CA2252369A1 - Antagonistes peptidiques derives des domaines transmembranaires des recepteurs couples aux proteines g - Google Patents

Antagonistes peptidiques derives des domaines transmembranaires des recepteurs couples aux proteines g Download PDF

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Publication number
CA2252369A1
CA2252369A1 CA 2252369 CA2252369A CA2252369A1 CA 2252369 A1 CA2252369 A1 CA 2252369A1 CA 2252369 CA2252369 CA 2252369 CA 2252369 A CA2252369 A CA 2252369A CA 2252369 A1 CA2252369 A1 CA 2252369A1
Authority
CA
Canada
Prior art keywords
peptide
protein
antagonist
coupled receptor
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2252369
Other languages
English (en)
Inventor
Michel Bouvier
Thomas P. Loisel
Terence E. Hebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Montreal
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2252369A1 publication Critical patent/CA2252369A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés peptidiques et peptidomimétiques qui agissent comme antagonistes contre les récepteurs couplés aux protéines G (GPCR). De nouveaux peptides courts, dérivés des domaines transmembranaires des GPCR, dont la taille se situe entre 15 et 20 restes d'acides aminés, peuvent être utilisés comme peptides modèles (peptides initiateurs) pour concevoir de nouveaux composés peptidiques et peptidiomimétiques qui sont des antagonistes de l'activité de ces derniers ou étroitement liés aux GPCR dont ils sont dérivés. Un peptide initiateur qui peut également être un antagoniste peptidique préféré pour le récepteur .beta.2-adrénergique de l'homme est le NH¿2?-GIIMGTFTLCWLPFFIVNIVH-COOH.
CA 2252369 1996-04-22 1997-04-21 Antagonistes peptidiques derives des domaines transmembranaires des recepteurs couples aux proteines g Abandoned CA2252369A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1589196P 1996-04-22 1996-04-22
US60/015,891 1996-04-22

Publications (1)

Publication Number Publication Date
CA2252369A1 true CA2252369A1 (fr) 1997-10-30

Family

ID=21774204

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2252369 Abandoned CA2252369A1 (fr) 1996-04-22 1997-04-21 Antagonistes peptidiques derives des domaines transmembranaires des recepteurs couples aux proteines g

Country Status (4)

Country Link
EP (1) EP0901525A2 (fr)
AU (1) AU2501297A (fr)
CA (1) CA2252369A1 (fr)
WO (1) WO1997040148A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0910640A2 (fr) * 1996-07-01 1999-04-28 Biosignal Inc. Peptides et composes peptidomimetiques affectant l'activite des recepteurs couples a la proteine g par modification de l'oligomerisation des recepteurs
AU5168700A (en) 1999-05-28 2000-12-18 Synaptic Pharmaceutical Corporation Dna encoding snorf33 receptor
EP1237909A2 (fr) * 1999-11-16 2002-09-11 PHARMACIA & UPJOHN COMPANY Recepteurs couples a une proteine g

Also Published As

Publication number Publication date
EP0901525A2 (fr) 1999-03-17
WO1997040148A3 (fr) 1997-12-18
AU2501297A (en) 1997-11-12
WO1997040148A2 (fr) 1997-10-30

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Legal Events

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