CA2396865C - Farnesyl protein transferase inhibitors for treating breast cancer - Google Patents
Farnesyl protein transferase inhibitors for treating breast cancer Download PDFInfo
- Publication number
- CA2396865C CA2396865C CA002396865A CA2396865A CA2396865C CA 2396865 C CA2396865 C CA 2396865C CA 002396865 A CA002396865 A CA 002396865A CA 2396865 A CA2396865 A CA 2396865A CA 2396865 C CA2396865 C CA 2396865C
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- CA
- Canada
- Prior art keywords
- 6alkyl
- hydrogen
- formula
- 6alkyloxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title claims abstract description 28
- 206010006187 Breast cancer Diseases 0.000 title claims abstract description 25
- 208000026310 Breast neoplasm Diseases 0.000 title description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
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- 150000003839 salts Chemical class 0.000 claims description 23
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- 238000007911 parenteral administration Methods 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 119
- 239000001257 hydrogen Substances 0.000 description 119
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 74
- -1 C1_6alkyloxy Chemical group 0.000 description 63
- 150000003254 radicals Chemical class 0.000 description 61
- 125000005843 halogen group Chemical group 0.000 description 54
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 24
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- 125000002883 imidazolyl group Chemical group 0.000 description 7
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- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 description 6
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00200373 | 2000-02-04 | ||
| EP00200373.9 | 2000-02-04 | ||
| PCT/EP2001/001032 WO2001056552A2 (en) | 2000-02-04 | 2001-02-01 | Farnesyl protein transferase inhibitors for treating breast cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2396865A1 CA2396865A1 (en) | 2001-08-09 |
| CA2396865C true CA2396865C (en) | 2009-04-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002396865A Expired - Lifetime CA2396865C (en) | 2000-02-04 | 2001-02-01 | Farnesyl protein transferase inhibitors for treating breast cancer |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20030027839A1 (enExample) |
| EP (1) | EP1255537B1 (enExample) |
| JP (1) | JP5491681B2 (enExample) |
| AT (1) | ATE323474T1 (enExample) |
| AU (1) | AU2001233726A1 (enExample) |
| CA (1) | CA2396865C (enExample) |
| CY (1) | CY1105477T1 (enExample) |
| DE (1) | DE60118889T2 (enExample) |
| DK (1) | DK1255537T3 (enExample) |
| ES (1) | ES2262626T3 (enExample) |
| PT (1) | PT1255537E (enExample) |
| SI (1) | SI1255537T1 (enExample) |
| WO (1) | WO2001056552A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7342016B2 (en) * | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| DE60230017D1 (de) * | 2001-02-15 | 2009-01-08 | Janssen Pharmaceutica Nv | Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen |
| CN1617755A (zh) * | 2001-11-30 | 2005-05-18 | 先灵公司 | 法尼基蛋白转移酶抑制剂和其它抗肿瘤剂联合使用在制备抗癌症的药物中的应用 |
| US7102251B2 (en) * | 2003-08-22 | 2006-09-05 | Distributed Power, Inc. | Bi-directional multi-port inverter with high frequency link transformer |
| CA2544421A1 (en) * | 2003-11-06 | 2005-05-26 | Schering Corporation | Combination of a farnesyl transferase inhibitor with an antihormonal agent for the treatment of breast cancer |
| JP2007516258A (ja) | 2003-12-12 | 2007-06-21 | ワイス | 心臓血管の疾患治療に有用なキノリン誘導体 |
| CA2559285A1 (en) * | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| WO2005089518A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Uch-l1 expression and cancer therapy |
| WO2005089515A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| JP2007529555A (ja) * | 2004-03-18 | 2007-10-25 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | シヌクレイノパチーを治療する方法 |
| US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
| US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
| US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
| EP2545919A1 (en) | 2005-12-23 | 2013-01-16 | Link Medicine Corporation | Treatment of synucleinopathies |
| US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
| CA2743717A1 (en) * | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
| EP2288195B1 (en) * | 2009-08-20 | 2019-10-23 | Samsung Electronics Co., Ltd. | Method and apparatus for operating a base station in a wireless communication system |
| KR20150070347A (ko) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | Ror-감마-t의 메틸렌 결합 퀴놀리닐 조절제 |
| ES2628365T3 (es) | 2012-10-16 | 2017-08-02 | Janssen Pharmaceutica N.V. | Moduladores de quinolinilo unidos a fenilo de ROR-GAMA-T |
| HK1213250A1 (zh) | 2012-10-16 | 2016-06-30 | Janssen Pharmaceutica, N.V. | RORγT的雜芳基連接的喹啉基調節劑 |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| AU2014334619A1 (en) | 2013-10-15 | 2016-04-21 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORyt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| KR20160068956A (ko) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | RORyT의 퀴놀리닐 조절제 |
| HUE057306T2 (hu) | 2015-08-17 | 2022-04-28 | Kura Oncology Inc | Módszerek rákos páciensek kezelésére farneziltranszferáz inhibitorokkal |
| TW201818965A (zh) | 2016-11-03 | 2018-06-01 | 美商庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶（ｆａｒｎｅｓｙｌ ｔｒａｎｓｆｅｒａｓｅ）抑制劑治療癌症病患之方法 |
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| SI1162201T1 (sl) * | 1995-12-08 | 2006-08-31 | Janssen Pharmaceutica Nv | (Imidazol-5-il)metil-2-kinolinonski derivati kot inhibitorji farnezil protein transferaze |
| US5874442A (en) * | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| US5994364A (en) * | 1996-09-13 | 1999-11-30 | Schering Corporation | Tricyclic antitumor farnesyl protein transferase inhibitors |
| TW591030B (en) * | 1997-03-10 | 2004-06-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles |
| KR100520401B1 (ko) * | 1997-04-25 | 2005-10-12 | 얀센 파마슈티카 엔.브이. | 파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논 |
| US5925639A (en) * | 1997-06-17 | 1999-07-20 | Schering Corporation | Keto amide derivatives useful as farnesyl protein transferase inhibitors |
| US5852034A (en) * | 1997-06-17 | 1998-12-22 | Schering Corporation | Benzo(5,6)cycloheptapyridine cyclic ureas and lactams useful as farnesyl protein transferase inhibitors |
| US6096757A (en) * | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
| US6410534B1 (en) * | 1998-07-02 | 2002-06-25 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| PT1094839E (pt) * | 1998-07-06 | 2003-09-30 | Janssen Pharmaceutica Nv | Inibidores da proteina farnesil transferase com propriedades de radiossensibilizacao (in vivo) |
| AU4925199A (en) * | 1998-08-27 | 2000-03-21 | Pfizer Products Inc. | Quinolin-2-one derivatives useful as anticancer agents |
| EA004542B1 (ru) * | 1998-12-23 | 2004-06-24 | Янссен Фармацевтика Н.В. | 1, 2-аннелированные производные хинолина |
| AU2292801A (en) * | 1999-12-22 | 2001-07-03 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for treatment of breast cancer |
| EP1267848B1 (en) * | 2000-02-24 | 2007-10-17 | Janssen Pharmaceutica N.V. | Dosing regimen comprising a farnesyl protein transferase inhibitor for the treatment of cancer |
| EP1261374A2 (en) * | 2000-02-29 | 2002-12-04 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with further anti-cancer agents |
| US20020022633A1 (en) * | 2000-06-30 | 2002-02-21 | Williams Theresa M. | Inhibitors of prenyl-protein transferase |
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2001
- 2001-02-01 SI SI200130572T patent/SI1255537T1/sl unknown
- 2001-02-01 DK DK01905717T patent/DK1255537T3/da active
- 2001-02-01 EP EP01905717A patent/EP1255537B1/en not_active Expired - Lifetime
- 2001-02-01 CA CA002396865A patent/CA2396865C/en not_active Expired - Lifetime
- 2001-02-01 PT PT01905717T patent/PT1255537E/pt unknown
- 2001-02-01 US US10/203,083 patent/US20030027839A1/en not_active Abandoned
- 2001-02-01 AT AT01905717T patent/ATE323474T1/de active
- 2001-02-01 DE DE60118889T patent/DE60118889T2/de not_active Expired - Lifetime
- 2001-02-01 ES ES01905717T patent/ES2262626T3/es not_active Expired - Lifetime
- 2001-02-01 WO PCT/EP2001/001032 patent/WO2001056552A2/en not_active Ceased
- 2001-02-01 JP JP2001556244A patent/JP5491681B2/ja not_active Expired - Lifetime
- 2001-02-01 AU AU2001233726A patent/AU2001233726A1/en not_active Abandoned
-
2004
- 2004-04-06 US US10/818,767 patent/US20040192726A1/en not_active Abandoned
-
2006
- 2006-07-18 CY CY20061100995T patent/CY1105477T1/el unknown
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2008
- 2008-09-16 US US12/211,705 patent/US20090018164A1/en not_active Abandoned
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2011
- 2011-01-06 US US12/985,579 patent/US20110098318A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001233726A1 (en) | 2001-08-14 |
| SI1255537T1 (sl) | 2006-10-31 |
| JP2003521509A (ja) | 2003-07-15 |
| WO2001056552A3 (en) | 2002-04-25 |
| ATE323474T1 (de) | 2006-05-15 |
| US20090018164A1 (en) | 2009-01-15 |
| PT1255537E (pt) | 2006-09-29 |
| ES2262626T3 (es) | 2006-12-01 |
| EP1255537A2 (en) | 2002-11-13 |
| DE60118889D1 (de) | 2006-05-24 |
| DE60118889T2 (de) | 2006-11-30 |
| WO2001056552A2 (en) | 2001-08-09 |
| EP1255537B1 (en) | 2006-04-19 |
| DK1255537T3 (da) | 2006-08-21 |
| CA2396865A1 (en) | 2001-08-09 |
| US20040192726A1 (en) | 2004-09-30 |
| CY1105477T1 (el) | 2010-04-28 |
| US20030027839A1 (en) | 2003-02-06 |
| US20110098318A1 (en) | 2011-04-28 |
| JP5491681B2 (ja) | 2014-05-14 |
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