CA2370659A1 - Recepteur p2x3, methodes destinees a modifier l'activite d'un recepteur p2x3 et leurs utilisations - Google Patents

Recepteur p2x3, methodes destinees a modifier l'activite d'un recepteur p2x3 et leurs utilisations Download PDF

Info

Publication number
CA2370659A1
CA2370659A1 CA002370659A CA2370659A CA2370659A1 CA 2370659 A1 CA2370659 A1 CA 2370659A1 CA 002370659 A CA002370659 A CA 002370659A CA 2370659 A CA2370659 A CA 2370659A CA 2370659 A1 CA2370659 A1 CA 2370659A1
Authority
CA
Canada
Prior art keywords
receptor
cell
human
polynucleotide
atp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002370659A
Other languages
English (en)
Inventor
Michael F. Jarvis
Kevin J. Lynch
Edward C. Burgard
Timothy Van Biesen
Elizabeth A. Kowaluk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2370659A1 publication Critical patent/CA2370659A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un récepteur P2X¿3?, des méthodes destinées à moduler l'activité du récepteur P2X¿3? et les utilisations de ces méthodes. Ces méthodes peuvent, par exemple, être utilisées pour accélérer la resensibilisation d'un récepteur désensibilisé.
CA002370659A 1999-04-21 2000-04-21 Recepteur p2x3, methodes destinees a modifier l'activite d'un recepteur p2x3 et leurs utilisations Abandoned CA2370659A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13033999P 1999-04-21 1999-04-21
US60/130,339 1999-04-21
PCT/US2000/010919 WO2000063379A2 (fr) 1999-04-21 2000-04-21 Recepteur p2x3, methodes destinees a modifier l'activite d'un recepteur p2x3 et leurs utilisations

Publications (1)

Publication Number Publication Date
CA2370659A1 true CA2370659A1 (fr) 2000-10-26

Family

ID=22444222

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002370659A Abandoned CA2370659A1 (fr) 1999-04-21 2000-04-21 Recepteur p2x3, methodes destinees a modifier l'activite d'un recepteur p2x3 et leurs utilisations

Country Status (5)

Country Link
EP (1) EP1180141A2 (fr)
JP (1) JP2004500021A (fr)
CA (1) CA2370659A1 (fr)
MX (1) MXPA01010646A (fr)
WO (1) WO2000063379A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE537169T1 (de) 2005-08-15 2011-12-15 Hoffmann La Roche Piperidin- und piperazinderivate als p2x3- antagonisten
WO2007041087A2 (fr) * 2005-09-30 2007-04-12 Merck & Co., Inc. Acides nucleiques codant pour un recepteur purinergique fonctionnel de mammifere, p2x3, et leurs procedes de production et d'utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1045903A1 (fr) * 1998-01-16 2000-10-25 Abbott Laboratories Acides nucleiques codant un purinorecepteur fonctionnel humain p2x3 et procedes de production et d'utilisation de ces derniers

Also Published As

Publication number Publication date
WO2000063379A3 (fr) 2001-11-15
MXPA01010646A (es) 2002-05-06
EP1180141A2 (fr) 2002-02-20
JP2004500021A (ja) 2004-01-08
WO2000063379A2 (fr) 2000-10-26

Similar Documents

Publication Publication Date Title
Xu et al. Coassembly of TRP and TRPL produces a distinct store-operated conductance
Collo et al. Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
US6323000B2 (en) Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
US20020086298A1 (en) DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
Meadows et al. The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K+ channels TREK-1 and TRAAK
WO2007053526A1 (fr) Compositions et methodes permettant d'identifier les modulateurs de trpv2
US20100221773A1 (en) Nucleic Acids Encoding a Functional Mammalin Purinoreceptor, P2X3, Methods of Production and Use Thereof
US6242216B1 (en) Nucleic acids encoding a functional human purinoreceptor P2X2 and P2X4, and methods of production and use thereof
US6214581B1 (en) Nucleic acids encoding a functional human purinoreceptor P2X3 and P2X6, and methods of production and use thereof
CA2370659A1 (fr) Recepteur p2x3, methodes destinees a modifier l'activite d'un recepteur p2x3 et leurs utilisations
US7547521B2 (en) Heteromultimeric ion channel receptor and uses thereof
WO1999055901A2 (fr) Technique de criblage fonctionnel de grande capacite servant a identifier des ligands de purinorecepteurs humains
JP2004500021A5 (fr)
KR100851255B1 (ko) Ｇ 단백질 커플된 수용체
US6555341B1 (en) Human theta subunit of the GABAa receptor
CA2339871A1 (fr) Acides nucleiques codant un purinorecepteur fonctionnel humain p2x2, et procedes de production et d'utilisation de ce dernier
EP1045903A1 (fr) Acides nucleiques codant un purinorecepteur fonctionnel humain p2x3 et procedes de production et d'utilisation de ces derniers
US20050119458A1 (en) Novel human proton-gated channels
US7229779B2 (en) Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof
US20040115668A1 (en) Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3
US6635741B1 (en) G-protein coupled receptor BCA-GPCR-3
CA2432274A1 (fr) Hcn3 de canal cationique declenche par des nucleotides cycliques et actives par hyperpolarisation chez l'homme
MXPA01001855A (en) Nucleic acids encoding a functional human purinoreceptor p2x2
US20050014141A1 (en) Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn1
CA2453655A1 (fr) Nouveaux canaux a porte protonique humains

Legal Events

Date Code Title Description
FZDE Dead