CA2409063A1 - 7-substituted fused ring tetracycline compounds - Google Patents

7-substituted fused ring tetracycline compounds Download PDF

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Publication number
CA2409063A1
CA2409063A1 CA002409063A CA2409063A CA2409063A1 CA 2409063 A1 CA2409063 A1 CA 2409063A1 CA 002409063 A CA002409063 A CA 002409063A CA 2409063 A CA2409063 A CA 2409063A CA 2409063 A1 CA2409063 A1 CA 2409063A1
Authority
CA
Canada
Prior art keywords
compound
tetracycline
alkyl
compounds
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002409063A
Other languages
English (en)
French (fr)
Inventor
Mark L. Nelson
Laura Mcintyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2409063A1 publication Critical patent/CA2409063A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/02—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CA002409063A 2000-05-15 2001-05-10 7-substituted fused ring tetracycline compounds Abandoned CA2409063A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20415800P 2000-05-15 2000-05-15
US60/204,158 2000-05-15
PCT/US2001/015068 WO2001087824A2 (en) 2000-05-15 2001-05-10 7-substituted fused ring tetracycline compounds

Publications (1)

Publication Number Publication Date
CA2409063A1 true CA2409063A1 (en) 2001-11-22

Family

ID=22756861

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002409063A Abandoned CA2409063A1 (en) 2000-05-15 2001-05-10 7-substituted fused ring tetracycline compounds

Country Status (8)

Country Link
US (5) US6642270B2 (US07893282-20110222-C00013.png)
EP (2) EP1286954B1 (US07893282-20110222-C00013.png)
JP (2) JP2003533504A (US07893282-20110222-C00013.png)
AT (1) ATE264295T1 (US07893282-20110222-C00013.png)
AU (1) AU2001259701A1 (US07893282-20110222-C00013.png)
CA (1) CA2409063A1 (US07893282-20110222-C00013.png)
DE (1) DE60102815D1 (US07893282-20110222-C00013.png)
WO (1) WO2001087824A2 (US07893282-20110222-C00013.png)

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US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1263442A1 (en) * 2000-01-24 2002-12-11 Trustees Of Tufts College TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS
JP2004505012A (ja) * 2000-03-31 2004-02-19 トラスティーズ・オブ・タフツ・カレッジ ７−および９−カルバメート、尿素、チオ尿素、チオカルバメート、およびヘテロアリール−アミノ置換テトラサイクリン化合物
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WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
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US20080300424A1 (en) 2008-12-04
US7893282B2 (en) 2011-02-22
EP1286954B1 (en) 2004-04-14
WO2001087824A2 (en) 2001-11-22
US20040048835A1 (en) 2004-03-11
WO2001087824A3 (en) 2002-04-11
JP2013040173A (ja) 2013-02-28
DE60102815D1 (de) 2004-05-19
EP2308863A1 (en) 2011-04-13
US6642270B2 (en) 2003-11-04
EP1286954A2 (en) 2003-03-05
ATE264295T1 (de) 2004-04-15
US8288570B2 (en) 2012-10-16
US20060148765A1 (en) 2006-07-06
AU2001259701A1 (en) 2001-11-26
US20020045602A1 (en) 2002-04-18
US7612053B2 (en) 2009-11-03
US20110207951A1 (en) 2011-08-25
JP2003533504A (ja) 2003-11-11

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