CA2384977A1 - Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods - Google Patents

Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods Download PDF

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Publication number
CA2384977A1
CA2384977A1 CA002384977A CA2384977A CA2384977A1 CA 2384977 A1 CA2384977 A1 CA 2384977A1 CA 002384977 A CA002384977 A CA 002384977A CA 2384977 A CA2384977 A CA 2384977A CA 2384977 A1 CA2384977 A1 CA 2384977A1
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CA
Canada
Prior art keywords
resonant optical
optical cavity
cavity
biosensor
cylindrical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002384977A
Other languages
English (en)
French (fr)
Inventor
Steven M. Blair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2384977A1 publication Critical patent/CA2384977A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/7746—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the waveguide coupled to a cavity resonator

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Plasma & Fusion (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
CA002384977A 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods Abandoned CA2384977A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15936699P 1999-10-14 1999-10-14
US60/159,366 1999-10-14
PCT/US2000/041138 WO2001040757A2 (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods

Publications (1)

Publication Number Publication Date
CA2384977A1 true CA2384977A1 (en) 2001-06-07

Family

ID=22572303

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002384977A Abandoned CA2384977A1 (en) 1999-10-14 2000-10-12 Resonant optical cavities for high-sensitivity, high-throughput biological sensors and methods

Country Status (5)

Country Link
EP (1) EP1221051A4 (ja)
JP (1) JP2003515737A (ja)
AU (1) AU4503201A (ja)
CA (1) CA2384977A1 (ja)
WO (1) WO2001040757A2 (ja)

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CN115078320A (zh) * 2022-05-17 2022-09-20 南京邮电大学 一种降低微腔核酸探测极限的方法及探测装置

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US7283707B1 (en) 2001-07-25 2007-10-16 Oewaves, Inc. Evanescently coupling light between waveguides and whispering-gallery mode optical resonators
US6853479B1 (en) 2001-08-30 2005-02-08 Oewaves, Inc. Apparatus and method for coupling light between an optical resonator and a semiconductor chip with a minimum number of components and alignment steps
US7399445B2 (en) 2002-01-11 2008-07-15 Canon Kabushiki Kaisha Chemical sensor
US6879752B1 (en) 2002-04-03 2005-04-12 Oewaves, Inc. Film spacer for setting the gap between an optical coupler and a whispering-gallery mode optical resonator
US20040184711A1 (en) 2002-06-20 2004-09-23 Kenneth Bradley Optical switches and routers and optical filters
US7781217B2 (en) * 2002-10-02 2010-08-24 California Institute Of Technology Biological and chemical microcavity resonant sensors and methods of detecting molecules
EP1550188B1 (en) 2002-10-11 2009-04-01 Canon Kabushiki Kaisha Sensor
US20050070027A1 (en) 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
US7444045B2 (en) 2003-10-14 2008-10-28 3M Innovative Properties Company Hybrid sphere-waveguide resonators
US7259855B2 (en) 2003-10-14 2007-08-21 3M Innovative Properties Company Porous microsphere resonators
AU2005248419C1 (en) * 2004-05-26 2011-03-10 Genera Biosystems Limited Biosensor using whispering gallery modes in microspheres
MXPA06013728A (es) * 2004-05-26 2007-05-09 Genera Biosystems Pty Ltd Biosensor que usa modos por galeria de murmullos en microesferas.
US7352933B2 (en) * 2004-05-27 2008-04-01 3M Innovative Properties Company Dielectric microcavity sensors
US7271379B2 (en) * 2004-05-27 2007-09-18 3M Innovative Properties Company Dielectric microcavity fluorosensors excited with a broadband light source
US7257279B2 (en) 2004-09-20 2007-08-14 3M Innovative Properties Company Systems and methods for biosensing and microresonator sensors for same
JP4565061B2 (ja) * 2004-10-06 2010-10-20 地方独立行政法人山口県産業技術センター 光分岐回路及びセンサ
JP2007047051A (ja) * 2005-08-10 2007-02-22 Nippon Telegr & Teleph Corp <Ntt> 多層屈折率測定装置
US7389025B2 (en) 2006-03-29 2008-06-17 3M Innovative Properties Company Coupling light into microresonators
US7532790B2 (en) 2006-03-29 2009-05-12 3M Innovative Properties Company Method of coupling light into microresonators
US7903240B2 (en) 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing device
US7486855B2 (en) 2006-12-27 2009-02-03 3M Innovative Properties Company Optical microresonator
US7702202B2 (en) 2006-12-01 2010-04-20 3M Innovative Properties Company Optical microresonator
US7933022B2 (en) 2006-12-01 2011-04-26 3M Innovative Properties Company Integrated optical disk resonator
US7903906B2 (en) 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing devices and methods
US7512298B2 (en) 2006-12-01 2009-03-31 3M Innovative Properties Company Optical sensing methods
US7778499B2 (en) * 2007-05-21 2010-08-17 National Research Council Of Canada Silicon photonic wire waveguide biosensor
US7796262B1 (en) 2007-05-31 2010-09-14 Nomadics, Inc. Integrated optical resonator device for measuring chemical and biological analyte concentrations
JP5424229B2 (ja) * 2007-09-28 2014-02-26 独立行政法人産業技術総合研究所 酸化膜を用いた光導波モードセンサー及びその製造方法
US8107081B2 (en) 2007-10-01 2012-01-31 California Institute Of Technology Micro-cavity gas and vapor sensors and detection methods
CN101849177B (zh) 2007-11-06 2012-07-04 Nxp股份有限公司 检测生物微粒的生物传感器设备和方法
US8092855B2 (en) 2007-11-28 2012-01-10 California Institute Of Technology Click chemistry surface functionalization for resonant micro-cavity sensors
WO2009084721A1 (en) * 2007-12-31 2009-07-09 Fujirebio Inc. Clusters of microresonators for cavity mode optical sensing
US8593638B2 (en) 2008-10-02 2013-11-26 California Institute Of Technology Split frequency sensing methods and systems
WO2010053209A1 (en) * 2008-11-05 2010-05-14 Fujirebio Inc. Method for sensing a biochemical and/or biomechanical process of a biological material and method for analyzing biological materials
US8368899B2 (en) * 2009-08-18 2013-02-05 Ofs Fitel, Llc Coiled evanescent optical sensor
WO2013080432A1 (ja) * 2011-11-28 2013-06-06 ソニー株式会社 ケミカルセンサ、ケミカルセンサモジュール、化学物質検出装置及び化学物質検出方法
CN102841054B (zh) * 2012-09-27 2015-07-29 复旦大学 一种耦合微腔光子分子的生物化学传感器
CN107014777B (zh) * 2017-03-30 2019-12-03 电子科技大学 聚合物微盘与液体微腔级联的高灵敏度生化传感器
CN110763654B (zh) * 2019-11-29 2023-03-17 江西师范大学 一种倾斜型高品质光学传感器及其制备方法

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115078320A (zh) * 2022-05-17 2022-09-20 南京邮电大学 一种降低微腔核酸探测极限的方法及探测装置

Also Published As

Publication number Publication date
WO2001040757A2 (en) 2001-06-07
JP2003515737A (ja) 2003-05-07
WO2001040757A3 (en) 2002-03-14
EP1221051A2 (en) 2002-07-10
AU4503201A (en) 2001-06-12
EP1221051A4 (en) 2003-03-05

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