CA2368228C - Method and system for ablating surfaces with partially overlapping craters having consistent curvature - Google Patents
Method and system for ablating surfaces with partially overlapping craters having consistent curvature Download PDFInfo
- Publication number
- CA2368228C CA2368228C CA2368228A CA2368228A CA2368228C CA 2368228 C CA2368228 C CA 2368228C CA 2368228 A CA2368228 A CA 2368228A CA 2368228 A CA2368228 A CA 2368228A CA 2368228 C CA2368228 C CA 2368228C
- Authority
- CA
- Canada
- Prior art keywords
- laser beam
- region
- laser
- energy
- pulsed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract description 52
- 238000002679 ablation Methods 0.000 claims abstract description 57
- 238000007493 shaping process Methods 0.000 claims abstract description 40
- 210000004087 cornea Anatomy 0.000 claims description 29
- 238000009826 distribution Methods 0.000 claims description 21
- 230000008859 change Effects 0.000 claims description 18
- 230000003287 optical effect Effects 0.000 claims description 18
- 238000003384 imaging method Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 4
- 239000011358 absorbing material Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 40
- 238000013459 approach Methods 0.000 description 12
- 238000011282 treatment Methods 0.000 description 10
- 230000036571 hydration Effects 0.000 description 5
- 238000006703 hydration reaction Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 210000005081 epithelial layer Anatomy 0.000 description 4
- 210000000981 epithelium Anatomy 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000000608 laser ablation Methods 0.000 description 3
- 238000013532 laser treatment Methods 0.000 description 3
- 208000014733 refractive error Diseases 0.000 description 3
- 230000004304 visual acuity Effects 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- ISQINHMJILFLAQ-UHFFFAOYSA-N argon hydrofluoride Chemical compound F.[Ar] ISQINHMJILFLAQ-UHFFFAOYSA-N 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010020675 Hypermetropia Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000006318 hyperopia Diseases 0.000 description 1
- 230000004305 hyperopia Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 201000010041 presbyopia Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- RIUWBIIVUYSTCN-UHFFFAOYSA-N trilithium borate Chemical compound [Li+].[Li+].[Li+].[O-]B([O-])[O-] RIUWBIIVUYSTCN-UHFFFAOYSA-N 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00804—Refractive treatments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20351—Scanning mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2035—Beam shaping or redirecting; Optical components therefor
- A61B2018/20351—Scanning mechanisms
- A61B2018/20355—Special scanning path or conditions, e.g. spiral, raster or providing spot overlap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2065—Multiwave; Wavelength mixing, e.g. using four or more wavelengths
- A61B2018/207—Multiwave; Wavelength mixing, e.g. using four or more wavelengths mixing two wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00844—Feedback systems
- A61F2009/00846—Eyetracking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00817—Beam shaping with masks
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Laser Surgery Devices (AREA)
- Mechanical Optical Scanning Systems (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Laser Beam Processing (AREA)
- Chemically Coating (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/303,810 US6497701B2 (en) | 1999-04-30 | 1999-04-30 | Method and system for ablating surfaces with partially overlapping craters having consistent curvature |
| US09/303,810 | 1999-04-30 | ||
| PCT/US2000/005276 WO2000066022A1 (en) | 1999-04-30 | 2000-02-28 | Method and system for ablating surfaces with partially overlapping craters having consistent curvature |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2368228A1 CA2368228A1 (en) | 2000-11-09 |
| CA2368228C true CA2368228C (en) | 2011-06-07 |
Family
ID=23173810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2368228A Expired - Lifetime CA2368228C (en) | 1999-04-30 | 2000-02-28 | Method and system for ablating surfaces with partially overlapping craters having consistent curvature |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6497701B2 (enExample) |
| EP (1) | EP1180981B1 (enExample) |
| JP (1) | JP4615735B2 (enExample) |
| AT (1) | ATE463218T1 (enExample) |
| AU (1) | AU3612300A (enExample) |
| CA (1) | CA2368228C (enExample) |
| DE (1) | DE60044126D1 (enExample) |
| MX (1) | MXPA01010867A (enExample) |
| WO (1) | WO2000066022A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4003918B2 (ja) * | 2000-10-20 | 2007-11-07 | 株式会社ニデック | 角膜手術装置 |
| US7918846B2 (en) * | 2000-12-05 | 2011-04-05 | Amo Manufacturing Usa, Llc | Method and system for laser treatment of refractive errors using offset imaging |
| US6740078B2 (en) * | 2001-04-24 | 2004-05-25 | Gustavo E. Tamayo | Method and apparatus for treating presbyopia |
| US7156859B2 (en) | 2001-07-23 | 2007-01-02 | Fos Holding S.A. | Device for separating the epithelium layer from the surface of the cornea of an eye |
| DE10164579C1 (de) * | 2001-12-28 | 2003-08-21 | Jenoptik Automatisierungstech | Verfahren zum Trennen von Lichtleitfasern mittels CO¶2¶-Laserstrahlung |
| EP1539013A4 (en) | 2002-06-19 | 2005-09-21 | Palomar Medical Tech Inc | METHOD AND DEVICE FOR TREATING SKIN AND SUB-TISSUE DISEASES |
| DE10307741A1 (de) * | 2003-02-24 | 2004-09-02 | Carl Zeiss Meditec Ag | Anordnung zur Bildfeldverbesserung bei ophthalmologischen Geräten |
| DE10332815B4 (de) * | 2003-07-18 | 2020-10-22 | Carl Zeiss Meditec Ag | Verfahren und Vorrichtung zum Ausbilden gekrümmter Schnittflächen in einem transparenten Material |
| DE10333770A1 (de) * | 2003-07-22 | 2005-02-17 | Carl Zeiss Meditec Ag | Verfahren zur Materialbearbeitung mit Laserimpulsen grosser spektraler Bandbreite und Vorrichtung zur Durchführung des Verfahrens |
| DE10334110A1 (de) * | 2003-07-25 | 2005-02-17 | Carl Zeiss Meditec Ag | Vorrichtung und Verfahren zum Ausbilden gekrümmter Schnittflächen in einem transparenten Material |
| DE10334108B4 (de) * | 2003-07-25 | 2018-05-09 | Carl Zeiss Meditec Ag | Vorrichtung zum Ausbilden einer geschlossenen, gekrümmten Schnittfläche |
| JP4729883B2 (ja) * | 2003-10-31 | 2011-07-20 | セイコーエプソン株式会社 | 基板の加工方法、マイクロレンズシートの製造方法、透過型スクリーン、プロジェクタ、表示装置並びに基板の加工装置 |
| DE102004014181A1 (de) | 2004-03-23 | 2005-10-06 | Carl Zeiss Meditec Ag | Material-Bearbeitungsvorrichtung und -verfahren |
| US7206132B2 (en) | 2004-08-06 | 2007-04-17 | Visx, Incorporated | Lenslet array for beam homogenization |
| US7252662B2 (en) * | 2004-11-02 | 2007-08-07 | Lenticular Research Group Llc | Apparatus and processes for preventing or delaying one or more symptoms of presbyopia |
| US8394084B2 (en) | 2005-01-10 | 2013-03-12 | Optimedica Corporation | Apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation |
| AU2016203089B2 (en) * | 2005-01-10 | 2017-04-06 | Amo Development, Llc | Method and apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation |
| EP1848389B1 (de) | 2005-02-15 | 2011-07-20 | Carl Zeiss Meditec AG | Verfahren zur herstellung eines ablationsprogramms, in abhängigkeit von der form eines laserstrahlprofils und von einer neigung der zu ablatierenden oberfläche ; mittel zur durchführung der verfahren |
| US9649224B2 (en) * | 2005-02-19 | 2017-05-16 | Lenticular Research Group Llc | Apparatus and processes for preventing or delaying onset or progression of age-related cataract |
| US7856985B2 (en) * | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
| US7413566B2 (en) * | 2005-05-19 | 2008-08-19 | Amo Manufacturing Usa, Llc | Training enhanced pseudo accommodation methods, systems and devices for mitigation of presbyopia |
| GB2439286B (en) * | 2006-06-22 | 2010-09-15 | Dezac Group Ltd | Apparatus and methods for skin treatment |
| US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
| CN101605504A (zh) | 2006-11-10 | 2009-12-16 | 眼科医疗公司 | 用于在眼科光医学中确定剂量测定的系统和方法 |
| EP2617397B1 (en) | 2007-03-13 | 2016-12-14 | Optimedica Corporation | Intraocular lens providing improved placement |
| JP2010538700A (ja) | 2007-09-06 | 2010-12-16 | アルコン レンゼックス, インコーポレーテッド | 外科的光破壊の精密な目標設定 |
| WO2009124021A2 (en) * | 2008-03-31 | 2009-10-08 | Lenticular Research Group, Llc | Processes and apparatus for preventing, delaying or ameliorating one or more symptoms of presbyopia |
| US9492322B2 (en) | 2009-11-16 | 2016-11-15 | Alcon Lensx, Inc. | Imaging surgical target tissue by nonlinear scanning |
| US8265364B2 (en) | 2010-02-05 | 2012-09-11 | Alcon Lensx, Inc. | Gradient search integrated with local imaging in laser surgical systems |
| US8414564B2 (en) | 2010-02-18 | 2013-04-09 | Alcon Lensx, Inc. | Optical coherence tomographic system for ophthalmic surgery |
| US8398236B2 (en) | 2010-06-14 | 2013-03-19 | Alcon Lensx, Inc. | Image-guided docking for ophthalmic surgical systems |
| US9532708B2 (en) | 2010-09-17 | 2017-01-03 | Alcon Lensx, Inc. | Electronically controlled fixation light for ophthalmic imaging systems |
| US20110147350A1 (en) * | 2010-12-03 | 2011-06-23 | Uvtech Systems Inc. | Modular apparatus for wafer edge processing |
| US8459794B2 (en) | 2011-05-02 | 2013-06-11 | Alcon Lensx, Inc. | Image-processor-controlled misalignment-reduction for ophthalmic systems |
| US9622913B2 (en) | 2011-05-18 | 2017-04-18 | Alcon Lensx, Inc. | Imaging-controlled laser surgical system |
| US8398238B1 (en) | 2011-08-26 | 2013-03-19 | Alcon Lensx, Inc. | Imaging-based guidance system for ophthalmic docking using a location-orientation analysis |
| JP5861329B2 (ja) * | 2011-08-31 | 2016-02-16 | 株式会社ニデック | 眼科用レーザ治療装置 |
| DE102011085047A1 (de) | 2011-10-21 | 2013-04-25 | Carl Zeiss Meditec Ag | Erzeugung von Schnitten in einem transparenten Material mittels optischer Strahlung |
| DE102011085046A1 (de) | 2011-10-21 | 2013-04-25 | Carl Zeiss Meditec Ag | Erzeugung von Schnittflächen in einem transparenten Material mittels optischer Strahlung |
| US9066784B2 (en) | 2011-12-19 | 2015-06-30 | Alcon Lensx, Inc. | Intra-surgical optical coherence tomographic imaging of cataract procedures |
| US9023016B2 (en) | 2011-12-19 | 2015-05-05 | Alcon Lensx, Inc. | Image processor for intra-surgical optical coherence tomographic imaging of laser cataract procedures |
| KR102183581B1 (ko) | 2012-04-18 | 2020-11-27 | 싸이노슈어, 엘엘씨 | 피코초 레이저 장치 및 그를 사용한 표적 조직의 치료 방법 |
| US10058453B2 (en) * | 2012-04-24 | 2018-08-28 | Wavelight Gmbh | Extracting lenticules for refractive correction |
| US9398979B2 (en) | 2013-03-11 | 2016-07-26 | Technolas Perfect Vision Gmbh | Dimensional compensator for use with a patient interface |
| EP2973894A2 (en) | 2013-03-15 | 2016-01-20 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
| EP3759770A4 (en) | 2018-02-26 | 2021-12-08 | Cynosure, LLC | Q-SWITCHED CAVITY DUMP SUBNANO CUSTOMER LASER |
| US10837828B2 (en) * | 2018-09-05 | 2020-11-17 | Government Of The United States Of America, As Represented By The Secretary Of Commerce | Non-attenuating meter for determining optical energy of laser light |
| US11484361B2 (en) * | 2019-08-27 | 2022-11-01 | Nikolai Tankovich | Tip for multiple beam tissue therapy |
| CN112719573A (zh) * | 2020-12-09 | 2021-04-30 | 成都宏明双新科技股份有限公司 | 一种高效提升产品镭雕效率的方法 |
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-
1999
- 1999-04-30 US US09/303,810 patent/US6497701B2/en not_active Expired - Lifetime
-
2000
- 2000-02-28 AU AU36123/00A patent/AU3612300A/en not_active Abandoned
- 2000-02-28 MX MXPA01010867A patent/MXPA01010867A/es active IP Right Grant
- 2000-02-28 DE DE60044126T patent/DE60044126D1/de not_active Expired - Lifetime
- 2000-02-28 EP EP00914778A patent/EP1180981B1/en not_active Expired - Lifetime
- 2000-02-28 JP JP2000614910A patent/JP4615735B2/ja not_active Expired - Lifetime
- 2000-02-28 WO PCT/US2000/005276 patent/WO2000066022A1/en not_active Ceased
- 2000-02-28 CA CA2368228A patent/CA2368228C/en not_active Expired - Lifetime
- 2000-02-28 AT AT00914778T patent/ATE463218T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1180981A4 (en) | 2005-09-28 |
| US20020151878A1 (en) | 2002-10-17 |
| MXPA01010867A (es) | 2002-05-06 |
| ATE463218T1 (de) | 2010-04-15 |
| EP1180981A1 (en) | 2002-02-27 |
| DE60044126D1 (de) | 2010-05-20 |
| US6497701B2 (en) | 2002-12-24 |
| JP2002542877A (ja) | 2002-12-17 |
| WO2000066022A9 (en) | 2001-12-27 |
| CA2368228A1 (en) | 2000-11-09 |
| AU3612300A (en) | 2000-11-17 |
| JP4615735B2 (ja) | 2011-01-19 |
| EP1180981B1 (en) | 2010-04-07 |
| WO2000066022A1 (en) | 2000-11-09 |
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