HUP0300901A2 - Polinukleotidok és az általuk kódolt, heparanázzal távoli homológ polipeptidek - Google Patents
Polinukleotidok és az általuk kódolt, heparanázzal távoli homológ polipeptidekInfo
- Publication number
- HUP0300901A2 HUP0300901A2 HU0300901A HUP0300901A HUP0300901A2 HU P0300901 A2 HUP0300901 A2 HU P0300901A2 HU 0300901 A HU0300901 A HU 0300901A HU P0300901 A HUP0300901 A HU P0300901A HU P0300901 A2 HUP0300901 A2 HU P0300901A2
- Authority
- HU
- Hungary
- Prior art keywords
- polynucleotides
- heparanase
- polypeptides encoded
- recombinant proteins
- distantly homologous
- Prior art date
Links
- 108091033319 polynucleotide Proteins 0.000 title abstract 4
- 102000040430 polynucleotide Human genes 0.000 title abstract 4
- 239000002157 polynucleotide Substances 0.000 title abstract 4
- 102100024025 Heparanase Human genes 0.000 title abstract 3
- 108010037536 heparanase Proteins 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 2
- 102000053642 Catalytic RNA Human genes 0.000 abstract 1
- 108090000994 Catalytic RNA Proteins 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003147 glycosyl group Chemical group 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 108091092562 ribozyme Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány heparanázzal távoli homológ polipeptideket kódolópolinukleotidokra, a polinukleotidokat tartalmazó nukleinsav-szerkezetekre, ezeket kifejező genetikailag módosított sejtekre és azáltaluk kódolt rekombináns fehérjékre vonatkozik, mely fehérjékheparanáz vagy más glikozil-hidroláz aktivitással rendelkezhetnek. Atalálmány további tárgyát képezik a rekombináns fehérjéket felismerőantitestek, a polinukleotidokból származó oligonukleotidok ésoligonukleotidanalógok és az ezeket tartalmazó ribozimok. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14080199P | 1999-06-25 | 1999-06-25 | |
PCT/IL2000/000358 WO2001000643A2 (en) | 1999-06-25 | 2000-06-19 | Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0300901A2 true HUP0300901A2 (hu) | 2003-07-28 |
Family
ID=22492846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300901A HUP0300901A2 (hu) | 1999-06-25 | 2000-06-19 | Polinukleotidok és az általuk kódolt, heparanázzal távoli homológ polipeptidek |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1212341A4 (hu) |
JP (1) | JP2003503070A (hu) |
KR (1) | KR20020028906A (hu) |
CN (1) | CN1370178A (hu) |
AU (1) | AU777343B2 (hu) |
CA (1) | CA2377498A1 (hu) |
HU (1) | HUP0300901A2 (hu) |
IL (1) | IL146527A0 (hu) |
MX (1) | MXPA01011708A (hu) |
NO (1) | NO20015526L (hu) |
PL (1) | PL362599A1 (hu) |
WO (1) | WO2001000643A2 (hu) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000052178A1 (en) * | 1999-03-01 | 2000-09-08 | Insight Strategy & Marketing Ltd. | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells |
JP2003510053A (ja) * | 1999-09-23 | 2003-03-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ヘパラナーゼ蛋白質ファミリーの1種、ヘパラナーゼ−2 |
DK1240313T3 (da) * | 1999-12-22 | 2006-11-27 | Ucb Sa | Enzymer, som er homologe med heparanase og splejsningsvarianter deraf |
US20040161745A1 (en) * | 1999-12-23 | 2004-08-19 | Gerhard Siemeister | Human heparanase-related polypeptide and nucleic acid |
GB0014447D0 (en) * | 2000-06-13 | 2000-08-09 | Smithkline Beecham Plc | Novel compounds |
WO2002004645A2 (en) * | 2000-07-12 | 2002-01-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas |
IL162276A0 (en) * | 2004-06-01 | 2005-11-20 | Hadasit Med Res Service | Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof |
FI20085308A0 (fi) * | 2008-04-11 | 2008-04-11 | Polysackaridforskning I Uppsal | Heparanaasittomia ihmiskuntaan kuulumattomia nisäkkäitä |
JP5622451B2 (ja) * | 2010-06-21 | 2014-11-12 | 小川香料株式会社 | 茶エキス |
JP6321506B2 (ja) * | 2014-09-22 | 2018-05-09 | 株式会社 資生堂 | ヘパラナーゼ阻害剤による美白方法及び美白効果を有する物質の評価方法 |
AU2017211461B2 (en) * | 2016-01-26 | 2023-01-12 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US6242238B1 (en) * | 1997-10-28 | 2001-06-05 | The Australian National University | Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor |
-
2000
- 2000-06-19 CN CN00809505A patent/CN1370178A/zh active Pending
- 2000-06-19 PL PL00362599A patent/PL362599A1/xx unknown
- 2000-06-19 WO PCT/IL2000/000358 patent/WO2001000643A2/en not_active Application Discontinuation
- 2000-06-19 AU AU52448/00A patent/AU777343B2/en not_active Ceased
- 2000-06-19 IL IL14652700A patent/IL146527A0/xx unknown
- 2000-06-19 CA CA002377498A patent/CA2377498A1/en not_active Abandoned
- 2000-06-19 EP EP00937164A patent/EP1212341A4/en not_active Withdrawn
- 2000-06-19 KR KR1020017016406A patent/KR20020028906A/ko not_active Application Discontinuation
- 2000-06-19 JP JP2001507050A patent/JP2003503070A/ja active Pending
- 2000-06-19 MX MXPA01011708A patent/MXPA01011708A/es not_active Application Discontinuation
- 2000-06-19 HU HU0300901A patent/HUP0300901A2/hu unknown
-
2001
- 2001-11-12 NO NO20015526A patent/NO20015526L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2003503070A (ja) | 2003-01-28 |
NO20015526L (no) | 2001-12-18 |
PL362599A1 (en) | 2004-11-02 |
WO2001000643A2 (en) | 2001-01-04 |
KR20020028906A (ko) | 2002-04-17 |
EP1212341A1 (en) | 2002-06-12 |
MXPA01011708A (es) | 2003-09-10 |
IL146527A0 (en) | 2002-07-25 |
AU5244800A (en) | 2001-01-31 |
CA2377498A1 (en) | 2001-01-04 |
EP1212341A4 (en) | 2002-11-27 |
CN1370178A (zh) | 2002-09-18 |
WO2001000643A3 (en) | 2005-02-24 |
AU777343B2 (en) | 2004-10-14 |
NO20015526D0 (no) | 2001-11-12 |
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