CA2367212A1 - Structure polypeptidique utilisable comme echafaudage - Google Patents

Structure polypeptidique utilisable comme echafaudage Download PDF

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Publication number
CA2367212A1
CA2367212A1 CA002367212A CA2367212A CA2367212A1 CA 2367212 A1 CA2367212 A1 CA 2367212A1 CA 002367212 A CA002367212 A CA 002367212A CA 2367212 A CA2367212 A CA 2367212A CA 2367212 A1 CA2367212 A1 CA 2367212A1
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CA
Canada
Prior art keywords
seq
amino acid
loops
sequence
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002367212A
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English (en)
Inventor
Johan Desmet
Simon Hufton
Hendricus Hoogenboom
Erwin Sablon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Innogenetics NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics NV SA filed Critical Innogenetics NV SA
Publication of CA2367212A1 publication Critical patent/CA2367212A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne une chaîne polypeptidique possédant une architecture sandwich .beta. qui peut être utilisée comme échafaudage, c'est à dire comme cadre de support, portant des fragments se liant à un antigène ou à un récepteur. Plus particulièrement, cette invention concerne un sandwich .beta. de type CTLA4 portant des séquences peptidiques nouvelles et randomisées.
CA002367212A 1999-04-01 1999-04-01 Structure polypeptidique utilisable comme echafaudage Abandoned CA2367212A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1999/002283 WO2000060070A1 (fr) 1999-04-01 1999-04-01 Structure polypeptidique utilisable comme echafaudage

Publications (1)

Publication Number Publication Date
CA2367212A1 true CA2367212A1 (fr) 2000-10-12

Family

ID=8167259

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002367212A Abandoned CA2367212A1 (fr) 1999-04-01 1999-04-01 Structure polypeptidique utilisable comme echafaudage

Country Status (4)

Country Link
EP (1) EP1163339A1 (fr)
AU (1) AU4499499A (fr)
CA (1) CA2367212A1 (fr)
WO (1) WO2000060070A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011415A (zh) * 2008-10-20 2017-08-04 光州科学技术院 双齿肽结合物

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EP1318195A1 (fr) * 2001-12-10 2003-06-11 CatchMabs B.V. Une structure pour la présentation des séquences de peptides désirées
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
WO2004022746A1 (fr) 2002-09-06 2004-03-18 Isogenica Limited Banque d'expression in vitro de peptides
US20050079546A1 (en) * 2003-05-01 2005-04-14 Dasa Lipovsek Serum albumin scaffold-based proteins and uses thereof
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
US7749694B2 (en) 2004-12-31 2010-07-06 The Regents Of The University Of California C-type lectin fold as a scaffold for massive sequence variation
US7700729B2 (en) 2006-05-15 2010-04-20 Avidbiotics Corporation Modified bacteriocins and methods for their use
JP5603070B2 (ja) 2006-05-15 2014-10-08 アビッドバイオティクス コーポレイション 改変バクテリオシン及びその使用方法
US8445639B2 (en) 2006-05-15 2013-05-21 Avidbiotics Corporation Recombinant bacteriophage and methods for their use
CA2679986C (fr) 2007-03-08 2018-03-06 Martin Lackmann Anticorps epha3 utilises dans le traitement des tumeurs solides
AU2010221159B2 (en) 2009-03-06 2015-11-26 Humanigen, Inc. Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3
AU2010326024A1 (en) 2009-12-02 2012-07-05 Amgen Inc. Binding proteins that bind to human FGFR1c, human beta-Klotho and both human FGFR1c and human beta-Klotho
CN109310766A (zh) * 2016-02-26 2019-02-05 伊蒙纽斯私人有限公司 多特异性分子
EP3433281A1 (fr) 2016-03-21 2019-01-30 Elstar Therapeutics, Inc. Molécules multispécifiques et multifonctionnelles et leurs utilisations
CA3020830A1 (fr) 2016-04-13 2017-10-19 Vivia Biotech, S.L Lymphocytes t actives ex vivo par bite.rtm.
WO2017210598A1 (fr) 2016-06-03 2017-12-07 Amgen Inc. Compositions et procédés de traitement d'un trouble articulaire
CN118005799A (zh) 2016-09-23 2024-05-10 马伦戈治疗公司 包含λ轻链和κ轻链的多特异性抗体分子
WO2018151820A1 (fr) 2017-02-16 2018-08-23 Elstar Therapeutics, Inc. Molécules multifonctionnelles comprenant un ligand trimérique et leurs utilisations
WO2018195283A1 (fr) 2017-04-19 2018-10-25 Elstar Therapeutics, Inc. Molécules multispécifiques et utilisations correspondantes
CA3059769A1 (fr) 2017-04-28 2018-11-01 Elstar Therapeutics, Inc. Molecules multispecifiques comprenant un domaine d'heterodimerisation non immunoglobuline et leurs utilisations
US20210246227A1 (en) 2017-05-31 2021-08-12 Elstar Therapeutics, Inc. Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
WO2019035938A1 (fr) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. Molécules multispécifiques se liant à bcma et leurs utilisations
WO2019113464A1 (fr) 2017-12-08 2019-06-13 Elstar Therapeutics, Inc. Molécules multispécifiques et utilisations correspondantes
WO2019178362A1 (fr) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Molécules multifonctionnelles se liant à calréticuline et utilisations associees
WO2019178364A2 (fr) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Molécules multifonctionnelles et utilisations associées
EP3818083A2 (fr) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Molécules d'anticorps anti-tcr et leurs utilisations
AU2019346645A1 (en) 2018-09-27 2021-04-29 Marengo Therapeutics, Inc. CSF1R/CCR2 multispecific antibodies
CN114127112A (zh) 2019-02-21 2022-03-01 马伦戈治疗公司 与t细胞结合的多功能分子及其治疗自身免疫性病症的用途
AU2020226904A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
CN114026122A (zh) 2019-02-21 2022-02-08 马伦戈治疗公司 结合t细胞相关癌细胞的多功能分子及其用途
JP2022521937A (ja) 2019-02-21 2022-04-13 マレンゴ・セラピューティクス，インコーポレーテッド ＮＫｐ３０に結合する抗体分子およびその使用
SG11202109056TA (en) 2019-02-21 2021-09-29 Marengo Therapeutics Inc Multifunctional molecules that bind to calreticulin and uses thereof
WO2021138407A2 (fr) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant à cd33 et utilisations associées
WO2021217085A1 (fr) 2020-04-24 2021-10-28 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant à des cellules cancéreuses associées à des lymphocytes t et leurs utilisations
EP4204458A1 (fr) 2020-08-26 2023-07-05 Marengo Therapeutics, Inc. Procédés de détection de trbc1 ou de trbc2
WO2022046920A2 (fr) 2020-08-26 2022-03-03 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant à la calréticuline et utilisations associées
WO2022046922A2 (fr) 2020-08-26 2022-03-03 Marengo Therapeutics, Inc. Molécules d'anticorps se liant à nkp30 et utilisations associees
KR20240004462A (ko) 2021-04-08 2024-01-11 마렝고 테라퓨틱스, 인크. Tcr에 결합하는 다기능성 분자 및 이의 용도

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US5773253A (en) * 1993-01-22 1998-06-30 Bristol-Myers Squibb Company MYPPPY variants of CTL A4 and uses thereof
AUPP221098A0 (en) * 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
EP0947582A1 (fr) * 1998-03-31 1999-10-06 Innogenetics N.V. Une structure polypeptidique utilisable comme un squelette

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011415A (zh) * 2008-10-20 2017-08-04 光州科学技术院 双齿肽结合物

Also Published As

Publication number Publication date
AU4499499A (en) 2000-10-23
EP1163339A1 (fr) 2001-12-19
WO2000060070A1 (fr) 2000-10-12

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Legal Events

Date Code Title Description
FZDE Discontinued