CA2417064A1 - Composes de polyamine cyclique pour la cancerotherapie - Google Patents

Composes de polyamine cyclique pour la cancerotherapie Download PDF

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Publication number
CA2417064A1
CA2417064A1 CA002417064A CA2417064A CA2417064A1 CA 2417064 A1 CA2417064 A1 CA 2417064A1 CA 002417064 A CA002417064 A CA 002417064A CA 2417064 A CA2417064 A CA 2417064A CA 2417064 A1 CA2417064 A1 CA 2417064A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
group
independently selected
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002417064A
Other languages
English (en)
Inventor
Benjamin Frydman
Manfred Hesse
Armin Guggisberg
Kasim Popaj
Konstantin Drandarov
Hirak Basu
Subhra Bhattacharya
Yu Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Zuerich
CellGate Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2417064A1 publication Critical patent/CA2417064A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
CA002417064A 2000-08-02 2001-08-02 Composes de polyamine cyclique pour la cancerotherapie Abandoned CA2417064A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22252200P 2000-08-02 2000-08-02
US60/222,522 2000-08-02
PCT/US2001/024282 WO2002010142A1 (fr) 2000-08-02 2001-08-02 Composes de polyamine cyclique pour la cancerotherapie

Publications (1)

Publication Number Publication Date
CA2417064A1 true CA2417064A1 (fr) 2002-02-07

Family

ID=22832553

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002417064A Abandoned CA2417064A1 (fr) 2000-08-02 2001-08-02 Composes de polyamine cyclique pour la cancerotherapie

Country Status (7)

Country Link
EP (1) EP1305299A1 (fr)
JP (1) JP2004505112A (fr)
AU (2) AU7814301A (fr)
CA (1) CA2417064A1 (fr)
IL (1) IL153864A0 (fr)
MX (1) MXPA03000905A (fr)
WO (1) WO2002010142A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10456443B2 (en) 2014-08-27 2019-10-29 Ohio State Innovation Foundation Peptidyl calcineurin inhibitors
US10626147B2 (en) 2014-05-21 2020-04-21 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US11168310B2 (en) 2018-02-22 2021-11-09 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026347B2 (en) 2002-06-26 2006-04-11 Cellgate, Inc. Porphyrin-polyamine conjugates for cancer therapy
AU2006279943B2 (en) 2005-08-10 2012-02-16 The Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
US9822364B2 (en) 2008-03-11 2017-11-21 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US9241898B2 (en) 2008-03-11 2016-01-26 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
WO2013082529A1 (fr) 2011-12-02 2013-06-06 Yale University Synthèse enzymatique de poly(amine-co-esters) et ses méthodes d'utilisation pour une libération de gènes
US9895451B2 (en) 2011-12-02 2018-02-20 Yale University Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
US10465042B2 (en) 2011-12-02 2019-11-05 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
PT2822936T (pt) 2012-03-07 2021-12-02 Univ Of Delhi Derivados da aminoquinolina e suas utilizações
DE112013002530T5 (de) * 2012-05-15 2015-02-19 Thermo Electron Scientific Instruments Llc Ultrabreitbandige mehrschichtige dielektrische Strahlteilerbeschichtung
US11918695B2 (en) 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
WO2015172149A1 (fr) 2014-05-09 2015-11-12 Yale University Particules enrobées dans un polyglycérol hyper-ramifié, leurs procédés de production et d'utilisation
WO2016081621A1 (fr) 2014-11-18 2016-05-26 Yale University Formulations à libération ciblée d'agents sous des conditions de ph bas, et procédés d'utilisation de celles-ci
US10682422B2 (en) 2014-11-18 2020-06-16 Yale University Formulations for targeted release of agents under low pH conditions and methods of use thereof
CN109476706A (zh) 2016-02-16 2019-03-15 耶鲁大学 用于促进靶向基因编辑的组合物及其使用方法
WO2017143061A1 (fr) 2016-02-16 2017-08-24 Yale University Compositions et procédés pour le traitement de la mucoviscidose
WO2017197128A1 (fr) 2016-05-11 2017-11-16 Yale University Nanoparticules de poly(amine-co-ester) et leurs procédés d'utilisation
WO2018187493A1 (fr) 2017-04-04 2018-10-11 Yale University Compositions et procédés d'administration in utero
US20210189431A1 (en) 2018-08-10 2021-06-24 Yale University Compositions and methods for embryonic gene editing in vitro
US11814464B2 (en) 2019-04-29 2023-11-14 Yale University Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
WO2020257779A1 (fr) 2019-06-21 2020-12-24 Yale University Compositions pna à gamma-hydroxyméthyle modifiée et leurs procédés d'utilisation
US20220243211A1 (en) 2019-06-21 2022-08-04 Yale University Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof
WO2021022161A1 (fr) 2019-07-31 2021-02-04 Yale University Compositions et méthodes de traitement de la drépanocytose
CA3183351A1 (fr) 2020-06-19 2021-12-23 Yale University Polymeres de poly(amine-co-ester) presentant des groupes terminaux modifies et administration pulmonaire amelioree
US20220031633A1 (en) 2020-07-28 2022-02-03 Yale University Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
WO2023108076A1 (fr) 2021-12-08 2023-06-15 Yale University Conjugaison de surface à des nanoparticules de poly(amine-co-ester) destinées à cibler des cellules et des tissus
WO2023159189A1 (fr) 2022-02-18 2023-08-24 Yale University Polymères de poly(amine-co-ester) ramifiés pour une expression nucléique plus efficace
CN117088825A (zh) * 2023-10-12 2023-11-21 成都威斯津生物医药科技有限公司 一种可离子化脂质、含该可离子化脂质的药物组合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999349A (en) * 1990-03-22 1991-03-12 Bristol-Myers Squibb Co. BU-4164E - A and B, prolyl endopeptidase inhibitors
WO1997031632A1 (fr) * 1996-02-27 1997-09-04 Eli Lilly And Company Composes pharmaceutiques

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10626147B2 (en) 2014-05-21 2020-04-21 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US11225506B2 (en) 2014-05-21 2022-01-18 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10456443B2 (en) 2014-08-27 2019-10-29 Ohio State Innovation Foundation Peptidyl calcineurin inhibitors
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
US11168310B2 (en) 2018-02-22 2021-11-09 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy

Also Published As

Publication number Publication date
IL153864A0 (en) 2003-07-31
AU7814301A (en) 2002-02-13
AU2001278143B2 (en) 2007-08-09
WO2002010142A1 (fr) 2002-02-07
JP2004505112A (ja) 2004-02-19
MXPA03000905A (es) 2003-06-24
EP1305299A1 (fr) 2003-05-02

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued