CA2416487A1 - Stimulation of bone growth with thrombin peptide derivatives - Google Patents

Stimulation of bone growth with thrombin peptide derivatives Download PDF

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Publication number
CA2416487A1
CA2416487A1 CA002416487A CA2416487A CA2416487A1 CA 2416487 A1 CA2416487 A1 CA 2416487A1 CA 002416487 A CA002416487 A CA 002416487A CA 2416487 A CA2416487 A CA 2416487A CA 2416487 A1 CA2416487 A1 CA 2416487A1
Authority
CA
Canada
Prior art keywords
gly
asp
seq
glu
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002416487A
Other languages
English (en)
French (fr)
Inventor
Darrell H. Carney
Roger S. Crowther
David J. Simmons
Jinping Yang
William R. Redin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2416487A1 publication Critical patent/CA2416487A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002416487A 2000-07-19 2001-07-18 Stimulation of bone growth with thrombin peptide derivatives Abandoned CA2416487A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21930000P 2000-07-19 2000-07-19
US60/219,300 2000-07-19
PCT/US2001/022641 WO2002005836A2 (en) 2000-07-19 2001-07-18 Stimulation of bone growth with thrombin peptide derivatives

Publications (1)

Publication Number Publication Date
CA2416487A1 true CA2416487A1 (en) 2002-01-24

Family

ID=22818711

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002416487A Abandoned CA2416487A1 (en) 2000-07-19 2001-07-18 Stimulation of bone growth with thrombin peptide derivatives

Country Status (13)

Country Link
US (3) US6914050B2 (https=)
EP (1) EP1301196B1 (https=)
JP (2) JP3691484B2 (https=)
CN (1) CN100350971C (https=)
AT (1) ATE254925T1 (https=)
AU (2) AU2001276977B2 (https=)
CA (1) CA2416487A1 (https=)
DE (1) DE60101339T2 (https=)
DK (1) DK1301196T3 (https=)
ES (1) ES2213707T3 (https=)
PT (1) PT1301196E (https=)
TR (1) TR200400260T4 (https=)
WO (1) WO2002005836A2 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895766A (en) 1995-09-20 1999-04-20 Micron Technology, Inc. Method of forming a field effect transistor
MXPA00011272A (es) 1998-05-18 2003-04-22 Univ London Una novedosa fosfatonina de hormona polipeptida.
DK1301196T3 (da) 2000-07-19 2004-03-29 Univ Texas Stimulering af knoglevækst med peptidderivater af thrombin
WO2003061690A1 (en) * 2002-01-17 2003-07-31 The Board Of Regents, The University Of Texas System Stimulation of bone growth and cartilage formation with thrombing peptide derivatives
US6911425B2 (en) * 2000-08-16 2005-06-28 Acologix, Inc. Integrin binding motif containing peptides and methods of treating skeletal diseases
ATE401350T1 (de) * 2000-08-16 2008-08-15 Acologix Inc Dentalzubereitungen enthaltend peptide, die das knochenwachstum fördern
AU2003247848B2 (en) * 2002-07-02 2006-12-21 The Board Of Regents, The University Of Texas System Thrombin peptide derivative dimers
EP1539214A4 (en) * 2002-07-02 2008-01-02 Orthologic Corp Thrombin
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
JP4740532B2 (ja) * 2003-09-30 2011-08-03 雪印乳業株式会社 骨形成促進及び骨吸収抑制剤
US20060286084A1 (en) * 2003-09-30 2006-12-21 Yoshikazu Morita Agent for promoting osteogenesis and/or inhibiting bone resorption
WO2005041998A1 (en) 2003-10-02 2005-05-12 Ali Sadat M Peptide for promoting healing of fractures
PL1559431T3 (pl) 2003-12-31 2007-10-31 Orthologic Corp Kompozycja farmaceutyczna dla pochodnych peptydu trombiny
US7622438B1 (en) 2005-07-18 2009-11-24 Acologix, Inc. Protein formulation for promoting hard tissue formation
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
ES2542509T3 (es) 2007-01-22 2015-08-06 Orthotrophix, Inc. Una composición peptídica y un método de estimulación de la formación de cartílago
WO2008100567A2 (en) * 2007-02-15 2008-08-21 Orthologic Corp. Thrombin peptide derivatives for treating fractures in osteopenic patients
CA2722620A1 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Method of treating peripheral arterial disease
JP2011515471A (ja) * 2008-03-26 2011-05-19 オーソロジック コーポレイション 急性心筋梗塞を処置するための方法
AU2009229395A1 (en) * 2008-03-26 2009-10-01 The Board Of Regents, The University Of Texas System Method of treating degenerative diseases
AU2009229399A1 (en) * 2008-03-26 2009-10-01 Orthologic Corp. Thrombin derived peptides for smooth muscle relaxation
WO2010033862A2 (en) * 2008-09-19 2010-03-25 The Board Of Regents, The University Of Texas System Methods for treating cancer
CN102250253A (zh) * 2010-05-17 2011-11-23 中国人民解放军军事医学科学院军事兽医研究所 一种含凝血酶片段融合肽
RU2551119C1 (ru) * 2013-11-29 2015-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" Времяпролетный спектрометр ионов
US10220078B2 (en) 2014-06-11 2019-03-05 The Board Of Regents Of The University Of Texas System Methods of using thrombin derivatives to treat medulloblastoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
JPH04279520A (ja) 1990-05-31 1992-10-05 Eisai Co Ltd 骨内部埋め込み用製剤
US5563124A (en) 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
JPH1033657A (ja) 1996-07-23 1998-02-10 Dainippon Ink & Chem Inc 生体内分解性材料及びその製造方法
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
EP0896825B1 (en) 1997-08-14 2002-07-17 Sulzer Innotec Ag Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
DK1301196T3 (da) * 2000-07-19 2004-03-29 Univ Texas Stimulering af knoglevækst med peptidderivater af thrombin
EP1259598B1 (en) 2000-07-20 2004-09-22 The Board of Regents, The University of Texas System Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor

Also Published As

Publication number Publication date
WO2002005836A3 (en) 2002-12-19
DE60101339T2 (de) 2004-09-09
US7304035B2 (en) 2007-12-04
JP3691484B2 (ja) 2005-09-07
DE60101339D1 (de) 2004-01-08
JP2004503596A (ja) 2004-02-05
ES2213707T3 (es) 2004-09-01
ATE254925T1 (de) 2003-12-15
US20020128202A1 (en) 2002-09-12
US6914050B2 (en) 2005-07-05
AU2001276977B2 (en) 2005-05-19
US6894027B2 (en) 2005-05-17
AU7697701A (en) 2002-01-30
HK1055250A1 (en) 2004-01-02
CN1635899A (zh) 2005-07-06
EP1301196A2 (en) 2003-04-16
CN100350971C (zh) 2007-11-28
EP1301196B1 (en) 2003-11-26
WO2002005836A2 (en) 2002-01-24
DK1301196T3 (da) 2004-03-29
JP2005053894A (ja) 2005-03-03
PT1301196E (pt) 2004-04-30
US20020182205A1 (en) 2002-12-05
TR200400260T4 (tr) 2004-03-22
US20050227923A1 (en) 2005-10-13

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JPH07500038A (ja) 骨形成性蛋白の送達のための血餅−ポリマー・マトリックスの処方
JP2001508689A (ja) 凍結乾燥コラーゲンベースの生体材料、それらの調製プロセスおよび使用
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AU2001273561A1 (en) Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued