CA2365230C - Anti-gpr-9-6 and anti-teck antibodies and methods of identifying modulators of gpr-9-6 and teck functions - Google Patents
Anti-gpr-9-6 and anti-teck antibodies and methods of identifying modulators of gpr-9-6 and teck functions Download PDFInfo
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- CA2365230C CA2365230C CA2365230A CA2365230A CA2365230C CA 2365230 C CA2365230 C CA 2365230C CA 2365230 A CA2365230 A CA 2365230A CA 2365230 A CA2365230 A CA 2365230A CA 2365230 C CA2365230 C CA 2365230C
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| PCT/US2000/006240 WO2000053635A1 (en) | 1999-03-11 | 2000-03-10 | Anti-gpr-9-6 and anti-teck antibodies and methods of identifying modulators of gpr-9-6 and teck functions |
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| CA2365230A1 CA2365230A1 (en) | 2000-09-14 |
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| RU2412202C2 (ru) | 2004-06-21 | 2011-02-20 | Медарекс, Инк. | Антитела рецептора 1 интерферона альфа и их применение |
| ES2434852T3 (es) * | 2005-04-21 | 2013-12-17 | Chemocentryx, Inc. | Anticuerpos que se unen a CCX-CKR2 |
| CA2883711A1 (en) | 2012-09-07 | 2014-03-13 | The Governors Of The University Of Alberta | Methods and compositions for diagnosis of inflammatory liver disease |
| EP2876114A1 (en) * | 2013-11-25 | 2015-05-27 | Consejo Superior De Investigaciones Científicas | Antibodies against CCR9 and applications thereof |
| WO2017140793A1 (en) | 2016-02-16 | 2017-08-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Modulators of ccr9 for treating tumor resistance to immune responses |
| EP3416640A1 (en) | 2016-02-16 | 2018-12-26 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Modulators of tumor immune resistance for the treatment of cancer |
| CN110087530A (zh) | 2016-12-07 | 2019-08-02 | 普罗根尼蒂公司 | 胃肠道检测方法、装置和系统 |
| WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN118843478A (zh) | 2022-02-03 | 2024-10-25 | 圣洛克生物制药有限公司 | 用于癌症的包括抗ccr9抗体和长春新碱的联合疗法 |
| JP7368678B1 (ja) * | 2023-04-26 | 2023-10-25 | イミュニティリサーチ株式会社 | Ｃｄ４＋ｔ細胞集団中の特定の細胞亜集団の相対量の測定方法 |
| EP4578874A1 (en) | 2023-12-29 | 2025-07-02 | SunRock Biopharma S.L. | Anti-ccr9 antibody |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US18167A (en) * | 1857-09-08 | Improvement in blast-furnaces | ||
| US5440021A (en) * | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| US5652133A (en) | 1993-01-28 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cloning and expression of the human macrophage inflammatory protein-1.alpha.α) /rantes receptor |
| ATE428785T1 (de) * | 1996-03-01 | 2009-05-15 | Euroscreen Sa | Aktive und inactive cc-chemokinrezeptoren und nukleinsäuremoleküle, die für diesen rezeptor kodieren |
| IL127551A0 (en) † | 1996-06-17 | 1999-10-28 | Human Genome Sciences Inc | Chemokine beta-15 |
| US5981231A (en) | 1996-06-17 | 1999-11-09 | Human Genome Sciences, Inc. | Polynucleotides encoding chemokine β-15 |
| US6723520B2 (en) * | 1996-07-05 | 2004-04-20 | Schering Corporation | Antibodies that bind chemokine teck |
| EP0909321A2 (en) | 1996-07-05 | 1999-04-21 | Schering Corporation | Mammalian chemokine reagents |
| ATE360689T1 (de) * | 1996-09-10 | 2007-05-15 | Kocher Theodor Inst | Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung |
| AU6132698A (en) | 1997-01-23 | 1998-08-18 | Schering Corporation | Mammalian chemokines; receptors; reagents; uses |
| EP0878542A3 (en) * | 1997-04-22 | 2000-04-19 | Smithkline Beecham Corporation | cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor |
| WO1999007738A2 (en) * | 1997-08-06 | 1999-02-18 | Regeneron Pharmaceuticals, Inc. | Human orphan receptor ntr-1 |
| US6329159B1 (en) | 1999-03-11 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function |
| YU78601A (sh) * | 1999-05-05 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže |
| CA2396779A1 (en) * | 2000-01-07 | 2001-07-12 | Stichting Klinishce Farmacologie Groningen | Gene therapy to promote angiogenesis and/or the treatment of heart failure |
| CN101077867B (zh) | 2002-11-18 | 2012-10-10 | 坎莫森特里克斯公司 | 芳基磺酰胺 |
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| US7381412B2 (en) | 2008-06-03 |
| JP5112578B2 (ja) | 2013-01-09 |
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| ATE517123T1 (de) | 2011-08-15 |
| US20030022238A1 (en) | 2003-01-30 |
| US20050181501A1 (en) | 2005-08-18 |
| US6884574B2 (en) | 2005-04-26 |
| US20020119504A1 (en) | 2002-08-29 |
| JP2002542157A (ja) | 2002-12-10 |
| JP2012012402A (ja) | 2012-01-19 |
| AU3522600A (en) | 2000-09-28 |
| US7485301B2 (en) | 2009-02-03 |
| WO2000053635A1 (en) | 2000-09-14 |
| JP5933204B2 (ja) | 2016-06-08 |
| US6689570B2 (en) | 2004-02-10 |
| EP1157043A1 (en) | 2001-11-28 |
| EP1157043B1 (en) | 2011-07-20 |
| US20020141991A1 (en) | 2002-10-03 |
| AU771603B2 (en) | 2004-04-01 |
| CA2365230A1 (en) | 2000-09-14 |
| EP1157043B2 (en) | 2015-07-22 |
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