464B2 (en) | 2019-04-29 | 2023-11-14 | Yale University | Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof |
US20220243211A1 (en) | 2019-06-21 | 2022-08-04 | Yale University | Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof |
WO2020257779A1 (fr) | 2019-06-21 | 2020-12-24 | Yale University | Compositions pna à gamma-hydroxyméthyle modifiée et leurs procédés d'utilisation |
WO2021022161A1 (fr) | 2019-07-31 | 2021-02-04 | Yale University | Compositions et méthodes de traitement de la drépanocytose |
US20230233693A1 (en) | 2020-06-19 | 2023-07-27 | Yale University | Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery |
US20220031633A1 (en) | 2020-07-28 | 2022-02-03 | Yale University | Poly(amine-co-ester) polymeric particles for selective pulmonary delivery |
CA3240179A1 (fr) | 2021-12-08 | 2023-06-15 | Alexandra Piotrowski-Daspit | Conjugaison de surface a des nanoparticules de poly(amine-co-ester) destinees a cibler des cellules et des tissus |
WO2023159189A1 (fr) | 2022-02-18 | 2023-08-24 | Yale University | Polymères de poly(amine-co-ester) ramifiés pour une expression nucléique plus efficace |
CN117088825A (zh) * | 2023-10-12 | 2023-11-21 | 成都威斯津生物医药科技有限公司 | 一种可离子化脂质、含该可离子化脂质的药物组合物及其用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
WO1997031632A1 (fr) * | 1996-02-27 | 1997-09-04 | Eli Lilly And Company | Composes pharmaceutiques |
-
2001
- 2001-08-02 CA CA002417064A patent/CA2417064A1/fr not_active Abandoned
- 2001-08-02 EP EP01956110A patent/EP1305299A1/fr not_active Withdrawn
- 2001-08-02 AU AU2001278143A patent/AU2001278143B2/en not_active Ceased
- 2001-08-02 IL IL15386401A patent/IL153864A0/xx unknown
- 2001-08-02 AU AU7814301A patent/AU7814301A/xx active Pending
- 2001-08-02 JP JP2002516274A patent/JP2004505112A/ja not_active Withdrawn
- 2001-08-02 WO PCT/US2001/024282 patent/WO2002010142A1/fr active IP Right Grant
- 2001-08-02 MX MXPA03000905A patent/MXPA03000905A/es not_active Application Discontinuation
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10626147B2 (en) | 2014-05-21 | 2020-04-21 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
US11225506B2 (en) | 2014-05-21 | 2022-01-18 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
US10456443B2 (en) | 2014-08-27 | 2019-10-29 | Ohio State Innovation Foundation | Peptidyl calcineurin inhibitors |
US11576946B2 (en) | 2018-01-29 | 2023-02-14 | Ohio State Innovation Foundation | Peptidyl inhibitors of calcineurin-NFAT interaction |
US11168310B2 (en) | 2018-02-22 | 2021-11-09 | Entrada Therapeutics, Inc. | Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy |
US11987821B2 (en) | 2018-02-22 | 2024-05-21 | Entrada Therapeutics, Inc. | Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy |
US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
Also Published As
Publication number | Publication date |
---|---|
MXPA03000905A (es) | 2003-06-24 |
IL153864A0 (en) | 2003-07-31 |
JP2004505112A (ja) | 2004-02-19 |
AU2001278143B2 (en) | 2007-08-09 |
WO2002010142A1 (fr) | 2002-02-07 |
EP1305299A1 (fr) | 2003-05-02 |
AU7814301A (en) | 2002-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |