CA2377498A1 - Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase - Google Patents

Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase Download PDF

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Publication number
CA2377498A1
CA2377498A1 CA002377498A CA2377498A CA2377498A1 CA 2377498 A1 CA2377498 A1 CA 2377498A1 CA 002377498 A CA002377498 A CA 002377498A CA 2377498 A CA2377498 A CA 2377498A CA 2377498 A1 CA2377498 A1 CA 2377498A1
Authority
CA
Canada
Prior art keywords
leu
seq
nucleic acid
arg
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002377498A
Other languages
English (en)
French (fr)
Inventor
Iris Pecker
Israel Michal
Hanan Itzhaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Strategy and Marketing Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2377498A1 publication Critical patent/CA2377498A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA002377498A 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase Abandoned CA2377498A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14080199P 1999-06-25 1999-06-25
US60/140,801 1999-06-25
PCT/IL2000/000358 WO2001000643A2 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Publications (1)

Publication Number Publication Date
CA2377498A1 true CA2377498A1 (en) 2001-01-04

Family

ID=22492846

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377498A Abandoned CA2377498A1 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Country Status (12)

Country Link
EP (1) EP1212341A4 (es)
JP (1) JP2003503070A (es)
KR (1) KR20020028906A (es)
CN (1) CN1370178A (es)
AU (1) AU777343B2 (es)
CA (1) CA2377498A1 (es)
HU (1) HUP0300901A2 (es)
IL (1) IL146527A0 (es)
MX (1) MXPA01011708A (es)
NO (1) NO20015526L (es)
PL (1) PL362599A1 (es)
WO (1) WO2001000643A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000052178A1 (en) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
CA2387695A1 (en) * 1999-09-23 2001-03-29 Klaus Ducker A novel member of the heparanase protein family
CA2393855A1 (en) * 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Homologues of human heparanase and splice variants thereof
AU3013901A (en) * 1999-12-23 2001-07-09 Schering Aktiengesellschaft Human heparanase-related polypeptide and nucleic acid
GB0014447D0 (en) * 2000-06-13 2000-08-09 Smithkline Beecham Plc Novel compounds
AU2001287610A1 (en) * 2000-07-12 2002-01-21 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
FI20085308A0 (fi) * 2008-04-11 2008-04-11 Polysackaridforskning I Uppsal Heparanaasittomia ihmiskuntaan kuulumattomia nisäkkäitä
JP5622451B2 (ja) * 2010-06-21 2014-11-12 小川香料株式会社 茶エキス
JP6321506B2 (ja) * 2014-09-22 2018-05-09 株式会社 資生堂 ヘパラナーゼ阻害剤による美白方法及び美白効果を有する物質の評価方法
JP6988481B2 (ja) * 2016-01-26 2022-01-05 日産化学株式会社 一本鎖オリゴヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
WO1999021975A1 (en) * 1997-10-28 1999-05-06 The Australian National University Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor

Also Published As

Publication number Publication date
AU777343B2 (en) 2004-10-14
WO2001000643A3 (en) 2005-02-24
MXPA01011708A (es) 2003-09-10
HUP0300901A2 (hu) 2003-07-28
PL362599A1 (en) 2004-11-02
KR20020028906A (ko) 2002-04-17
EP1212341A4 (en) 2002-11-27
IL146527A0 (en) 2002-07-25
WO2001000643A2 (en) 2001-01-04
CN1370178A (zh) 2002-09-18
NO20015526L (no) 2001-12-18
AU5244800A (en) 2001-01-31
EP1212341A1 (en) 2002-06-12
NO20015526D0 (no) 2001-11-12
JP2003503070A (ja) 2003-01-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued