CA2407259A1 - Nouveaux derives polycetides - Google Patents

Nouveaux derives polycetides Download PDF

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Publication number
CA2407259A1
CA2407259A1 CA002407259A CA2407259A CA2407259A1 CA 2407259 A1 CA2407259 A1 CA 2407259A1 CA 002407259 A CA002407259 A CA 002407259A CA 2407259 A CA2407259 A CA 2407259A CA 2407259 A1 CA2407259 A1 CA 2407259A1
Authority
CA
Canada
Prior art keywords
ethyl
methyl
hydrogen
hydroxyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002407259A
Other languages
English (en)
Inventor
Chaitan Khosla
Maria Fardis
Christopher Reeves
Daniel Chu
Daniel Santi
Andreas Schirmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2407259A1 publication Critical patent/CA2407259A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne de nouveaux polycétides, les cellules hôtes produisant ces nouveaux composés ainsi que leurs méthodes d'utilisation. Les composés selon la présente invention sont des polycétides cycliques (que l'on appelle également "macrolides" ou "macrolactones") dont la structure comprend la formule (I) et qui se lient à une protéine de liaison FK. Dans ladite formule (I), R?4¿ et R?5¿ sont chacun sélectionnés dans le groupe constitué d'hydrogène, méthyle, éthyle et méthoxy, pour autant que l'un au moins de R?4¿ et de R?5¿ représente hydrogène, méthyle ou éthyle. Comme expliqué plus en détail ci-après, les composés selon la présente invention possèdent des propriétés, notamment des profils d'activité de l'enzyme P450 favorables, lesquels sont souhaitables pour l'utilisation desdits composés comme médicaments.
CA002407259A 2000-05-17 2001-05-10 Nouveaux derives polycetides Abandoned CA2407259A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20482800P 2000-05-17 2000-05-17
US60/204,828 2000-05-17
US21817600P 2000-07-14 2000-07-14
US60/218,176 2000-07-14
US25296800P 2000-11-22 2000-11-22
US60/252,968 2000-11-22
PCT/US2001/015234 WO2001087884A2 (fr) 2000-05-17 2001-05-10 Nouveaux derives polycetides

Publications (1)

Publication Number Publication Date
CA2407259A1 true CA2407259A1 (fr) 2001-11-22

Family

ID=27394711

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002407259A Abandoned CA2407259A1 (fr) 2000-05-17 2001-05-10 Nouveaux derives polycetides

Country Status (5)

Country Link
EP (1) EP1282626A2 (fr)
JP (1) JP2004515459A (fr)
AU (2) AU6143201A (fr)
CA (1) CA2407259A1 (fr)
WO (1) WO2001087884A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007237187B2 (en) * 2002-07-16 2010-08-05 Biotica Technology Limited Production of polyketides
US7300942B2 (en) * 2002-07-16 2007-11-27 Biotica Technology Limited Production of polyketides and other natural products
RU2394036C2 (ru) 2004-12-20 2010-07-10 Вайет Аналоги рапамицина и их применение при лечении неврологических, пролиферативных и воспалительных заболеваний
MX2007007409A (es) 2004-12-20 2007-07-12 Wyeth Corp Derivados de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos.
TW201821076A (zh) 2016-11-10 2018-06-16 瑞士商諾華公司 Bmp增強劑
CN111253408B (zh) * 2020-02-11 2021-03-19 中国科学院南海海洋研究所 抗生素pactamide G及其制备方法和在制备抗菌药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142165A0 (en) * 1998-10-02 2002-03-10 Kosan Biosciences Inc Polyketide synthase enzymes and recombinant dna constructs therefor

Also Published As

Publication number Publication date
JP2004515459A (ja) 2004-05-27
WO2001087884A3 (fr) 2002-05-23
EP1282626A2 (fr) 2003-02-12
WO2001087884A2 (fr) 2001-11-22
AU6143201A (en) 2001-11-26
AU2001261432B2 (en) 2005-06-16

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