CA2393437C - Exo-s-mecamylamine formulation and use in treatment - Google Patents
Exo-s-mecamylamine formulation and use in treatment Download PDFInfo
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- CA2393437C CA2393437C CA002393437A CA2393437A CA2393437C CA 2393437 C CA2393437 C CA 2393437C CA 002393437 A CA002393437 A CA 002393437A CA 2393437 A CA2393437 A CA 2393437A CA 2393437 C CA2393437 C CA 2393437C
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- mecamylamine
- exo
- weight
- pharmaceutically acceptable
- human
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- 238000001262 western blot Methods 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11253498P | 1998-12-16 | 1998-12-16 | |
| US60/112,534 | 1998-12-16 | ||
| PCT/US1999/030153 WO2000035279A1 (en) | 1998-12-16 | 1999-12-16 | Exo-s-mecamylamine formulation and use in treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2393437A1 CA2393437A1 (en) | 2000-06-22 |
| CA2393437C true CA2393437C (en) | 2009-12-15 |
Family
ID=22344414
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002393437A Expired - Fee Related CA2393437C (en) | 1998-12-16 | 1999-12-16 | Exo-s-mecamylamine formulation and use in treatment |
| CA002393442A Abandoned CA2393442A1 (en) | 1998-12-16 | 1999-12-16 | Exo-r-mecamylamine formulation and use in treatment |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002393442A Abandoned CA2393442A1 (en) | 1998-12-16 | 1999-12-16 | Exo-r-mecamylamine formulation and use in treatment |
Country Status (12)
| Country | Link |
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| US (1) | US20020016370A1 (https=) |
| EP (3) | EP1139743B1 (https=) |
| JP (5) | JP2002532393A (https=) |
| AT (2) | ATE320711T1 (https=) |
| AU (2) | AU2368600A (https=) |
| CA (2) | CA2393437C (https=) |
| CY (1) | CY1108577T1 (https=) |
| DE (2) | DE69939498D1 (https=) |
| DK (2) | DK1634498T3 (https=) |
| ES (2) | ES2313187T3 (https=) |
| PT (2) | PT1634498E (https=) |
| WO (2) | WO2000035279A1 (https=) |
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| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US7045534B2 (en) | 2002-02-12 | 2006-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of reducing angiogenesis |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| ES2294480T3 (es) * | 2003-03-14 | 2008-04-01 | Agi Therapeutics Research Limited | Tratamiento de afecciones instestinales con n-2,3,3-tetrametilbiciclo(2.1.1)heptan-2-amina. |
| US20070224284A1 (en) * | 2004-03-12 | 2007-09-27 | John Devane | Methods and compositions comprising at least one alpha3 beta4 nAChR antagonist or pharmaceutically acceptable salt thereof |
| DE10318714B4 (de) * | 2003-04-25 | 2006-03-23 | Hf Arzneimittelforschung Gmbh | Wirkstoff-Kombinationen und Therapien zur Bekämpfung des Alkoholmissbrauches |
| JP5254616B2 (ja) | 2004-09-13 | 2013-08-07 | クロノ セラピューティクス、インコーポレイテッド | 生物学的同調性（ｂｉｏｓｙｎｃｈｒｏｎｏｕｓ）経皮的薬物送達 |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| CA2633655A1 (en) * | 2005-12-19 | 2007-07-05 | Comentis, Inc. | Topical mecamylamine formulations for ocular administration and uses therof |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| CL2007002903A1 (es) * | 2006-10-09 | 2008-04-18 | Smithkline Beecham Corp | Composicion que comprende a) al menos un antagonista del receptor nicotinico a3beta4; y b) al menos un metabolito de la nicotina; y uso para reducir los sintomas de abstinencia de nicotina y/o el uso del tabaco. |
| US20080242947A1 (en) * | 2007-03-30 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Configuring software for effective health monitoring or the like |
| US20090119154A1 (en) * | 2007-11-07 | 2009-05-07 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Determining a demographic characteristic based on computational user-health testing of a user interaction with advertiser-specified content |
| US20090018407A1 (en) * | 2007-03-30 | 2009-01-15 | Searete Llc, A Limited Corporation Of The State Of Delaware | Computational user-health testing |
| US20090005654A1 (en) * | 2007-03-30 | 2009-01-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational user-health testing |
| US20080243005A1 (en) * | 2007-03-30 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational user-health testing |
| US20080242948A1 (en) * | 2007-03-30 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Effective low-profile health monitoring or the like |
| US20090005653A1 (en) * | 2007-03-30 | 2009-01-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational user-health testing |
| US20080242952A1 (en) * | 2007-03-30 | 2008-10-02 | Searete Llc, A Limited Liablity Corporation Of The State Of Delaware | Effective response protocols for health monitoring or the like |
| US20080242951A1 (en) * | 2007-03-30 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Effective low-profile health monitoring or the like |
| US20080242949A1 (en) * | 2007-03-30 | 2008-10-02 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational user-health testing |
| US20080319276A1 (en) * | 2007-03-30 | 2008-12-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational user-health testing |
| EP2322168A1 (en) | 2007-04-02 | 2011-05-18 | Parkinson's Institute | Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments |
| WO2009143403A1 (en) * | 2008-05-23 | 2009-11-26 | Targacept, Inc. | Combination therapy for the management hypertension |
| AT507187B1 (de) | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | Inhalator |
| CN102548550A (zh) * | 2009-07-14 | 2012-07-04 | 塔加西普特公司 | 外型-s-美卡拉明用于治疗的方法、用途和化合物 |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| PE20130775A1 (es) * | 2010-05-27 | 2013-07-21 | Targacept Inc | Antagonistas no competitivos de receptores nicotinicos |
| EP2672847B1 (de) | 2011-02-11 | 2015-04-22 | Batmark Limited | Inhalatorkomponente |
| AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| KR102196913B1 (ko) | 2011-09-06 | 2020-12-30 | 니코벤처스 트레이딩 리미티드 | 가열식 흡연가능 재료 |
| KR101752639B1 (ko) | 2011-09-06 | 2017-06-30 | 브리티시 아메리칸 토바코 (인베스트먼츠) 리미티드 | 가열식 끽연 가능 물질 |
| AT511344B1 (de) | 2011-10-21 | 2012-11-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| US8901177B2 (en) * | 2012-03-23 | 2014-12-02 | Targacept, Inc. | Method of treating bladder disorders |
| GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
| GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| GB2504075A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| GB2513639A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB2513637A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB2514893B (en) | 2013-06-04 | 2017-12-06 | Nicoventures Holdings Ltd | Container |
| GB201407426D0 (en) | 2014-04-28 | 2014-06-11 | Batmark Ltd | Aerosol forming component |
| GB2528673B (en) | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
| EP3182967B1 (en) * | 2014-08-22 | 2021-05-26 | Atacama Therapeutics, Inc. | Dexmecamylamine for use in the treatment of hyperhidrosis |
| GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 薬剤送達方法及びシステム |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| GB201505597D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
| GB201505595D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Cartridge for use with apparatus for heating smokeable material |
| GB201511361D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
| US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
| GB2542838B (en) | 2015-10-01 | 2022-01-12 | Nicoventures Trading Ltd | Aerosol provision system |
| US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
| WO2017187148A1 (en) | 2016-04-27 | 2017-11-02 | Nicoventures Holdings Limited | Electronic aerosol provision system and vaporizer therefor |
| EP3565617A1 (en) | 2017-01-06 | 2019-11-13 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| EP3801732A4 (en) | 2018-05-29 | 2022-04-27 | Morningside Venture Investments Limited | METHODS AND SYSTEMS FOR DRUG DELIVERY |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| GB202203728D0 (en) * | 2022-03-17 | 2022-05-04 | Univ Oxford Innovation Ltd | Treatments and methods for increasing dopamine |
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| US5039801A (en) * | 1985-12-20 | 1991-08-13 | The United States Of America As Represented By The Department Of Health & Human Services | Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines |
| US4749686A (en) * | 1986-12-04 | 1988-06-07 | New York Medical College | Combinations of renal vasodilators and α1 -adrenergic or ganglionic blocking agents and methods for treating diseases |
| DE3887591T2 (de) * | 1987-07-07 | 1994-05-19 | Beecham Group Plc | Pinacidil zur Behandlung von pulmonaler Hypertonie oder Rechtsversagen. |
| US5691365A (en) * | 1995-07-18 | 1997-11-25 | University Of Kentucky Research Foundation | Nicotinic receptor antagonists in the treatment of neuropharmacological disorders |
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- 1999-12-16 JP JP2000587609A patent/JP2002532393A/ja not_active Withdrawn
- 1999-12-16 AT AT99967401T patent/ATE320711T1/de active
- 1999-12-16 PT PT05024899T patent/PT1634498E/pt unknown
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- 1999-12-16 PT PT99967401T patent/PT1139743E/pt unknown
- 1999-12-16 WO PCT/US1999/030153 patent/WO2000035279A1/en not_active Ceased
- 1999-12-16 CA CA002393442A patent/CA2393442A1/en not_active Abandoned
- 1999-12-16 DE DE69939498T patent/DE69939498D1/de not_active Expired - Lifetime
- 1999-12-16 EP EP99967396A patent/EP1139744A4/en not_active Withdrawn
- 1999-12-16 AU AU23682/00A patent/AU2368200A/en not_active Abandoned
- 1999-12-16 DE DE69930552T patent/DE69930552T2/de not_active Expired - Lifetime
- 1999-12-16 EP EP05024899A patent/EP1634498B1/en not_active Expired - Lifetime
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- 1999-12-16 AT AT05024899T patent/ATE406797T1/de active
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2001
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2008
- 2008-11-19 CY CY20081101333T patent/CY1108577T1/el unknown
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2011
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2013
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2016
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Also Published As
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|---|---|
| JP2002532393A (ja) | 2002-10-02 |
| JP2014051528A (ja) | 2014-03-20 |
| PT1634498E (pt) | 2008-10-28 |
| DE69930552T2 (de) | 2006-11-30 |
| CY1108577T1 (el) | 2014-04-09 |
| ES2260959T3 (es) | 2006-11-01 |
| JP2016065108A (ja) | 2016-04-28 |
| US20020016370A1 (en) | 2002-02-07 |
| ES2313187T3 (es) | 2009-03-01 |
| EP1139743B1 (en) | 2006-03-22 |
| EP1139744A1 (en) | 2001-10-10 |
| CA2393437A1 (en) | 2000-06-22 |
| ATE406797T1 (de) | 2008-09-15 |
| DE69939498D1 (de) | 2008-10-16 |
| EP1634498B1 (en) | 2008-09-03 |
| JP2002532392A (ja) | 2002-10-02 |
| EP1139743A4 (en) | 2003-01-02 |
| EP1139744A4 (en) | 2003-01-02 |
| DK1634498T3 (da) | 2008-12-15 |
| AU2368600A (en) | 2000-07-03 |
| AU2368200A (en) | 2000-07-03 |
| CA2393442A1 (en) | 2000-06-22 |
| JP2011126909A (ja) | 2011-06-30 |
| ATE320711T1 (de) | 2006-04-15 |
| EP1139743A1 (en) | 2001-10-10 |
| EP1634498A3 (en) | 2006-03-29 |
| DE69930552D1 (de) | 2006-05-11 |
| WO2000035279A1 (en) | 2000-06-22 |
| PT1139743E (pt) | 2006-06-30 |
| EP1634498A2 (en) | 2006-03-15 |
| WO2000035280A1 (en) | 2000-06-22 |
| DK1139743T3 (da) | 2006-07-31 |
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