CA2415124A1 - Use of a liquid medicament in surgical high pressure liquid jet devices - Google Patents
Use of a liquid medicament in surgical high pressure liquid jet devices Download PDFInfo
- Publication number
- CA2415124A1 CA2415124A1 CA002415124A CA2415124A CA2415124A1 CA 2415124 A1 CA2415124 A1 CA 2415124A1 CA 002415124 A CA002415124 A CA 002415124A CA 2415124 A CA2415124 A CA 2415124A CA 2415124 A1 CA2415124 A1 CA 2415124A1
- Authority
- CA
- Canada
- Prior art keywords
- liquid
- pressure
- medicament
- jet
- biological structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3203—Fluid jet cutting instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- External Artificial Organs (AREA)
- Steroid Compounds (AREA)
Abstract
Tumours are, as a rule, removed surgically, by separating them from the tumo ur bed and finally rinsing the tumour bed with a cytotoxic fluid. The above represents two sequential working steps which prolongs surgery unnecessarily . The real disadvantage, however, is that the cytotoxic fluid in the post- operative treatment only reaches and kills superficial tumour cells. The use of a cytotoxic fluid by means of a high pressure liquid jet device is thus disclosed, for separation of the biological structure and concomitant treatment of the tumour bed.
Description
Description Use of a liquid medicament in surgical high-pressure liquid jet devices.
The invention relates to the use of a liquid medicament for treatment of dissection planes/resection surfaces at a biological structure and to the simultaneous separation of a biological structure. The invention relates in particular to the use of a cyto toxic liquid for combating of tumors or, respectively, of tumor cells. A
corresponding high-pressure liquid jet device for performing the new method according to the preamble of claim 3 is also subject matter of the present invention.
Such high-pressure liquid jet devices are employed in surgical hospitals together with the corresponding liquid medicaments.
Dissection planes/resection surfaces of the general kind are generated initially by operation and are in the following treated with medicaments, wherein the treatment with medicaments is limited to a swabbing, a coating, or a sprinkling of the dissection planes/resection surfaces with a medicament. The two processing steps are disposed therefore set apart in time, which prolongs the connected operating process and which interferes with the success of the treatment. A further disadvantage comprises that the following treatment of the dissection planes/resection planes is performed only superficially and the effective agents on the medicament can only penetrate very slowly into the tissue of the biological structure. This prolongs the healing process.
Dissection planes/resection surfaces of the particular kind are generated during operating procedures for the elimination of tumors, wherein the tumors then have to be treated also in a particular way. Tumors are benign growth or malignant growth, which growth embeds itself in the most different organs with the surrounding lymphatic tissue, fatty tissue, and connective tissue and the muscles or in a different biological structure. The malignant tumors grow very rapidly and thereby penetrate through the lymph channels, the lymphoducts and the lymph slots into the neighboring healthy tissue, where the malignant growth then forms metastases.
Such tumors are generally treated by operation, wherein the respective tumor carrying organ or another tumor carrying biological structure is separated out of the tumor bed. Despite a frequently radical expansion of the safety distance, it is thereby not to be prevented, that vital tumor cells in the lymph channels, the lymphoducts, and the lymph slots of the tumor bed tissue are not being captured by the operational cuts, wherein the vital tumor cells then remain in the tumor bed tissue or also step out from the former tumor bed during the operation. For this reason, the previous tumor bed is flushed out with a cyto toxic liquid in order to kill off tumor cells disposed in the tumor bed and remaining in the tumor bed tissue after the removal of the tumor carrying organ or of the other tumor carrying biological structure. The effective agents of the cyto toxic liquid however are brought to the location of the tumor action only very imprecise and inexact with this flushing method, such that only superficial tumor cells are reached and a considerable part of the tumor cells in the tumor bed or in the tumor bed tissue remain untreated. The risk of a tumor relapse is therefore very large, which is proven by the observed relapse rate. Certain successive steps such as for example a systematic chemotherapy or an irradiation cannot change this situation in any way.
Therefore the invention is based on the object to employ and to apply a liquid medicament for the treatment of dissection planes/resection surfaces, in particular a cyto toxic liquid for combating of tumors such that the liquid medicament reaches also deeper disposed regions of the dissection planes/resection surfaces at a biological structure.
This object is achieved as a method by the characterizing features of claim 1.
An advantageous embodiment results from the sub-claim 2. The object is resolved by the characterizing features of claim 3 with respect to a device, wherein claim 4 shows an advantageous embodiment.
The invention relates to the use of a liquid medicament for treatment of dissection planes/resection surfaces at a biological structure and to the simultaneous separation of a biological structure. The invention relates in particular to the use of a cyto toxic liquid for combating of tumors or, respectively, of tumor cells. A
corresponding high-pressure liquid jet device for performing the new method according to the preamble of claim 3 is also subject matter of the present invention.
Such high-pressure liquid jet devices are employed in surgical hospitals together with the corresponding liquid medicaments.
Dissection planes/resection surfaces of the general kind are generated initially by operation and are in the following treated with medicaments, wherein the treatment with medicaments is limited to a swabbing, a coating, or a sprinkling of the dissection planes/resection surfaces with a medicament. The two processing steps are disposed therefore set apart in time, which prolongs the connected operating process and which interferes with the success of the treatment. A further disadvantage comprises that the following treatment of the dissection planes/resection planes is performed only superficially and the effective agents on the medicament can only penetrate very slowly into the tissue of the biological structure. This prolongs the healing process.
Dissection planes/resection surfaces of the particular kind are generated during operating procedures for the elimination of tumors, wherein the tumors then have to be treated also in a particular way. Tumors are benign growth or malignant growth, which growth embeds itself in the most different organs with the surrounding lymphatic tissue, fatty tissue, and connective tissue and the muscles or in a different biological structure. The malignant tumors grow very rapidly and thereby penetrate through the lymph channels, the lymphoducts and the lymph slots into the neighboring healthy tissue, where the malignant growth then forms metastases.
Such tumors are generally treated by operation, wherein the respective tumor carrying organ or another tumor carrying biological structure is separated out of the tumor bed. Despite a frequently radical expansion of the safety distance, it is thereby not to be prevented, that vital tumor cells in the lymph channels, the lymphoducts, and the lymph slots of the tumor bed tissue are not being captured by the operational cuts, wherein the vital tumor cells then remain in the tumor bed tissue or also step out from the former tumor bed during the operation. For this reason, the previous tumor bed is flushed out with a cyto toxic liquid in order to kill off tumor cells disposed in the tumor bed and remaining in the tumor bed tissue after the removal of the tumor carrying organ or of the other tumor carrying biological structure. The effective agents of the cyto toxic liquid however are brought to the location of the tumor action only very imprecise and inexact with this flushing method, such that only superficial tumor cells are reached and a considerable part of the tumor cells in the tumor bed or in the tumor bed tissue remain untreated. The risk of a tumor relapse is therefore very large, which is proven by the observed relapse rate. Certain successive steps such as for example a systematic chemotherapy or an irradiation cannot change this situation in any way.
Therefore the invention is based on the object to employ and to apply a liquid medicament for the treatment of dissection planes/resection surfaces, in particular a cyto toxic liquid for combating of tumors such that the liquid medicament reaches also deeper disposed regions of the dissection planes/resection surfaces at a biological structure.
This object is achieved as a method by the characterizing features of claim 1.
An advantageous embodiment results from the sub-claim 2. The object is resolved by the characterizing features of claim 3 with respect to a device, wherein claim 4 shows an advantageous embodiment.
' CA 02415124 2003-O1-07 The present invention eliminates the recited disadvantages present in the state of the art. The particular advantage of the invention comprises that two properly separate operational steps are connected to each other and are combined.
On the one hand the liquid medicament is employed for the separation of the biological structure in an inventive way and thereby the same effect is achieved as is accomplished by the conventional sterile separation agents. The medicament begins already during the separation processs, that is in time overlap with the separation process, to act based on the employment of the medicament as a separating medium.
This shortens on the one hand the operating process and intensifies on the other hand the treatment process.
On the other hand the liquid medicament is applied in a novel way of application by being not any longer applied from the outside by washing over and flooding over the dissection planes/resection faces, but the liquid medicament is entered by way of injection into the adjoining tissue bed. This provides a new effect, because for the first time also deeper lying, for example bacteria or tumor cells can be reached and treated.
A high-pressure liquid device is a basis of the advantageous operating method and treatment method, wherein the high-pressure liquid device is capable of generating a fine liquid jet capable of separation. In addition such device comprises a steplessly changeable pressure automatic control device, wherein the pressure automatic control device permits a fine sensitive liquid jet automatic control.
Therewith it becomes possible in the present operating procedure to adapt the depth effect of the medicament stream jet to the special requirements of the disease case.
All these positive effects lead to the situation that all bacteria or all tissue cells affected with disease are treated optimally and combated in fact at their present location and therewith a relapse of the disease becomes excluded.
The invention is to be illustrated in more detail by way of an embodiment example.
A high-pressure liquid jet device is employed for performing of an operating procedure for example for removal of a tumor, wherein such high-pressure liquid jet device is described for example in the European patent document EP 0551920 B 1 and is known under the trade name HELIX HYDRO- jet. This high-pressure liquid jet device comprises essentially a pressure generator, a piston cylinder unit and a separating device in the shape of a special hand piece. A cartridge is shape matchingly inserted into the cylinder space of the piston cylinder unit, wherein the cartridge is filled with a separating liquid and wherein the cartridge is connected to the operation hand piece. The pressure medium of the pressure generator burdens and charges the cartridge during operation, whereby the separating liquid is pressed out of the cartridge and is transported to the operating hand piece, where the separating liquid exits under pressure in the form of a fine liquid jet. All device units of this high-pressure liquid jet device are constructed such and joined to each other such that on the one hand a continuous sterile chain is assured for the separating liquid and on the other hand the flowing out jet of liquid is capable of separating different biological structures in an intelligent way and in highest precision.
A cyto toxic liquid is employed as a separating liquid in accordance with the present invention, wherein the cyto toxic liquid is generally known and wherein the cyto toxic liquid is pressure stable up to 150 bar and wherein the cyto toxic liquid has a viscosity for allowing the cyto toxic liquid to form a jet.
The tumor affected organ or the other biological structure is separated from the surrounding lymph tissue, fat tissue and connective tissue as well as the muscles with the separating force of the beam or jet of the cyto toxic liquid in the course of the operation. This occurs at such safety distance relative to the tumor, that as many as possible metastases are separated also. Here the embedded tumor and all metastases exiting with the separating process from the lymph channels, from the lymphoducts, and the lymph slots into the tumor bed are necessarily already during the separating process contacted with the cyto toxic separating liquid such that the respective tumor cells are caused to die off. At the same time the cyto toxic liquid, caused by the high-pressure of the separating jet, penetrates deeply into the lymph channels, the lymphoducts, and in the lymph slots of the former tumor bed tissue and contacts also be the metastases present there. Thus also these corresponding tumor cells die off.
This treatment of the tumor cells occurring together with the separating process is to be designated as an interstitial chemotherapy, where the cyto toxic agents of the liquid are brought deeply into the tumor bed tissue with the aid of the high-pressure liquid jet device in a new form of application.
_g_
On the one hand the liquid medicament is employed for the separation of the biological structure in an inventive way and thereby the same effect is achieved as is accomplished by the conventional sterile separation agents. The medicament begins already during the separation processs, that is in time overlap with the separation process, to act based on the employment of the medicament as a separating medium.
This shortens on the one hand the operating process and intensifies on the other hand the treatment process.
On the other hand the liquid medicament is applied in a novel way of application by being not any longer applied from the outside by washing over and flooding over the dissection planes/resection faces, but the liquid medicament is entered by way of injection into the adjoining tissue bed. This provides a new effect, because for the first time also deeper lying, for example bacteria or tumor cells can be reached and treated.
A high-pressure liquid device is a basis of the advantageous operating method and treatment method, wherein the high-pressure liquid device is capable of generating a fine liquid jet capable of separation. In addition such device comprises a steplessly changeable pressure automatic control device, wherein the pressure automatic control device permits a fine sensitive liquid jet automatic control.
Therewith it becomes possible in the present operating procedure to adapt the depth effect of the medicament stream jet to the special requirements of the disease case.
All these positive effects lead to the situation that all bacteria or all tissue cells affected with disease are treated optimally and combated in fact at their present location and therewith a relapse of the disease becomes excluded.
The invention is to be illustrated in more detail by way of an embodiment example.
A high-pressure liquid jet device is employed for performing of an operating procedure for example for removal of a tumor, wherein such high-pressure liquid jet device is described for example in the European patent document EP 0551920 B 1 and is known under the trade name HELIX HYDRO- jet. This high-pressure liquid jet device comprises essentially a pressure generator, a piston cylinder unit and a separating device in the shape of a special hand piece. A cartridge is shape matchingly inserted into the cylinder space of the piston cylinder unit, wherein the cartridge is filled with a separating liquid and wherein the cartridge is connected to the operation hand piece. The pressure medium of the pressure generator burdens and charges the cartridge during operation, whereby the separating liquid is pressed out of the cartridge and is transported to the operating hand piece, where the separating liquid exits under pressure in the form of a fine liquid jet. All device units of this high-pressure liquid jet device are constructed such and joined to each other such that on the one hand a continuous sterile chain is assured for the separating liquid and on the other hand the flowing out jet of liquid is capable of separating different biological structures in an intelligent way and in highest precision.
A cyto toxic liquid is employed as a separating liquid in accordance with the present invention, wherein the cyto toxic liquid is generally known and wherein the cyto toxic liquid is pressure stable up to 150 bar and wherein the cyto toxic liquid has a viscosity for allowing the cyto toxic liquid to form a jet.
The tumor affected organ or the other biological structure is separated from the surrounding lymph tissue, fat tissue and connective tissue as well as the muscles with the separating force of the beam or jet of the cyto toxic liquid in the course of the operation. This occurs at such safety distance relative to the tumor, that as many as possible metastases are separated also. Here the embedded tumor and all metastases exiting with the separating process from the lymph channels, from the lymphoducts, and the lymph slots into the tumor bed are necessarily already during the separating process contacted with the cyto toxic separating liquid such that the respective tumor cells are caused to die off. At the same time the cyto toxic liquid, caused by the high-pressure of the separating jet, penetrates deeply into the lymph channels, the lymphoducts, and in the lymph slots of the former tumor bed tissue and contacts also be the metastases present there. Thus also these corresponding tumor cells die off.
This treatment of the tumor cells occurring together with the separating process is to be designated as an interstitial chemotherapy, where the cyto toxic agents of the liquid are brought deeply into the tumor bed tissue with the aid of the high-pressure liquid jet device in a new form of application.
_g_
Claims (4)
1. Use of a liquid medicament for treatment of dissection planes/resection surfaces at a biological structure and for the simultaneous separation of the biological structure, wherein the liquid medicament is capable of being subjected with a pressure of at least 50 bar and wherein the liquid medicament has a viscosity capable of forming a jet.
2. Use of a liquid medicament according to claim 1, characterized in that the liquid medicament is a cyto toxic liquid for combating tumors.
3. High-pressure liquid jet device for separating a biological structure and for simultaneous treatment of dissection planes/resection surfaces at a biological structure, characterized in that the high-pressure liquid jet device comprises a pressure generator, a storage container with a separating medium to be subjected to pressure from the pressure generator, and an operating hand piece, wherein the separating medium jet like flows out of the operating hand piece, wherein the separating medium is a liquid, pressure stable medicament capable of forming a jet.
4. High-pressure liquid jet device according to claim 3, characterized in that the liquid medicament is a cyto toxic liquid for combating of tumors.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10033283.8 | 2000-07-07 | ||
| DE10033283A DE10033283A1 (en) | 2000-07-07 | 2000-07-07 | Use of a liquid medicament for the treatment of dissection planes, resection areas on a biological structure and for simultaneous separation of the biological structure and high-pressure liquid jet device for carrying out the method |
| PCT/DE2001/002416 WO2002003871A1 (en) | 2000-07-07 | 2001-07-05 | Use of a liquid medicament in surgical high pressure liquid jet devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2415124A1 true CA2415124A1 (en) | 2002-01-17 |
Family
ID=7648274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002415124A Abandoned CA2415124A1 (en) | 2000-07-07 | 2001-07-05 | Use of a liquid medicament in surgical high pressure liquid jet devices |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1299039B1 (en) |
| JP (1) | JP2004502487A (en) |
| AT (1) | ATE346553T1 (en) |
| CA (1) | CA2415124A1 (en) |
| DE (2) | DE10033283A1 (en) |
| ES (1) | ES2277934T3 (en) |
| WO (1) | WO2002003871A1 (en) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59225049A (en) * | 1983-06-06 | 1984-12-18 | 株式会社 スギノマシン | Operation nozzle apparatus |
| CH676661A5 (en) * | 1988-06-16 | 1991-02-28 | Claude F Dr Rausis | |
| DE8814873U1 (en) * | 1988-11-26 | 1989-12-28 | Effner Gmbh, 1000 Berlin, De | |
| DE4200976C2 (en) * | 1992-01-16 | 1995-08-24 | Andreas Pein | Device for separating a biological structure, in particular human tissue |
| RU2085200C1 (en) * | 1993-11-11 | 1997-07-27 | Ростовский научно-исследовательский онкологический институт МЗ РФ | Method for preoperative treatment of rectum cancer |
| DE29501973U1 (en) * | 1995-02-08 | 1995-04-06 | Pein Andreas | Device for separating a biological structure |
| US5871462A (en) * | 1995-06-07 | 1999-02-16 | Hydrocision, Inc. | Method for using a fluid jet cutting system |
| RU2136221C1 (en) * | 1996-01-11 | 1999-09-10 | Глухов Александр Анатольевич | Method of resection of pancreas |
| FR2780268B1 (en) * | 1998-06-24 | 2000-09-29 | Saphir Medical Sa | TWO-WAY DISPENSING APPARATUS OF A STERILE WORKING LIQUID ACCORDING TO PREDETERMINED SEQUENCES FOR SURGICAL OR MEDICAL APPLICATIONS USING AT LEAST ONE HANDPIECE |
-
2000
- 2000-07-07 DE DE10033283A patent/DE10033283A1/en not_active Withdrawn
-
2001
- 2001-07-05 DE DE50111559T patent/DE50111559D1/en not_active Expired - Lifetime
- 2001-07-05 CA CA002415124A patent/CA2415124A1/en not_active Abandoned
- 2001-07-05 AT AT01957705T patent/ATE346553T1/en not_active IP Right Cessation
- 2001-07-05 WO PCT/DE2001/002416 patent/WO2002003871A1/en active IP Right Grant
- 2001-07-05 JP JP2002508332A patent/JP2004502487A/en active Pending
- 2001-07-05 ES ES01957705T patent/ES2277934T3/en not_active Expired - Lifetime
- 2001-07-05 EP EP01957705A patent/EP1299039B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1299039A1 (en) | 2003-04-09 |
| WO2002003871A8 (en) | 2002-05-16 |
| WO2002003871A1 (en) | 2002-01-17 |
| DE50111559D1 (en) | 2007-01-11 |
| EP1299039B1 (en) | 2006-11-29 |
| JP2004502487A (en) | 2004-01-29 |
| ATE346553T1 (en) | 2006-12-15 |
| ES2277934T3 (en) | 2007-08-01 |
| DE10033283A1 (en) | 2002-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |