CA2415688A1 - Traitement enzymatique des proteines de lactoserum permettant d'obtenir des peptides anti-hypertension, produits obtenus et traitement de l'hypertension chez les mammiferes - Google Patents

Traitement enzymatique des proteines de lactoserum permettant d'obtenir des peptides anti-hypertension, produits obtenus et traitement de l'hypertension chez les mammiferes Download PDF

Info

Publication number
CA2415688A1
CA2415688A1 CA002415688A CA2415688A CA2415688A1 CA 2415688 A1 CA2415688 A1 CA 2415688A1 CA 002415688 A CA002415688 A CA 002415688A CA 2415688 A CA2415688 A CA 2415688A CA 2415688 A1 CA2415688 A1 CA 2415688A1
Authority
CA
Canada
Prior art keywords
whey protein
hydrolysate
process according
protein fraction
max
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002415688A
Other languages
English (en)
Inventor
Anand Rao
Martin E. Davis
Ann Francoise Allain
Sylvie Gauthier
Line Gourley
Yves Pouliot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Davisco Foods International Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/567,283 external-priority patent/US6630320B1/en
Priority claimed from US09/702,068 external-priority patent/US6998259B1/en
Application filed by Individual filed Critical Individual
Publication of CA2415688A1 publication Critical patent/CA2415688A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des agents de digestion enzymatiques de concentrats de protéines de lactosérum préparés à l'aide de protéases animales, bactériennes et fongiques, et évalués en fonction d'activités anti-hypertension. On obtient une activité inhibant l'enzyme de conversion de l'angiotensine et une activité anti-hypertension avec un hydrolysat d'isolat de protéine de lactosérum préparé avec une trypsine porcine.
CA002415688A 2000-05-08 2001-05-08 Traitement enzymatique des proteines de lactoserum permettant d'obtenir des peptides anti-hypertension, produits obtenus et traitement de l'hypertension chez les mammiferes Abandoned CA2415688A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/567,283 2000-05-08
US09/567,283 US6630320B1 (en) 2000-05-08 2000-05-08 Treatment of hypertension in mammals with hydrolyzed whey proteins
US09/702,068 2000-10-30
US09/702,068 US6998259B1 (en) 1999-05-20 2000-10-30 Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
PCT/US2001/014797 WO2001085984A1 (fr) 2000-05-08 2001-05-08 Traitement enzymatique des proteines de lactoserum permettant d'obtenir des peptides anti-hypertension, produits obtenus et traitement de l'hypertension chez les mammiferes

Publications (1)

Publication Number Publication Date
CA2415688A1 true CA2415688A1 (fr) 2001-11-15

Family

ID=27074429

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002415688A Abandoned CA2415688A1 (fr) 2000-05-08 2001-05-08 Traitement enzymatique des proteines de lactoserum permettant d'obtenir des peptides anti-hypertension, produits obtenus et traitement de l'hypertension chez les mammiferes

Country Status (7)

Country Link
EP (1) EP1287159A4 (fr)
JP (1) JP2004519204A (fr)
AU (1) AU2001259625A1 (fr)
CA (1) CA2415688A1 (fr)
MX (1) MXPA02011018A (fr)
NZ (1) NZ523036A (fr)
WO (1) WO2001085984A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU761477B2 (en) 1998-06-17 2003-06-05 New Zealand Dairy Board Bioactive whey protein hydrolysate
DE60310934T2 (de) 2002-07-01 2007-10-11 Unilever N.V. Zusammensetzung, die ein sättigungsgefühl hervorruft
EP1466529A1 (fr) 2003-04-07 2004-10-13 Chr. Hansen A/S Composition destinée à reduire la fréquence cardiaque
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
CN1784146A (zh) * 2003-05-05 2006-06-07 荷兰联合利华有限公司 具有血管紧张素转化酶抑制作用的肽
ES2253036B1 (es) 2003-07-31 2007-07-16 Consejo Sup. Investig. Cientificas Peptidos bioactivos derivados de proteinas de la clara de huevo mediante hidrolisis enzimatica.
JP2007513900A (ja) * 2003-12-15 2007-05-31 ユニリーバー・ナームローゼ・ベンノートシヤープ Ａｃｅ阻害効果を有するペプチド
EP1685764A1 (fr) 2005-01-27 2006-08-02 Globus Egg Sciences B.V. Produits fonctionnels alimentaires hypotenseurs
NL1026931C2 (nl) * 2004-08-31 2006-03-01 Friesland Brands Bv ACE-remmende wei-hydrolysaten.
BRPI0514903A (pt) 2004-09-03 2008-06-24 Hansens Lab proteìnas vegetais ou leite fermentado compreendendo ligando de receptor e uso dos mesmos
FR2876389B1 (fr) * 2004-10-13 2007-05-25 Viridis Sa Hydrolysats de proteines blanches de luzerne
ES2319475B1 (es) 2005-06-08 2010-02-16 Consejo Superior Investig. Cientificas Peptidos bioactivos identificados en hidrolizados enzimaticos de caseinas lacteas y procedimiento de obtencion.
DE102008032828A1 (de) 2008-07-02 2010-01-07 Technische Universität Dresden Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel
PL2988780T3 (pl) 2013-04-25 2019-06-28 Janssen Vaccines & Prevention B.V. Stabilizowane rozpuszczalne prefuzyjne polipeptydy F RSV
CN107847580B (zh) 2015-07-07 2022-08-12 扬森疫苗与预防公司 针对rsv的疫苗
CA2991540A1 (fr) 2015-07-07 2017-01-12 Janssen Vaccines & Prevention B.V. Polypeptides du virus respiratoire syncytial pre-fusion solubles stabilises
WO2017174568A1 (fr) 2016-04-05 2017-10-12 Janssen Vaccines & Prevention B.V. Protéines f du vrs de pré-fusion solubles stabilisées
MX2018012095A (es) 2016-04-05 2019-01-10 Janssen Vaccines & Prevention Bv Vacuna contra vrs.
CN109311946A (zh) 2016-05-30 2019-02-05 扬森疫苗与预防公司 稳定化的融合前rsv f蛋白
AU2018267971A1 (en) 2017-05-17 2019-11-07 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against RSV infection
WO2018210871A1 (fr) 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Procédés et compositions pour induire une immunité protectrice contre l'infection par le vrs
CA3073790A1 (fr) 2017-09-15 2019-03-21 Janssen Vaccines & Prevention B.V. Procede d'induction sure de l'immunite contre le vrs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3091772B2 (ja) * 1991-03-12 2000-09-25 カルピス株式会社 アンジオテンシン変換酵素阻害ペプチド組成物
JP3149199B2 (ja) * 1991-03-12 2001-03-26 カルピス株式会社 アンジオテンシン変換酵素阻害ペプチド
CA2150571C (fr) * 1992-11-30 1998-09-29 Seiichi Shimamura Proteine de lactoserum a faible teneur en phosphore, sa methode de fabrication, hydrolisat purifie de lactoserum a faible teneur en phosphore et sa methode de fabrication
JPH06345664A (ja) * 1993-06-11 1994-12-20 Takako Tomita 新規な血圧上昇抑制用組成物
JPH1033115A (ja) * 1996-07-24 1998-02-10 Nouchikusangiyou Shinko Jigyodan ホエー飲料とその製造法
US5854029A (en) * 1996-08-02 1998-12-29 Calpis Co., Ltd. Method for preparing antihypertensive agent

Also Published As

Publication number Publication date
JP2004519204A (ja) 2004-07-02
AU2001259625A1 (en) 2001-11-20
NZ523036A (en) 2004-04-30
MXPA02011018A (es) 2004-08-19
EP1287159A4 (fr) 2005-02-09
EP1287159A1 (fr) 2003-03-05
WO2001085984A1 (fr) 2001-11-15

Similar Documents

Publication Publication Date Title
CA2415688A1 (fr) Traitement enzymatique des proteines de lactoserum permettant d'obtenir des peptides anti-hypertension, produits obtenus et traitement de l'hypertension chez les mammiferes
Liu et al. Bioactive peptides derived from egg proteins: A review
FitzGerald et al. Lactokinins: Whey protein‐derived ACE inhibitory peptides
KR101343904B1 (ko) 우유 카제인의 효소 가수분해물에서 식별된 생물활성펩티드 및 그것을 얻는 방법
Pihlanto-Leppälä Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides
Saito Antihypertensive peptides derived from bovine casein and whey proteins
EP1907412B1 (fr) Peptides ayant une activité inhibante de ace
US8227207B2 (en) Bioactive peptides derived from the proteins of egg white by means of enzymatic hydrolysis
Sato et al. Antihypertensive effects of hydrolysates of wakame (Undaria pinnatifida) and their angiotensin-I-converting enzyme inhibitory activity
US6630320B1 (en) Treatment of hypertension in mammals with hydrolyzed whey proteins
EP1794189B1 (fr) Hydrolysats du lactoserum inhibiteurs de l'enzyme de conversion de l'angiotensine (eca)
CHEN et al. Soybean protein‐derived hydrolysate affects blood pressure in spontaneously hypertensive rats
US20060234942A1 (en) Use of at least one $g(a)62 casein peptide with angiotensin i converting enzyme inhibiting activity for preparing medicines, food products and food complements
US6998259B1 (en) Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
López-Fandiño et al. Egg-protein-derived peptides with antihypertensive activity
US20050003999A9 (en) Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals
Hwang et al. Angiotensin I-converting enzyme inhibitory activity of protein hydrolysates from tuna broth
JP3383461B2 (ja) カゼイン加水分解物及びその製造方法
CHEN et al. Antihypertensive effect of an enzymatic hydrolysate of chicken essence residues
TWI457131B (zh) 胜肽及其於抑制血管收縮素轉換酶之用途
Hsu et al. Hydrolysates from tuna cooking juice as an anti-hypertensive agent
Pegg et al. Determination of hippuric acid by RP-HPLC using two different analytical columns-a short report
KR100470456B1 (ko) 혈압 저하 효과가 있는 카제인 단백질 분해물 및 그제조방법
Chamorro et al. Non-marine Animal Bioactive Peptides: Properties, Sources, and Applications
Abdulazeez et al. Isolation and Characterization of a New Angiotensin-converting Enzyme Inhibitory Peptide from Heterobronchus bidorsalis

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead