CA2398815C - Dry powder inhaler - Google Patents
Dry powder inhaler Download PDFInfo
- Publication number
- CA2398815C CA2398815C CA2398815A CA2398815A CA2398815C CA 2398815 C CA2398815 C CA 2398815C CA 2398815 A CA2398815 A CA 2398815A CA 2398815 A CA2398815 A CA 2398815A CA 2398815 C CA2398815 C CA 2398815C
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- inhaler
- bead
- dispersion chamber
- dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940112141 dry powder inhaler Drugs 0.000 title claims abstract description 16
- 239000011324 bead Substances 0.000 claims abstract description 192
- 239000006185 dispersion Substances 0.000 claims abstract description 127
- 239000000843 powder Substances 0.000 claims abstract description 95
- 239000002245 particle Substances 0.000 claims abstract description 85
- 239000000443 aerosol Substances 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims description 17
- 238000009472 formulation Methods 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 8
- 210000004072 lung Anatomy 0.000 claims description 6
- 230000003434 inspiratory effect Effects 0.000 claims description 4
- 238000009991 scouring Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 22
- 229940079593 drug Drugs 0.000 abstract description 21
- 238000005304 joining Methods 0.000 abstract description 2
- 239000003570 air Substances 0.000 description 78
- 238000013461 design Methods 0.000 description 18
- 230000008021 deposition Effects 0.000 description 9
- 230000009467 reduction Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 230000000739 chaotic effect Effects 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000012080 ambient air Substances 0.000 description 2
- 229960004436 budesonide Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000013583 drug formulation Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000012387 aerosolization Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000003562 lightweight material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000004482 other powder Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
- A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/43—General characteristics of the apparatus making noise when used correctly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/18—Coaxial flows, e.g. one flow within another
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/495,494 US6427688B1 (en) | 2000-02-01 | 2000-02-01 | Dry powder inhaler |
| US09/495,494 | 2000-02-01 | ||
| PCT/US2001/003248 WO2001056640A1 (en) | 2000-02-01 | 2001-01-31 | Dry powder inhaler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2398815A1 CA2398815A1 (en) | 2001-08-09 |
| CA2398815C true CA2398815C (en) | 2012-04-17 |
Family
ID=23968860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2398815A Expired - Fee Related CA2398815C (en) | 2000-02-01 | 2001-01-31 | Dry powder inhaler |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US6427688B1 (enExample) |
| EP (1) | EP1307256B1 (enExample) |
| JP (1) | JP4886143B2 (enExample) |
| AU (1) | AU2001233201A1 (enExample) |
| CA (1) | CA2398815C (enExample) |
| ES (1) | ES2432353T3 (enExample) |
| WO (1) | WO2001056640A1 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US6511676B1 (en) * | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
| US6651655B1 (en) | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
| US7069929B2 (en) * | 2000-02-01 | 2006-07-04 | Quadrant Technologies Limited | Dry powder inhaler |
| US7171965B2 (en) * | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
| US6427688B1 (en) * | 2000-02-01 | 2002-08-06 | Dura Pharmaceuticals, Icn. | Dry powder inhaler |
| US6595210B2 (en) * | 2000-11-27 | 2003-07-22 | Unisia Jecs Corporation | Inhalator for administering powder composition |
| FI20010538A0 (fi) * | 2001-03-16 | 2001-03-16 | Orion Corp | Jauheinhalaattori |
| GB2375308A (en) * | 2001-05-10 | 2002-11-13 | Cambridge Consultants | Inhalers |
| JP2005506855A (ja) * | 2001-05-10 | 2005-03-10 | ベクトゥラ デリバリー デバイシーズ リミテッド | 吸入器 |
| AU2003220125B2 (en) | 2002-03-20 | 2006-06-15 | Mannkind Corporation | Inhalation apparatus |
| JP2004195191A (ja) * | 2002-10-22 | 2004-07-15 | Akihiko Miyamoto | 呼子付喘息治療薬吸入器 |
| AU2002952683A0 (en) * | 2002-11-15 | 2002-11-28 | Commonwealth Scientific And Industrial Research Organisation | Apparatus for delivering dry aerosols to the respiratory tract |
| BR0316924A (pt) * | 2002-12-02 | 2005-10-18 | Univ Alberta | Dispositivo e método para desaglomeração de pó para inalação |
| EA007730B1 (ru) * | 2002-12-13 | 2006-12-29 | Оцука Фармасьютикал Ко., Лтд. | Ингаляционное устройство для транспульмонального введения |
| US6941947B2 (en) | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
| US20040206350A1 (en) * | 2002-12-19 | 2004-10-21 | Nektar Therapeutics | Aerosolization apparatus with non-circular aerosolization chamber |
| ES2383367T5 (es) * | 2003-04-09 | 2021-03-31 | Novartis Ag | Aparato de pulverización en forma de aerosol con protección de entrada de aire |
| US8869794B1 (en) | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
| GB0313604D0 (en) * | 2003-06-12 | 2003-07-16 | Britannia Pharmaceuticals Ltd | Delivery device for powdered medicament |
| EP1635762B1 (en) * | 2003-06-13 | 2021-03-03 | Civitas Therapeutics, Inc. | Low dose pharmaceutical powders for inhalation |
| US20050263153A1 (en) * | 2004-05-28 | 2005-12-01 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
| US7556035B2 (en) * | 2004-05-28 | 2009-07-07 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| EP2314298B1 (en) | 2004-08-23 | 2015-05-27 | MannKind Corporation | Microparticles comprising diketopiperazine salts for drug delivery |
| DE602005026837D1 (de) * | 2004-10-21 | 2011-04-21 | Basell Polyolefine Gmbh | 1-buten-polymer und herstellungsverfahren dafür |
| MX2007005522A (es) * | 2004-11-10 | 2007-07-05 | Cipla Ltd | Inhalador. |
| US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| PL2486942T3 (pl) | 2004-11-24 | 2019-05-31 | Meda Pharmaceuticals Inc | Kompozycje zawierające azelastynę oraz sposoby ich stosowania |
| FR2881118B1 (fr) * | 2005-01-25 | 2007-04-20 | Valois Sas | Dispositif de distribution de produit fluide. |
| FR2881117B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
| US7407156B2 (en) * | 2005-03-22 | 2008-08-05 | Toshiba Tec Kabushiki Kaisha | Sheet finishing apparatus |
| US8763605B2 (en) * | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
| AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
| GB0520794D0 (en) * | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| DE102005057685A1 (de) * | 2005-12-01 | 2007-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung |
| US7832397B2 (en) * | 2005-12-28 | 2010-11-16 | Philip Morris Usa Inc. | Aerosol powder delivery device |
| GB2433207B (en) * | 2006-02-21 | 2009-01-07 | Jianhe Li | Active suction actuated inhalers with timing devices |
| DK1986679T3 (da) | 2006-02-22 | 2017-11-20 | Mannkind Corp | Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof |
| WO2007103152A2 (en) * | 2006-03-03 | 2007-09-13 | Stc.Unm | Dry powder inhaler with aeroelastic dispersion mechanism |
| GB0611659D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
| AP2007000277S (en) * | 2007-03-28 | 2007-10-04 | Xerxes Rao | Cartridge for multidose inhaler |
| WO2009008001A2 (en) * | 2007-04-30 | 2009-01-15 | Sun Pharma Advanced Research Company Limited | Inhalation device |
| EP1992376A1 (en) * | 2007-05-16 | 2008-11-19 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
| EP3453418A1 (en) * | 2007-07-06 | 2019-03-13 | Manta Devices, LLC | Delivery device and related methods |
| MX2010006657A (es) | 2007-12-20 | 2010-10-05 | Astrazeneca Ab | Dispositivo y metodo para desagregar polvo 854. |
| EP2082762A1 (en) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International Gmbh | Inhaler |
| EP2082764A1 (en) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
| AU2009228074B2 (en) * | 2008-03-27 | 2015-01-22 | Mannkind Corporation | A dry powder inhalation system |
| GB2459257B (en) * | 2008-04-14 | 2012-12-19 | Alchemy Healthcare Ltd | Particulate dispenser |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CN103252007B (zh) | 2008-06-13 | 2016-06-22 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
| FR2933619B1 (fr) * | 2008-07-11 | 2012-03-30 | Valois Sas | Dispositif d'inhalation de poudre |
| FR2933620B1 (fr) * | 2008-07-11 | 2010-09-03 | Valois Sa | Dispositif d'inhalation de poudre. |
| WO2010011329A2 (en) * | 2008-07-23 | 2010-01-28 | Map Pharmaceuticals, Inc. | The delivery of powdered drug via inhalation |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| FR2936425B1 (fr) * | 2008-09-30 | 2012-02-17 | Valois Sas | Dispositif d'inhalation de poudre. |
| FR2936424B1 (fr) * | 2008-09-30 | 2012-01-20 | Valois Sas | Dispositif d'inhalation de poudre. |
| GB0818476D0 (en) * | 2008-10-09 | 2008-11-12 | Vectura Delivery Device Ltd | Inhaler |
| US9205240B2 (en) * | 2008-12-15 | 2015-12-08 | Profibrix B.V. | Powder delivery device |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| WO2010083042A1 (en) * | 2009-01-15 | 2010-07-22 | Manta Devices, Llc | Delivery device |
| EP2676695A3 (en) | 2009-03-11 | 2017-03-01 | MannKind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| FR2946538B1 (fr) | 2009-06-11 | 2012-08-03 | Valois Sas | Dispositif d'inhalation de poudre |
| FR2946537B1 (fr) * | 2009-06-11 | 2012-08-03 | Valois Sas | Dispositif d'inhalation de poudre |
| KR101875969B1 (ko) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| JP2012531961A (ja) | 2009-07-01 | 2012-12-13 | アストラゼネカ・アクチエボラーグ | 粉末を気流に引き込むためのディスペンサーおよび方法 |
| US10869638B2 (en) | 2009-09-25 | 2020-12-22 | Krispin Johan Leydon | Systems, devices and methods for rendering key respiratory measurements accessible to mobile digital devices |
| US9138167B1 (en) * | 2009-09-25 | 2015-09-22 | Krispin Johan Leydon | Means for rendering key respiratory measurements accessible to mobile digital devices |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| CA2779488A1 (en) | 2009-11-12 | 2011-05-19 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
| KR20120115264A (ko) * | 2009-11-13 | 2012-10-17 | 머크 샤프 앤드 돔 코포레이션 | 다수의 저장부를 가지는 투약 제품 및 건식 분말 흡입기 |
| WO2011080761A1 (en) | 2009-12-30 | 2011-07-07 | Thirumalai Anadampillai Aparna | An improved dry powder inhaler |
| WO2011116293A2 (en) | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
| USD635246S1 (en) * | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
| RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| AU2016222336B2 (en) * | 2010-06-21 | 2018-09-13 | Mannkind Corporation | Dry powder drug delivery system and methods |
| WO2012010877A2 (en) * | 2010-07-21 | 2012-01-26 | Astrazeneca Ab | New device |
| EP2646094B1 (en) * | 2010-11-29 | 2015-04-01 | Sanofi-Aventis Deutschland GmbH | Medicated module for an inhaler |
| JP6050758B2 (ja) * | 2010-12-07 | 2016-12-21 | レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 乾燥粉末吸入器及びその作動方法 |
| CN102553038B (zh) * | 2010-12-17 | 2014-07-02 | 陈庆堂 | 药粉吸嘴放置盒 |
| GB201021881D0 (en) | 2010-12-23 | 2011-02-02 | Profibrix Bv | Powder delivery device |
| CN105667994B (zh) | 2011-04-01 | 2018-04-06 | 曼金德公司 | 用于药物药盒的泡罩包装 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| US11103659B2 (en) | 2011-07-06 | 2021-08-31 | Manta Devices, Llc | Delivery device and related methods |
| DK2731573T3 (da) * | 2011-07-13 | 2020-01-02 | Pharmaxis Ltd | Forbedringer af indgivelsesanordninger |
| KR102002187B1 (ko) * | 2011-07-13 | 2019-07-19 | 파맥시스 엘티디 | 전달 장치에 관한 개선 |
| DK2731571T3 (da) | 2011-07-13 | 2020-02-17 | Pharmaxis Ltd | Forbedringer vedrørende leveringsanordninger |
| FR2979058B1 (fr) * | 2011-08-19 | 2013-08-30 | Valois Sas | Dispositif d'inhalation de poudre. |
| FR2979057B1 (fr) * | 2011-08-19 | 2013-08-30 | Valois Sas | Dispositif d'inhalation de poudre. |
| WO2013036881A2 (en) | 2011-09-07 | 2013-03-14 | Syphase, Llc | Dry powder inhalation device |
| WO2013063160A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
| US10463815B2 (en) * | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
| EP3421042B1 (en) | 2012-03-07 | 2024-04-17 | Beyond Air Ltd | Inhalation of nitric oxide for treating respiratory diseases |
| US9649454B2 (en) | 2012-05-03 | 2017-05-16 | Manta Devices, Llc | Delivery device and related methods |
| SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
| EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
| US9839756B2 (en) | 2012-11-27 | 2017-12-12 | Resmed Limited | Methods and apparatus for ionization therapy |
| EP2970149B1 (en) | 2013-03-15 | 2019-08-21 | MannKind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CN105451716A (zh) | 2013-07-18 | 2016-03-30 | 曼金德公司 | 热稳定性干粉药物组合物和方法 |
| US20150020806A1 (en) * | 2013-07-19 | 2015-01-22 | Merck Sharp & Dohme Corp. | Dry powder inhaler for delivering multipe agglomerate formulations |
| WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
| CN106794325B (zh) | 2014-02-21 | 2020-06-30 | 瑞必治公司 | 粉末吸入器、系统和方法 |
| NO2709641T3 (enExample) | 2014-03-10 | 2018-05-12 | ||
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| WO2015168572A2 (en) | 2014-05-02 | 2015-11-05 | Manta Devices, Llc | Delivery device and related methods |
| CN106470723B (zh) * | 2014-06-06 | 2019-12-13 | 格罗宁根大学 | 呼吸启动的干粉吸入器 |
| FR3025110B1 (fr) * | 2014-09-02 | 2016-12-23 | Univ Francois-Rabelais De Tours | Dispositif de pulverisation nasale de produit fluide |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| EP3244952A4 (en) * | 2015-01-14 | 2018-11-14 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
| EP3061501A1 (en) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Composition for the treatment of acne |
| CN107735135B (zh) | 2015-04-02 | 2020-06-26 | 希尔－罗姆服务私人有限公司 | 用于呼吸装置的歧管 |
| EP3117825A1 (en) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Oral formulation comprising berberine and morus alba extract |
| WO2017016316A1 (zh) * | 2015-07-28 | 2017-02-02 | 纳智源科技（唐山）有限责任公司 | 电子烟气动传感器、气流处理装置及电子烟 |
| WO2018071427A1 (en) * | 2016-10-11 | 2018-04-19 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
| CA3057683A1 (en) | 2017-03-28 | 2018-10-04 | Concentrx Pharmaceuticals, Inc. | Devices and methods for delivering dry powder medicaments |
| AU2019339644B2 (en) * | 2018-09-10 | 2021-11-11 | Cipla Limited | Single blister-strip based dispenser |
| DE102019219277A1 (de) * | 2019-12-10 | 2021-06-10 | Christian-Albrechts-Universität Zu Kiel | Pulverförmige Formulierungen zur Inhalation |
| US11289063B1 (en) * | 2020-07-17 | 2022-03-29 | Whistle Shield LLC | Hygienic whistle with enhanced sound-generating chamber |
| CN115105695B (zh) * | 2022-06-02 | 2023-05-16 | 宁波职业技术学院 | 一种哮喘呼吸器及哮喘呼吸器的使用方法 |
| CN118491823B (zh) * | 2024-07-17 | 2024-09-13 | 安徽墙煌科技股份有限公司 | 一种铝单板喷涂工艺 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE483136A (enExample) | 1947-09-04 | 1942-06-30 | ||
| US2470296A (en) * | 1948-04-30 | 1949-05-17 | Abbott Lab | Inhalator |
| US2534636A (en) | 1949-02-12 | 1950-12-19 | American Cyanamid Co | Powder dispenser |
| US2816549A (en) | 1956-11-16 | 1957-12-17 | Isaac E Webster | Dispensing device |
| US3362405A (en) * | 1964-04-06 | 1968-01-09 | Hamilton O. Hazel | Method and apparatus for admixing gas with solid particles |
| US3809084A (en) | 1970-02-16 | 1974-05-07 | American Cyanamid Co | Pressurized portable dispenser |
| SE367249B (enExample) * | 1971-11-10 | 1974-05-20 | T Griverus | |
| YU41046B (en) * | 1974-08-22 | 1986-10-31 | Schering Ag | Medicine inholating device |
| US3998226A (en) * | 1975-09-22 | 1976-12-21 | Edward G. Gomez | Inhalation device for encapsulated concentrates |
| FR2352556A1 (fr) | 1976-05-26 | 1977-12-23 | Pasteur Institut | Inhalateur de poudre |
| ZA811942B (en) * | 1980-03-25 | 1983-02-23 | H Malem | Nebulising apparatus |
| ES8206980A1 (es) * | 1980-10-30 | 1982-09-01 | Riker Laboratories Inc | Un dispositivo para facilitar la inhalacion oral de medica- mentos en forma de polvo |
| US4509515A (en) | 1982-02-23 | 1985-04-09 | Fisons Plc | Inhalation device |
| ES286422Y (es) * | 1982-10-08 | 1986-09-16 | Glaxo Group Limited | Dispositivo para administrar medicamentos a pacientes |
| AT384552B (de) * | 1985-08-01 | 1987-12-10 | Hurka Wilhelm | Inhalationsgeraet zur dosierung und verteilung von festkoerpern in die atemluft |
| US4653494A (en) * | 1985-12-20 | 1987-03-31 | Ruderian Max J | Nasal inhalation system |
| US4790305A (en) * | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
| GB8909891D0 (en) | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| EP0407028B2 (en) | 1989-05-31 | 1999-07-07 | FISONS plc | Medicament inhalation device and formulation |
| US5176132A (en) * | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
| FI84698C (fi) | 1989-06-16 | 1992-01-10 | Huhtamaeki Oy | Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform. |
| IT1230313B (it) * | 1989-07-07 | 1991-10-18 | Somova Spa | Inalatore per medicamenti in capsule. |
| US5042467A (en) * | 1990-03-28 | 1991-08-27 | Trudell Medical | Medication inhaler with fitting having a sonic signalling device |
| NZ250988A (en) * | 1990-06-14 | 1995-09-26 | Rhone Poulenc Rorer Ltd | Powder inhaler: swirling chamber with anti-static walls |
| US5042472A (en) | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
| DE59107894D1 (de) | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| US5797391A (en) | 1991-03-28 | 1998-08-25 | Rhone-Poulenc Rorer Limited | Inhaler |
| US5492112A (en) | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| DE4211475A1 (de) * | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| EP0558879B1 (en) | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
| SE9302550D0 (sv) * | 1993-07-30 | 1993-07-30 | Ernst Hoerlin | Powder inhaler |
| US5727546A (en) * | 1993-08-18 | 1998-03-17 | Fisons Plc | Powder inhaler with breath flow regulation valve |
| DE4340768A1 (de) * | 1993-11-30 | 1995-06-01 | Bayer Ag | Vorrichtung zum Inhalieren |
| DE59409856D1 (de) * | 1994-05-19 | 2001-10-11 | Pari Gmbh | Vorrichtung zur Trocknung und Pufferung von Aerosolen |
| US5714007A (en) | 1995-06-06 | 1998-02-03 | David Sarnoff Research Center, Inc. | Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate |
| SE504458C2 (sv) | 1995-06-21 | 1997-02-17 | Lars Gunnar Nilsson | Inhalator för elektrisk dosering av substanser |
| US5642727A (en) | 1995-07-25 | 1997-07-01 | David Sarnoff Research Center, Inc. | Inhaler apparatus using a tribo-electric charging technique |
| US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
| SE9600306D0 (sv) * | 1996-01-29 | 1996-01-29 | Ernst Hoerlin | Capsule opening arrangement for use in a powder inhaler |
| US6470884B2 (en) * | 1996-01-29 | 2002-10-29 | Aventis Pharma Limited | Capsule opening arrangement for use in a powder inhaler |
| GB9626233D0 (en) * | 1996-12-18 | 1997-02-05 | Chawla Brinda P S | Medicament packaging and deliveery device |
| US6073629A (en) * | 1997-09-25 | 2000-06-13 | Norton Healthcare Ltd. | Inhaler spacer |
| GB9720283D0 (en) | 1997-09-25 | 1997-11-26 | Norton Healthcare Ltd | Inhaler spacer |
| US6125998A (en) * | 1997-12-17 | 2000-10-03 | Batista; Christina | Whistle case |
| US6096368A (en) | 1998-02-19 | 2000-08-01 | Delsys Pharmaceutical Corporation | Bead transporter chucks using repulsive field guidance and method |
| US6063194A (en) | 1998-06-10 | 2000-05-16 | Delsys Pharmaceutical Corporation | Dry powder deposition apparatus |
| US6615826B1 (en) * | 1999-02-26 | 2003-09-09 | 3M Innovative Properties Company | Slow spray metered dose inhaler |
| GB9905538D0 (en) | 1999-03-10 | 1999-05-05 | Glaxo Group Ltd | A device |
| US6427688B1 (en) | 2000-02-01 | 2002-08-06 | Dura Pharmaceuticals, Icn. | Dry powder inhaler |
| WO2002013897A2 (en) | 2000-08-14 | 2002-02-21 | Advanced Inhalation Research, Inc. | Inhalation device and method |
| US6722364B2 (en) * | 2001-01-12 | 2004-04-20 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
-
2000
- 2000-02-01 US US09/495,494 patent/US6427688B1/en not_active Expired - Lifetime
-
2001
- 2001-01-31 WO PCT/US2001/003248 patent/WO2001056640A1/en not_active Ceased
- 2001-01-31 ES ES01905307T patent/ES2432353T3/es not_active Expired - Lifetime
- 2001-01-31 CA CA2398815A patent/CA2398815C/en not_active Expired - Fee Related
- 2001-01-31 US US09/773,261 patent/US6715486B2/en not_active Expired - Lifetime
- 2001-01-31 EP EP01905307.3A patent/EP1307256B1/en not_active Expired - Lifetime
- 2001-01-31 JP JP2001556536A patent/JP4886143B2/ja not_active Expired - Fee Related
- 2001-01-31 AU AU2001233201A patent/AU2001233201A1/en not_active Abandoned
-
2004
- 2004-02-19 US US10/782,449 patent/US6971384B2/en not_active Expired - Lifetime
-
2005
- 2005-09-12 US US11/224,406 patent/US20060005833A1/en not_active Abandoned
-
2008
- 2008-12-04 US US12/328,657 patent/US7958890B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1307256B1 (en) | 2013-07-24 |
| US20090084380A1 (en) | 2009-04-02 |
| US6715486B2 (en) | 2004-04-06 |
| US20010027790A1 (en) | 2001-10-11 |
| US7958890B2 (en) | 2011-06-14 |
| EP1307256A1 (en) | 2003-05-07 |
| EP1307256A4 (en) | 2006-04-12 |
| JP4886143B2 (ja) | 2012-02-29 |
| JP2004502472A (ja) | 2004-01-29 |
| US20040163644A1 (en) | 2004-08-26 |
| WO2001056640A1 (en) | 2001-08-09 |
| US20060005833A1 (en) | 2006-01-12 |
| WO2001056640A9 (en) | 2002-10-24 |
| AU2001233201A1 (en) | 2001-08-14 |
| ES2432353T3 (es) | 2013-12-02 |
| US6971384B2 (en) | 2005-12-06 |
| US6427688B1 (en) | 2002-08-06 |
| CA2398815A1 (en) | 2001-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2398815C (en) | Dry powder inhaler | |
| US11471623B2 (en) | Powder dispersion methods and devices | |
| RU2127612C1 (ru) | Порошковый ингалятор | |
| FI84698C (fi) | Anordning foer finfoerdelning av agglomerat av en enkeldos av ett laekemedelpreparat i pulverform. | |
| EP1294421B1 (en) | Dry Powder Inhaler | |
| AU2008341217B2 (en) | Dispenser and method for entraining powder in an airflow 537 | |
| US10682476B2 (en) | Powder inhaler, system and methods | |
| US20070125375A1 (en) | Device and method for deagglomeration of powder for inhalation | |
| US20250108180A1 (en) | Powder dispersion methods and devices |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190131 |