CA2403788A1 - Composes de liaison avec un recepteur et leurs methodes d'identification - Google Patents

Composes de liaison avec un recepteur et leurs methodes d'identification Download PDF

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Publication number
CA2403788A1
CA2403788A1 CA002403788A CA2403788A CA2403788A1 CA 2403788 A1 CA2403788 A1 CA 2403788A1 CA 002403788 A CA002403788 A CA 002403788A CA 2403788 A CA2403788 A CA 2403788A CA 2403788 A1 CA2403788 A1 CA 2403788A1
Authority
CA
Canada
Prior art keywords
protein
molecule
coupled receptor
binding
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002403788A
Other languages
English (en)
Inventor
John J. Nestor, Jr.
Carol J. Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Consensus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/813,448 external-priority patent/US20020142346A1/en
Priority claimed from US09/813,653 external-priority patent/US20020064770A1/en
Priority claimed from US09/813,651 external-priority patent/US20030018438A1/en
Application filed by Consensus Pharmaceuticals Inc filed Critical Consensus Pharmaceuticals Inc
Publication of CA2403788A1 publication Critical patent/CA2403788A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)

Abstract

L'invention concerne des compositions de composés de liaison destinées aux récepteurs couplés à la protéine G, et des méthodes permettant d'identifier les composés de liaison destinés audits récepteurs. L'invention concerne également des agents thérapeutiques comprenant lesdits composés.
CA002403788A 2000-03-21 2001-03-21 Composes de liaison avec un recepteur et leurs methodes d'identification Abandoned CA2403788A1 (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US19099600P 2000-03-21 2000-03-21
US19129900P 2000-03-21 2000-03-21
US19094600P 2000-03-21 2000-03-21
US60/191,299 2000-03-21
US60/190,946 2000-03-21
US60/190,996 2000-03-21
US09/813,448 2001-03-20
US09/813,651 2001-03-20
US09/813,448 US20020142346A1 (en) 2000-03-21 2001-03-20 Binding compounds and methods for identifying binding compounds
US09/813,653 US20020064770A1 (en) 2000-03-21 2001-03-20 Binding compounds and methods for identifying binding compounds
US09/813,653 2001-03-20
US09/813,651 US20030018438A1 (en) 2000-03-21 2001-03-20 Binding compounds and methods for identifying binding compounds
PCT/US2001/040345 WO2001070765A1 (fr) 2000-03-21 2001-03-21 Composes de liaison avec un recepteur et leurs methodes d'identification

Publications (1)

Publication Number Publication Date
CA2403788A1 true CA2403788A1 (fr) 2001-09-27

Family

ID=27558818

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002404139A Abandoned CA2404139A1 (fr) 2000-03-21 2001-03-21 Composes de fixation et procede d'identification de composes de fixation
CA002403784A Abandoned CA2403784A1 (fr) 2000-03-21 2001-03-21 Composes de liaison et procede d'identification de composes de liaison
CA002403788A Abandoned CA2403788A1 (fr) 2000-03-21 2001-03-21 Composes de liaison avec un recepteur et leurs methodes d'identification

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA002404139A Abandoned CA2404139A1 (fr) 2000-03-21 2001-03-21 Composes de fixation et procede d'identification de composes de fixation
CA002403784A Abandoned CA2403784A1 (fr) 2000-03-21 2001-03-21 Composes de liaison et procede d'identification de composes de liaison

Country Status (5)

Country Link
EP (3) EP1268523A2 (fr)
JP (2) JP2003528319A (fr)
AU (3) AU2001247675A1 (fr)
CA (3) CA2404139A1 (fr)
WO (3) WO2001071346A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056581A2 (fr) * 2003-12-10 2005-06-23 Universite De Lausanne Peptide susceptible de se lier specifiquement a un recepteur de chimiokine et son utilisation
JP2008516194A (ja) * 2004-10-04 2008-05-15 アルケミア リミティッド 選択的阻害剤
GB0724860D0 (en) * 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
WO2012022804A1 (fr) * 2010-08-19 2012-02-23 Probiodrug Ag Structure cristalline de glutaminyle cyclase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases

Also Published As

Publication number Publication date
AU2001253870A1 (en) 2001-10-03
WO2001070765A1 (fr) 2001-09-27
WO2001071346A3 (fr) 2002-09-12
WO2001070768A2 (fr) 2001-09-27
AU2001247674A1 (en) 2001-10-03
JP2003528319A (ja) 2003-09-24
EP1268523A2 (fr) 2003-01-02
WO2001070765A9 (fr) 2003-02-06
EP1268521A1 (fr) 2003-01-02
CA2404139A1 (fr) 2001-09-27
WO2001071346A2 (fr) 2001-09-27
EP1268520A2 (fr) 2003-01-02
WO2001070768A3 (fr) 2002-03-14
JP2004502134A (ja) 2004-01-22
AU2001247675A1 (en) 2001-10-03
CA2403784A1 (fr) 2001-09-27

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