CA2413742A1 - Activite de liaison au prion dans le serum et dans les proteines - Google Patents

Activite de liaison au prion dans le serum et dans les proteines Download PDF

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Publication number
CA2413742A1
CA2413742A1 CA002413742A CA2413742A CA2413742A1 CA 2413742 A1 CA2413742 A1 CA 2413742A1 CA 002413742 A CA002413742 A CA 002413742A CA 2413742 A CA2413742 A CA 2413742A CA 2413742 A1 CA2413742 A1 CA 2413742A1
Authority
CA
Canada
Prior art keywords
prpsc
factor
prion
plasminogen
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002413742A
Other languages
English (en)
Inventor
Michael Boris Fischer
Adriano Aguzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Zuerich
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2000/000849 external-priority patent/WO2001023425A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2413742A1 publication Critical patent/CA2413742A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des procédés et des outils destinés à concentrer, à détecter et à quantifier des protéines prion pathologiques ainsi que des agents à utiliser dans ladite détection et/ou dans la prévention ou dans le traitement des maladies à prion. Ces agents sont des facteurs dotés d'activités de liaison au prion que l'on trouve dans le sérum sanguin et dans le plasma sanguin.
CA002413742A 2000-06-26 2001-03-27 Activite de liaison au prion dans le serum et dans les proteines Abandoned CA2413742A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB00/00849 2000-06-26
PCT/IB2000/000849 WO2001023425A1 (fr) 1999-09-28 2000-06-26 Facteurs ayant une activite de liaison au prion dans du serum ou du plasma et agents permettant de detecter l'encephalopathie spongiforme transmissible
PCT/EP2001/003481 WO2002000713A1 (fr) 2000-06-26 2001-03-27 Activite de liaison au prion dans le serum et dans le plasma designes comme plasminogene et fibrinogene

Publications (1)

Publication Number Publication Date
CA2413742A1 true CA2413742A1 (fr) 2002-01-03

Family

ID=11003939

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002413742A Abandoned CA2413742A1 (fr) 2000-06-26 2001-03-27 Activite de liaison au prion dans le serum et dans les proteines

Country Status (6)

Country Link
EP (1) EP1294759A1 (fr)
JP (1) JP2004501626A (fr)
AU (1) AU2001250406A1 (fr)
BR (1) BR0111975A (fr)
CA (1) CA2413742A1 (fr)
WO (1) WO2002000713A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659076B2 (en) * 2002-02-28 2010-02-09 Microsens Biophage Limited Binding of pathological forms of prion proteins
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
AU2005209592B2 (en) 2004-09-30 2012-07-12 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
US7482172B2 (en) 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
CA2632662A1 (fr) * 2005-12-08 2007-06-14 South Dakota State University Procedes de propagation in vitro et de detection de prions infectieux
FR2940446A1 (fr) * 2008-12-22 2010-06-25 Lfb Biotechnologies Procede de detection d'une infection par prion
FR2973114A1 (fr) * 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
EP3064757B1 (fr) 2015-03-05 2018-11-14 Continental Automotive GmbH Procédé de fabrication d'un injecteur pour fluide et ledit injecteur

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925073C2 (de) * 1999-06-01 2001-07-19 Stefan Weiss Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung
MXPA01013186A (es) * 1999-06-23 2002-08-12 Caprion Pharmaceuticals Inc Peptidos de la proteina prion y sus usos.
AU5241100A (en) * 1999-09-28 2001-04-30 Universitat Zurich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis

Also Published As

Publication number Publication date
EP1294759A1 (fr) 2003-03-26
JP2004501626A (ja) 2004-01-22
AU2001250406A1 (en) 2002-01-08
WO2002000713A1 (fr) 2002-01-03
BR0111975A (pt) 2003-07-01

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead