CA2383224C - Extracts of orange peel for prevention and treatment of cancer - Google Patents

Extracts of orange peel for prevention and treatment of cancer Download PDF

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Publication number
CA2383224C
CA2383224C CA2383224A CA2383224A CA2383224C CA 2383224 C CA2383224 C CA 2383224C CA 2383224 A CA2383224 A CA 2383224A CA 2383224 A CA2383224 A CA 2383224A CA 2383224 C CA2383224 C CA 2383224C
Authority
CA
Canada
Prior art keywords
extract
orange peel
methoxyflavone
hydroxy
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2383224A
Other languages
English (en)
French (fr)
Other versions
CA2383224A1 (en
Inventor
Geetha Ghai
Robert T. Rosen
Chi-Tang Ho
Kuang Yu Chen
Nitin Telang
Martin Lipkin
Mou Tuan Huang
Charles Boyd
Katalin Csiszar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of CA2383224A1 publication Critical patent/CA2383224A1/en
Application granted granted Critical
Publication of CA2383224C publication Critical patent/CA2383224C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2383224A 1999-09-21 2000-09-20 Extracts of orange peel for prevention and treatment of cancer Expired - Fee Related CA2383224C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15501899P 1999-09-21 1999-09-21
US60/155,018 1999-09-21
PCT/US2000/025733 WO2001021137A1 (en) 1999-09-21 2000-09-20 Extracts of orange peel for prevention and treatment of cancer

Publications (2)

Publication Number Publication Date
CA2383224A1 CA2383224A1 (en) 2001-03-29
CA2383224C true CA2383224C (en) 2010-12-07

Family

ID=22553801

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2383224A Expired - Fee Related CA2383224C (en) 1999-09-21 2000-09-20 Extracts of orange peel for prevention and treatment of cancer

Country Status (5)

Country Link
EP (1) EP1214040A4 (ja)
JP (1) JP2003509447A (ja)
AU (1) AU7384900A (ja)
CA (1) CA2383224C (ja)
WO (1) WO2001021137A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100833805B1 (ko) * 2000-04-19 2008-05-30 니치유 가부시키가이샤 화장품 조성물
US20020146472A1 (en) 2000-11-15 2002-10-10 Chen Kuang Yu Black tea extract for prevention of disease
US7087790B2 (en) 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response
US7351739B2 (en) 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
US20070042972A1 (en) * 2005-05-24 2007-02-22 Mckeever Kenneth H Compositions and methods for optimizing exercise recovery
WO2007135569A2 (en) * 2006-02-09 2007-11-29 Kgk Synergize Inc Methods of treating canine osteosarcoma
WO2008035208A2 (en) * 2006-05-19 2008-03-27 Kgk Synergize Inc The use of flavonoids for the inhibition of cellular growth
CN100422168C (zh) * 2006-06-15 2008-10-01 中国科学技术大学 橙皮素衍生物及其制备方法
DE102007037772A1 (de) * 2007-08-10 2009-02-12 Csabai, Zsolt, Dr. Ph. Antioxidantenkomplex auf Grape Vital Basis (Citrus- und/oder Traubenkern und/oder Flavonoidbasis)
JP5742050B2 (ja) * 2011-03-01 2015-07-01 国立研究開発法人農業・食品産業技術総合研究機構 Ｎｋ細胞活性化剤、及びｎｋ細胞活性化方法
WO2013172682A1 (ko) 2012-05-16 2013-11-21 연세대학교 산학협력단 플라본계 화합물의 비만 예방 또는 치료용도
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
EP4218819A3 (en) * 2015-12-07 2023-08-23 Kyoto University Combination therapy based on pd-1 signal inhibitors
CN115772145A (zh) * 2022-11-29 2023-03-10 三峡大学 一种柑橘属果实提取物及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU703958B2 (en) * 1995-05-05 1999-04-01 Hauser Inc. High purity carnosic acid from rosemary and sage extracts by PH-controlled precipitation
JPH09176009A (ja) * 1995-12-27 1997-07-08 Inahata Koryo Kk 新規な抗変異原剤及び抗変異原性作用物質
US5830738A (en) * 1996-06-04 1998-11-03 Clemson University Extraction of pigment from plant material
US6251400B1 (en) * 1997-09-26 2001-06-26 Kgk Synergize Inc Compositions and methods of treatment of neoplastic diseases and hypercholesterolemia with citrus limonoids and flavonoids and tocotrienols
JP3571899B2 (ja) * 1997-12-18 2004-09-29 小川香料株式会社 香味劣化抑制剤

Also Published As

Publication number Publication date
CA2383224A1 (en) 2001-03-29
EP1214040A1 (en) 2002-06-19
WO2001021137A1 (en) 2001-03-29
JP2003509447A (ja) 2003-03-11
EP1214040A4 (en) 2004-06-23
WO2001021137A8 (en) 2001-07-26
AU7384900A (en) 2001-04-24

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Effective date: 20140922