CA2373045C - Gene therapy using tgf-.beta. - Google Patents

Gene therapy using tgf-.beta. Download PDF

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Publication number
CA2373045C
CA2373045C CA2373045A CA2373045A CA2373045C CA 2373045 C CA2373045 C CA 2373045C CA 2373045 A CA2373045 A CA 2373045A CA 2373045 A CA2373045 A CA 2373045A CA 2373045 C CA2373045 C CA 2373045C
Authority
CA
Canada
Prior art keywords
tgf
cells
cartilage
connective tissue
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2373045A
Other languages
English (en)
French (fr)
Other versions
CA2373045A1 (en
Inventor
Moon Jong Noh
Kyoung Ae Kang
Kwan Hee Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kolon TissueGene Inc
Original Assignee
TissueGene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019990015854A external-priority patent/KR20000072904A/ko
Priority claimed from US09/345,415 external-priority patent/US6315992B1/en
Application filed by TissueGene Inc filed Critical TissueGene Inc
Publication of CA2373045A1 publication Critical patent/CA2373045A1/en
Application granted granted Critical
Publication of CA2373045C publication Critical patent/CA2373045C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2373045A 1999-05-03 2000-05-03 Gene therapy using tgf-.beta. Expired - Lifetime CA2373045C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1999/15854 1999-05-03
KR1019990015854A KR20000072904A (ko) 1999-05-03 1999-05-03 ＴＧＦ-β분비세포를 포함하는 인대손상 치료 및 연골재생 촉진제
US09/345,415 US6315992B1 (en) 1999-06-30 1999-06-30 Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1
US09/345,415 1999-06-30
WOPCT/US00/00653 2000-05-03
PCT/IB2000/000653 WO2000066177A1 (en) 1999-05-03 2000-05-03 GENE THERAPY USING TGF-$g(b)

Publications (2)

Publication Number Publication Date
CA2373045A1 CA2373045A1 (en) 2000-11-09
CA2373045C true CA2373045C (en) 2016-07-26

Family

ID=26635050

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2373045A Expired - Lifetime CA2373045C (en) 1999-05-03 2000-05-03 Gene therapy using tgf-.beta.

Country Status (7)

Country Link
EP (1) EP1175228A4 (zh)
JP (3) JP4592186B2 (zh)
KR (1) KR100702725B1 (zh)
CN (2) CN1371289B (zh)
AU (1) AU778047B2 (zh)
CA (1) CA2373045C (zh)
WO (1) WO2000066177A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002243307A1 (en) * 2000-11-08 2002-07-24 Tissuegene, Inc. Gene therapy using tgf-beta
US20030175257A1 (en) * 2002-03-12 2003-09-18 Song Sun Uk Cartilage regeneration using chondrocyte and TGF-beta
US7005127B2 (en) * 2002-03-29 2006-02-28 Tissuegene, Inc. Mixed-cell gene therapy
AU2003251854A1 (en) * 2002-07-09 2004-01-23 Stryker Corporation Compositions and methods for ligament growth and repair
CN100394989C (zh) * 2002-11-15 2008-06-18 华沙整形外科股份有限公司 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
WO2005073365A1 (ja) * 2004-01-29 2005-08-11 Japan Tissue Engineering Co., Ltd. 移植用細胞の処理方法、細胞懸濁液、移植用補綴物、および損傷部位の治療方法
JP6125751B2 (ja) * 2008-03-21 2017-05-10 ティシュージーン，インク． 椎間板変性症の治療
JP5388233B2 (ja) * 2011-01-19 2014-01-15 富士ソフト株式会社 再生軟骨の軟骨特性を評価する方法
US10793625B2 (en) * 2012-05-01 2020-10-06 The Johns Hopkins University Compositions and methods for treating or preventing osteoarthritis
WO2015035395A1 (en) * 2013-09-09 2015-03-12 Figene, Llc Gene therapy for the regeneration of chondrocytes or cartilage type cells
KR20190003414A (ko) * 2017-06-30 2019-01-09 코오롱생명과학 주식회사 세포치료제의 유효성 평가 방법
CN113372432A (zh) * 2021-06-15 2021-09-10 深圳市臻质医疗科技有限公司 一种基于化学修饰mRNA编码蛋白因子诱导和/或增强软骨损伤修复的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413511B1 (en) * 1990-12-20 2002-07-02 University Of Pittsburgh Of The Commonwealth System Of Higher Education Cartilage alterations by administering to joints chondrocytes comprising a heterologous polynucleotide
US5858355A (en) * 1990-12-20 1999-01-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education IRAP gene as treatment for arthritis
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
DK2075002T3 (da) * 1998-05-01 2013-05-21 Univ Pittsburgh Myoblaster til reparation af urinvejslukkemuskel
US6315992B1 (en) * 1999-06-30 2001-11-13 Tissuegene Co. Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1

Also Published As

Publication number Publication date
CA2373045A1 (en) 2000-11-09
WO2000066177A1 (en) 2000-11-09
KR100702725B1 (ko) 2007-04-03
CN1371289A (zh) 2002-09-25
EP1175228A1 (en) 2002-01-30
EP1175228A4 (en) 2003-02-26
KR20020036943A (ko) 2002-05-17
JP2002542801A (ja) 2002-12-17
JP2009019039A (ja) 2009-01-29
JP4547446B2 (ja) 2010-09-22
JP4188986B2 (ja) 2008-12-03
JP2007008950A (ja) 2007-01-18
JP4592186B2 (ja) 2010-12-01
AU778047B2 (en) 2004-11-11
CN101972275A (zh) 2011-02-16
CN1371289B (zh) 2013-03-20
AU4424200A (en) 2000-11-17

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US6315992B1 (en) Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1
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Effective date: 20200503