CA2416137C - Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis - Google Patents
Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis Download PDFInfo
- Publication number
- CA2416137C CA2416137C CA2416137A CA2416137A CA2416137C CA 2416137 C CA2416137 C CA 2416137C CA 2416137 A CA2416137 A CA 2416137A CA 2416137 A CA2416137 A CA 2416137A CA 2416137 C CA2416137 C CA 2416137C
- Authority
- CA
- Canada
- Prior art keywords
- preparation
- preparations
- neisseria meningitidis
- strain
- strains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22149500P | 2000-07-27 | 2000-07-27 | |
| US60/221,495 | 2000-07-27 | ||
| PCT/US2001/023842 WO2002009643A2 (en) | 2000-07-27 | 2001-07-27 | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2416137A1 CA2416137A1 (en) | 2002-02-07 |
| CA2416137C true CA2416137C (en) | 2013-01-29 |
Family
ID=22828056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2416137A Expired - Lifetime CA2416137C (en) | 2000-07-27 | 2001-07-27 | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6936261B2 (enExample) |
| EP (1) | EP1322328B1 (enExample) |
| JP (1) | JP5511117B2 (enExample) |
| KR (1) | KR20030024811A (enExample) |
| AU (1) | AU2001280883A1 (enExample) |
| BR (1) | BRPI0112928B1 (enExample) |
| CA (1) | CA2416137C (enExample) |
| CR (1) | CR6880A (enExample) |
| EC (1) | ECSP034447A (enExample) |
| ES (1) | ES2519440T3 (enExample) |
| MX (1) | MXPA03000822A (enExample) |
| WO (1) | WO2002009643A2 (enExample) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ES2278446T3 (es) | 1998-05-29 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Vacunas combinadas b/c contra la meningitis. |
| US10967045B2 (en) | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
| GB9823978D0 (en) * | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| EP1179072A2 (en) | 1999-05-19 | 2002-02-13 | Chiron S.P.A. | Combination neisserial compositions |
| PT2275551E (pt) | 1999-10-29 | 2015-06-29 | Novartis Vaccines & Diagnostic | Péptidos antigénicos de neisseria |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| WO2001051500A1 (en) | 2000-01-14 | 2001-07-19 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| NO20002828D0 (no) * | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| MXPA03000822A (es) * | 2000-07-27 | 2004-11-01 | Childrens Hosp & Res Ct Oak | Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis. |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| US7354909B2 (en) * | 2001-08-14 | 2008-04-08 | The United States Of America As Represented By Secretary Of The Department Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| AU2002366710A1 (en) | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| AU2003239666A1 (en) * | 2002-05-14 | 2003-11-11 | Affitech As | Antibody screening libraries |
| GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| CN1674933B (zh) * | 2002-08-02 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
| RU2364418C2 (ru) * | 2002-08-02 | 2009-08-20 | ГлаксоСмитКлайн Байолоджикалз с.а. | ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB- |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| AU2003288558A1 (en) * | 2002-12-16 | 2004-07-09 | Nasjonalt Folkehelseinstitutt | Meningococcal vaccine based on outer membrane proteins porb2 and pora |
| DK1587537T3 (da) | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| US20080044440A1 (en) * | 2004-02-18 | 2008-02-21 | Margaret Dunkley | Vaccine Formulated For Administration To Mucosa Of The Lungs |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| GB0419627D0 (en) * | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| GB0424092D0 (en) * | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| CN101107007B (zh) | 2005-01-27 | 2011-08-17 | 奥克兰儿童医院及研究中心 | 对脑膜炎奈瑟球菌所致疾病具有广谱保护作用的gna1870囊泡疫苗 |
| HUE045482T2 (hu) | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| WO2007014179A2 (en) * | 2005-07-25 | 2007-02-01 | University Of Rochester | Method for controlling immunodominance |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| US8414899B2 (en) * | 2006-04-11 | 2013-04-09 | Yeda Research And Development Co. Ltd. | Vaccines comprising multimeric HSP60 peptide carriers |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| WO2009006591A1 (en) * | 2007-07-03 | 2009-01-08 | Children's Hospital & Research Center At Oakland | Inhibitors of polysialic acid de-n-acetylase and methods for using the same |
| CA2692417C (en) | 2007-07-03 | 2017-03-21 | Children's Hospital & Research Center At Oakland | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting |
| CA2690440A1 (en) | 2007-07-03 | 2009-01-08 | Children's Hospital & Research Center At Oakland | Oligosialic acid derivatives, methods of manufacture, and immunological uses |
| WO2009038889A1 (en) * | 2007-08-02 | 2009-03-26 | Children's Hospital And Research Center At Oakland | Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
| HRP20120433T1 (en) | 2007-10-19 | 2012-07-31 | Novartis@Ag | Meningococcal vaccine formulations |
| AU2009215364B2 (en) | 2008-02-21 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Meningococcal fHBP polypeptides |
| EP2294085A1 (en) * | 2008-06-09 | 2011-03-16 | Novartis AG | Antibodies against neisserial factor h binding protein |
| US9150621B2 (en) * | 2008-08-28 | 2015-10-06 | The University Of Queensland | Mutant bacterial glycoproteins and uses thereof |
| WO2010028096A2 (en) | 2008-09-03 | 2010-03-11 | Children's Hospital & Research Center At Oakland | Peptides presenting an epitope of an a domain of factor h binding protein and methods of use |
| GB0816284D0 (en) * | 2008-09-05 | 2008-10-15 | Nat Biolog Standards Board | Vaccine |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
| AU2010288239B2 (en) | 2009-08-27 | 2014-01-16 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| WO2011024072A2 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| US9950062B2 (en) | 2009-09-02 | 2018-04-24 | Glaxosmithkline Biologicals Sa | Compounds and compositions as TLR activity modulators |
| JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
| GB0917003D0 (en) | 2009-09-28 | 2009-11-11 | Novartis Vaccines Inst For Global Health Srl | Purification of bacterial vesicles |
| CN102724988B (zh) | 2009-09-30 | 2014-09-10 | 诺华股份有限公司 | 脑膜炎球菌fHBP多肽的表达 |
| CA2779816A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| JP5814933B2 (ja) | 2009-12-15 | 2015-11-17 | ノバルティス アーゲー | 免疫増強化合物の均質な懸濁物およびその使用 |
| WO2012020326A1 (en) | 2010-03-18 | 2012-02-16 | Novartis Ag | Adjuvanted vaccines for serogroup b meningococcus |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
| CA2810971C (en) | 2010-09-10 | 2020-11-03 | Novartis Ag | Developments in meningococcal outer membrane vesicles |
| US20150147356A1 (en) | 2011-05-12 | 2015-05-28 | Alan Kimura | Antipyretics to enhance tolerability of vesicle-based vaccines |
| MX2014008988A (es) | 2012-02-02 | 2014-08-27 | Novartis Ag | Promotores para aumento de expresion de proteinas en meningococo. |
| WO2013132040A2 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | In vitro potency assay for protein-based meningococcal vaccines |
| ES2847923T3 (es) | 2012-06-14 | 2021-08-04 | Glaxosmithkline Biologicals Sa | Vacunas contra el meningococo del serogrupo X |
| BR112015005056A2 (pt) | 2012-09-06 | 2017-11-21 | Novartis Ag | vacinas de combinação com sorogrupo b meningococcus e d/t/p |
| AU2013320313B2 (en) | 2012-09-18 | 2018-07-12 | Glaxosmithkline Biologicals Sa | Outer membrane vesicles |
| BR112015018877A2 (pt) | 2013-02-07 | 2017-08-22 | Externautics Spa | Método para preparar uma composição farmacêutica, e, composição farmacêutica imunogênica |
| CN106661092B (zh) | 2014-02-28 | 2021-07-06 | 葛兰素史密丝克莱恩生物有限公司 | 修饰的脑膜炎球菌fHbp多肽 |
| JP7104027B2 (ja) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 淋菌に対するワクチン |
| AU2018330322A1 (en) | 2017-09-08 | 2020-03-19 | Evelo Biosciences, Inc. | Bacterial extracellular vesicles |
| EP3607967A1 (en) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
| GB202311230D0 (en) | 2023-07-21 | 2023-09-06 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| CN121569027A (zh) | 2023-07-21 | 2026-02-24 | 葛兰素史克生物有限公司 | 免疫原性组合物 |
| TW202602458A (zh) * | 2024-02-16 | 2026-01-16 | 美商賽諾菲巴斯德公司 | 用於製備去氧膽酸之方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4601903A (en) * | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
| US4727136A (en) | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| JPH01125328A (ja) | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
| AU640118B2 (en) * | 1988-12-19 | 1993-08-19 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur | Meningococcal class 1 outer-membrane protein vaccine |
| NL9201716A (nl) | 1992-10-02 | 1994-05-02 | Nederlanden Staat | Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat. |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
| GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
| BR9813930A (pt) | 1997-11-06 | 2006-12-19 | Chiron Spa | antìgeno neisserial |
| ATE446368T1 (de) | 1998-01-14 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antigene aus neisseria meningitidis |
| MX343752B (es) | 1998-05-01 | 2016-11-22 | Novartis Vaccines & Diagnostics Inc | Antigenos de neisseria meningitidis y composiciones que los contienen. |
| ES2278446T3 (es) | 1998-05-29 | 2007-08-01 | Novartis Vaccines And Diagnostics, Inc. | Vacunas combinadas b/c contra la meningitis. |
| BR9914374A (pt) | 1998-10-09 | 2002-09-17 | Chiron Corp | Sequências genÈmicas de neisseria e métodos para seu uso |
| US20030215469A1 (en) * | 1998-11-02 | 2003-11-20 | Microbiological Research Authority | Multicomponent meningococcal vaccine |
| GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
| PT1127137E (pt) | 1998-11-03 | 2007-12-28 | Staat Nl Verteg Door Min Welzi | Lps com toxicidade reduzida a partir de bactérias gramnegativas modificadas geneticamente |
| US7081244B2 (en) * | 1999-02-22 | 2006-07-25 | Health Protection Agency | Neisserial vaccine compositions and methods |
| ES2323845T3 (es) | 1999-04-30 | 2009-07-27 | Novartis Vaccines And Diagnostics, Inc. | Secuencias genomicas de neisseria y procedimientos de uso. |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| WO2001034642A2 (en) | 1999-11-12 | 2001-05-17 | University Of Iowa Research Foundation | Control of neisserial membrane synthesis |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| ES2588917T3 (es) | 2000-01-17 | 2016-11-07 | Glaxosmithkline Biologicals Sa | Vacuna de VME suplementada contra meningococo |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| MXPA03000822A (es) * | 2000-07-27 | 2004-11-01 | Childrens Hosp & Res Ct Oak | Vacunas para proteccion de espectro amplio contra enfermedades causadas por neisseria meningitidis. |
| GB0103170D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0024200D0 (en) | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
| GB0103169D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
| ES2615362T3 (es) | 2001-07-27 | 2017-06-06 | Glaxosmithkline Biologicals Sa | Adhesinas de meningococos |
| GB0130123D0 (en) | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| EP1374892A1 (en) | 2002-06-28 | 2004-01-02 | Braun, Jan Matthias, Dr. | Medicament for the treatment of diseases due to infection by Neisseria Meningitidis |
| CN1674933B (zh) | 2002-08-02 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
| GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| EP2351579B1 (en) * | 2002-10-11 | 2016-09-21 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| CN101107007B (zh) * | 2005-01-27 | 2011-08-17 | 奥克兰儿童医院及研究中心 | 对脑膜炎奈瑟球菌所致疾病具有广谱保护作用的gna1870囊泡疫苗 |
| WO2009038889A1 (en) * | 2007-08-02 | 2009-03-26 | Children's Hospital And Research Center At Oakland | Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
-
2001
- 2001-07-27 MX MXPA03000822A patent/MXPA03000822A/es active IP Right Grant
- 2001-07-27 EP EP01959315.1A patent/EP1322328B1/en not_active Expired - Lifetime
- 2001-07-27 AU AU2001280883A patent/AU2001280883A1/en not_active Abandoned
- 2001-07-27 KR KR10-2003-7001130A patent/KR20030024811A/ko not_active Ceased
- 2001-07-27 ES ES01959315.1T patent/ES2519440T3/es not_active Expired - Lifetime
- 2001-07-27 CA CA2416137A patent/CA2416137C/en not_active Expired - Lifetime
- 2001-07-27 WO PCT/US2001/023842 patent/WO2002009643A2/en not_active Ceased
- 2001-07-27 BR BRPI0112928-7A patent/BRPI0112928B1/pt not_active IP Right Cessation
- 2001-07-27 JP JP2002515198A patent/JP5511117B2/ja not_active Expired - Lifetime
- 2001-07-27 US US09/917,222 patent/US6936261B2/en not_active Expired - Lifetime
-
2003
- 2003-01-14 CR CR6880A patent/CR6880A/es unknown
- 2003-01-24 EC EC2003004447A patent/ECSP034447A/es unknown
-
2005
- 2005-03-15 US US11/081,882 patent/US8980285B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0112928B8 (enExample) | 2021-05-25 |
| EP1322328B1 (en) | 2014-08-20 |
| MXPA03000822A (es) | 2004-11-01 |
| WO2002009643A2 (en) | 2002-02-07 |
| JP2004512269A (ja) | 2004-04-22 |
| ECSP034447A (es) | 2003-04-25 |
| US8980285B2 (en) | 2015-03-17 |
| KR20030024811A (ko) | 2003-03-26 |
| AU2001280883A1 (en) | 2002-02-13 |
| US20020110569A1 (en) | 2002-08-15 |
| CA2416137A1 (en) | 2002-02-07 |
| EP1322328A4 (en) | 2005-07-20 |
| WO2002009643A3 (en) | 2002-05-30 |
| ES2519440T3 (es) | 2014-11-07 |
| BRPI0112928B1 (pt) | 2017-08-29 |
| US6936261B2 (en) | 2005-08-30 |
| JP5511117B2 (ja) | 2014-06-04 |
| US20060029621A1 (en) | 2006-02-09 |
| CR6880A (es) | 2006-08-09 |
| BR0112928A (pt) | 2003-08-26 |
| EP1322328A2 (en) | 2003-07-02 |
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