CA2400379A1 - Techniques de jeux ordonnes de microechantillons utilisant des nanocristaux semi-conducteurs - Google Patents

Techniques de jeux ordonnes de microechantillons utilisant des nanocristaux semi-conducteurs Download PDF

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Publication number
CA2400379A1
CA2400379A1 CA002400379A CA2400379A CA2400379A1 CA 2400379 A1 CA2400379 A1 CA 2400379A1 CA 002400379 A CA002400379 A CA 002400379A CA 2400379 A CA2400379 A CA 2400379A CA 2400379 A1 CA2400379 A1 CA 2400379A1
Authority
CA
Canada
Prior art keywords
array
ligand
nucleic acid
semiconductor nanocrystal
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002400379A
Other languages
English (en)
Inventor
Stephen A. Empedocles
Edith Y. Wong
Vince E. Phillips
R. Hugh Daniels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2400379A1 publication Critical patent/CA2400379A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne plusieurs techniques différentes permettant de réaliser des analyses avec différents types de jeux d'échantillons adressables utilisant des nanocristaux semi-conducteurs afin d'améliorer la détection. L'invention concerne également des techniques utilisant des nanocristaux semi-conducteurs avec, être autres, des jeux d'échantillons d'acides nucléiques, de protéines et de tissus. En utilisant plusieurs aspects utiles des nanocristaux semi-conducteurs, l'invention présente en outre plusieurs choix pour réaliser des analyses multiplexées. L'invention concerne aussi des techniques de détection consistant à compter individuellement les complexes comprenant des nanocristaux semi-conducteurs, pouvant s'utiliser afin d'étendre la gamme dynamique de détection.
CA002400379A 2000-02-16 2001-02-15 Techniques de jeux ordonnes de microechantillons utilisant des nanocristaux semi-conducteurs Abandoned CA2400379A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18284500P 2000-02-16 2000-02-16
US60/182,845 2000-02-16
US26629000P 2000-09-29 2000-09-29
US60/266,290 2000-09-29
PCT/US2001/004871 WO2001061040A1 (fr) 2000-02-16 2001-02-15 Techniques de jeux ordonnes de microechantillons utilisant des nanocristaux semi-conducteurs

Publications (1)

Publication Number Publication Date
CA2400379A1 true CA2400379A1 (fr) 2001-08-23

Family

ID=26878485

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002400379A Abandoned CA2400379A1 (fr) 2000-02-16 2001-02-15 Techniques de jeux ordonnes de microechantillons utilisant des nanocristaux semi-conducteurs

Country Status (5)

Country Link
EP (1) EP1255866A4 (fr)
JP (1) JP2003522962A (fr)
AU (1) AU2001238320A1 (fr)
CA (1) CA2400379A1 (fr)
WO (1) WO2001061040A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6759235B2 (en) 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
DE60137132D1 (en) * 2000-05-04 2009-02-05 Blood Res Center Are analytische systeme
US7118845B2 (en) 2000-06-15 2006-10-10 3M Innovative Properties Company Multiphoton photochemical process and articles preparable thereby
US7381516B2 (en) 2002-10-02 2008-06-03 3M Innovative Properties Company Multiphoton photosensitization system
US7005229B2 (en) 2002-10-02 2006-02-28 3M Innovative Properties Company Multiphoton photosensitization method
JP2002311027A (ja) * 2001-04-09 2002-10-23 Hitachi Software Eng Co Ltd ビーズ、ビーズ製造方法、フローサイトメータ及びプログラム
US20050118589A1 (en) * 2001-11-21 2005-06-02 Vann Charles S. Digital array
US20040002078A1 (en) 2001-12-05 2004-01-01 Sense Proteomic Limited Arrays
FR2840687B1 (fr) * 2002-06-05 2008-01-25 Bio Merieux Procede de detection simultanee de reactions d'hybridation et immunologiques et ses utilisations en diagnostic
AU2003272169A1 (en) * 2002-10-24 2004-05-13 Biacore Ab Assay with co-immobilized ligands
US7935541B2 (en) * 2007-09-28 2011-05-03 Fujifilm Corporation Immunochromatography method using fragmented antibody
JP5091075B2 (ja) * 2007-09-28 2012-12-05 富士フイルム株式会社 イムノクロマトグラフ方法
JP5091009B2 (ja) * 2008-05-27 2012-12-05 富士フイルム株式会社 イムノクロマトグラフ方法
JP2010004781A (ja) * 2008-06-25 2010-01-14 Canon Inc 核酸増幅装置およびそれを用いた核酸分析装置
GB2478734A (en) 2010-03-15 2011-09-21 Sense Proteomic Ltd Auto-antibody biomarkers of prostate cancer
GB201017520D0 (en) 2010-10-15 2010-12-01 Sense Proteomic Ltd Biomarkers
US9448231B2 (en) 2011-02-28 2016-09-20 Ventana Medical Systems, Inc. Application of quantum dots for nuclear staining

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
WO1992016657A1 (fr) * 1991-03-13 1992-10-01 E.I. Du Pont De Nemours And Company Procede d'identification d'un nucleotide present dans un acide nucleique en une position definie
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
EP1818417B1 (fr) * 1996-07-29 2014-02-12 Nanosphere, Inc. Nanoparticules comportant des oligonucléotides reliés et utilisations associées
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
NZ501917A (en) * 1997-07-22 2001-10-26 Qiagen Genomics Inc Method and apparatus for enzymatic reactions performed on nucleic acid arrays conducted at dew point
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
EP0990903B1 (fr) * 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Applications biologiques des nanocristaux semi-conducteurs
EP1113986A2 (fr) * 1998-09-18 2001-07-11 Massachusetts Institute Of Technology Gestion d'inventaire
CA2345376C (fr) * 1998-09-24 2010-03-16 Advanced Research And Technology Institute, Inc. Points quantiques luminescents solubles dans l'eau et bioconjugues obtenus a partir de ceux-ci
JP2002544488A (ja) * 1999-05-07 2002-12-24 クアンタム ドット コーポレイション 半導体ナノクリスタルを用いて分析物を検出する方法

Also Published As

Publication number Publication date
WO2001061040A1 (fr) 2001-08-23
EP1255866A1 (fr) 2002-11-13
AU2001238320A1 (en) 2001-08-27
JP2003522962A (ja) 2003-07-29
EP1255866A4 (fr) 2004-12-22

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Legal Events

Date Code Title Description
FZDE Discontinued