CA2223038A1 - Recepteur du genre c5a a sept transmembranes - Google Patents

Recepteur du genre c5a a sept transmembranes Download PDF

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Publication number
CA2223038A1
CA2223038A1 CA002223038A CA2223038A CA2223038A1 CA 2223038 A1 CA2223038 A1 CA 2223038A1 CA 002223038 A CA002223038 A CA 002223038A CA 2223038 A CA2223038 A CA 2223038A CA 2223038 A1 CA2223038 A1 CA 2223038A1
Authority
CA
Canada
Prior art keywords
calr
polypeptide
expression
sequence
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002223038A
Other languages
English (en)
Inventor
Jeffrey J. Seilhamer
Janice Au-Young
Olga Bandman
Roger Coleman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2223038A1 publication Critical patent/CA2223038A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)

Abstract

L'invention porte: sur des séquences de nucléotides et d'acides aminés identifiant et codant pour un nouveau récepteur à sept transmembranes (CALR), du genre C5a, exprimé dans les mastocytes; sur des molécules antisens des séquences de nucléotides codant pour le CALR; sur des vecteurs d'expression servant à la production de CALR purifié; sur des anticorps capables de se fixer spécifiquement au CALR; sur des sondes d'hybridation ou des oligonucléotides servant à la détection des séquences de nucléotides codant pour le CALR; sur des tests diagnostiques utilisant les molécules d'acide nucléique codant pour le CALR; sur des cellules hôtes produites par génie génétique en vue de l'expression du CALR; et sur des antagonistes et des inhibiteurs du polypeptide CALR.
CA002223038A 1995-06-05 1996-06-03 Recepteur du genre c5a a sept transmembranes Abandoned CA2223038A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46235595A 1995-06-05 1995-06-05
US08/462,355 1995-06-05

Publications (1)

Publication Number Publication Date
CA2223038A1 true CA2223038A1 (fr) 1996-12-12

Family

ID=23836136

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002223038A Abandoned CA2223038A1 (fr) 1995-06-05 1996-06-03 Recepteur du genre c5a a sept transmembranes

Country Status (6)

Country Link
EP (1) EP0832231A2 (fr)
JP (1) JPH11507513A (fr)
AU (1) AU718311B2 (fr)
CA (1) CA2223038A1 (fr)
MX (1) MX9709338A (fr)
WO (1) WO1996039511A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803674A (zh) * 2016-06-10 2019-05-24 Io生物技术公司 Calr和jak2疫苗组合物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1921695A (en) * 1995-02-17 1996-09-04 Human Genome Sciences, Inc. Human g-protein coupled receptor
ES2287951T3 (es) * 1996-01-30 2007-12-16 The Scripps Research Institute Receptor asociado a proteina g con un dominio estracelular aumentado.
JPH1087700A (ja) * 1996-06-17 1998-04-07 Smithkline Beecham Corp Ｃ３ａ受容体およびＣ３ａを用いる治療およびスクリーニング方法
US6063596A (en) * 1997-12-11 2000-05-16 Incyte Pharmaceuticals, Inc. G-protein coupled receptors associated with immune response
WO2000008155A2 (fr) * 1998-08-07 2000-02-17 Incyte Pharmaceuticals, Inc. Proteines associees a un recepteur humain
EP1304921A2 (fr) * 2000-06-29 2003-05-02 Deltagen, Inc. Souris transgeniques contenant des interruptions de genes cibles
ES2561828T3 (es) 2002-01-25 2016-03-01 Novo Nordisk A/S Anticuerpos monoclonales contra bucles extracelulares de C5aR
RU2009110154A (ru) 2006-08-22 2010-09-27 Джи2 ИНФЛЕММЕЙШН ПТИ ЛТД (AU) АНТИТЕЛА ПРОТИВ C5aR С УЛУЧШЕННЫМИ СВОЙСТВАМИ
RU2010138612A (ru) 2008-02-20 2012-03-27 Джи2 ИНФЛЕММЕЙШН ПТИ ЛТД (AU) ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ C5аR
EP3798230B1 (fr) 2011-06-06 2022-08-03 Novo Nordisk A/S Anticorps thérapeutiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4855393A (en) * 1992-09-10 1994-03-29 New York University Polypeptides of g-coupled receptor proteins, and compositions and methods thereof
DK0630405T3 (da) * 1992-11-17 1999-01-04 Icos Corp Hidtil ukendt 7-transmembranreceptor benævnt V28

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803674A (zh) * 2016-06-10 2019-05-24 Io生物技术公司 Calr和jak2疫苗组合物

Also Published As

Publication number Publication date
AU718311B2 (en) 2000-04-13
MX9709338A (es) 1998-02-28
AU6327396A (en) 1996-12-24
JPH11507513A (ja) 1999-07-06
WO1996039511A3 (fr) 1997-01-09
WO1996039511A2 (fr) 1996-12-12
EP0832231A2 (fr) 1998-04-01

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EEER Examination request
FZDE Dead