CA2364739A1 - Regulateur de la phosphorylation intracellulaire - Google Patents

Regulateur de la phosphorylation intracellulaire Download PDF

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Publication number
CA2364739A1
CA2364739A1 CA002364739A CA2364739A CA2364739A1 CA 2364739 A1 CA2364739 A1 CA 2364739A1 CA 002364739 A CA002364739 A CA 002364739A CA 2364739 A CA2364739 A CA 2364739A CA 2364739 A1 CA2364739 A1 CA 2364739A1
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CA
Canada
Prior art keywords
leu
ser
glu
hrip
val
Prior art date
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Abandoned
Application number
CA002364739A
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English (en)
Inventor
Olga Bandman
Y. Tom Tang
Henry Yue
Jennifer L. Hillman
Mariah R. Baughn
Yalda Azimzai
Dyung Aina M. Lu
Janice Au-Young
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Incyte Corp
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Individual
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Publication date
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Publication of CA2364739A1 publication Critical patent/CA2364739A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01037—Protein kinase (2.7.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)
    • C—CHEMISTRY; METALLURGY
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

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  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
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Abstract

L'invention concerne des régulateurs humains de la phosphorylation intracellulaire (HRIP) et des polynucléotides qui identifient et codent HRIP. Elle concerne aussi un vecteur d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. L'invention concerne enfin des procédés de diagnostic, de traitement ou de prévention des troubles associés à l'expression de HRIP.
CA002364739A 1999-03-18 2000-03-17 Regulateur de la phosphorylation intracellulaire Abandoned CA2364739A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12559399P 1999-03-18 1999-03-18
US13504999P 1999-05-20 1999-05-20
US14318899P 1999-07-09 1999-07-09
US60/143,188 1999-07-09
US60/135,049 1999-07-09
US60/125,593 1999-07-09
PCT/US2000/007277 WO2000055332A2 (fr) 1999-03-18 2000-03-17 Regulateur de la phosphorylation intracellulaire

Publications (1)

Publication Number Publication Date
CA2364739A1 true CA2364739A1 (fr) 2000-09-21

Family

ID=27383262

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002364739A Abandoned CA2364739A1 (fr) 1999-03-18 2000-03-17 Regulateur de la phosphorylation intracellulaire

Country Status (5)

Country Link
EP (1) EP1192257A2 (fr)
JP (1) JP2002538827A (fr)
AU (1) AU3899600A (fr)
CA (1) CA2364739A1 (fr)
WO (1) WO2000055332A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377135A1 (fr) 1999-04-23 2000-11-02 Ceptyr, Inc. Kinase phosphatase dsp-10 a double specificite activee par un mitogene
DE60027295T2 (de) * 1999-05-13 2007-01-18 Johnson & Johnson Pharmaceutical Research & Development, Llc Sphingosinekinase
JP2003501038A (ja) * 1999-05-28 2003-01-14 スージェン・インコーポレーテッド 蛋白質キナーゼ
WO2001012819A2 (fr) * 1999-08-13 2001-02-22 Sugen, Inc. Nouvelles phosphatases de proteines et diagnostic et traitement des troubles lies a la phosphatase
WO2001031029A2 (fr) * 1999-10-28 2001-05-03 Warner-Lambert Company Gene de la sphingosine kinase humaine
US6858427B2 (en) * 2000-02-14 2005-02-22 Genentech, Inc. Sphingosine kinases
IL151533A0 (en) 2000-02-29 2003-04-10 Mitsubishi Pharma Corp Novel cyclic amide derivatives
US20020102693A1 (en) * 2000-05-02 2002-08-01 Luche Ralf M. DSP-14 dual-specificity phosphatase
EP1227156A3 (fr) * 2001-01-30 2004-01-02 Aeomica, Inc. Protéine humaine contenant un domaine de protéine kinase
US20040096865A1 (en) * 2001-02-05 2004-05-20 Kohler Rainer H. Regulation of human tyrosine-specific protein phosphatase
EP1441034A4 (fr) * 2001-10-31 2006-06-07 Astellas Pharma Inc Methode d'evaluation d'inhibiteurs de la phosphatase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039446A2 (fr) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 proteines humaines secretees
US5955338A (en) * 1997-06-27 1999-09-21 Incyte Pharmaceuticals, Inc. Phosphatidylinositol 4,5-bisphosphate 5-phosphatase
US6235512B1 (en) * 1997-07-01 2001-05-22 Tularik Inc. IKK-α proteins, nucleic acids and methods

Also Published As

Publication number Publication date
EP1192257A2 (fr) 2002-04-03
WO2000055332A2 (fr) 2000-09-21
WO2000055332A3 (fr) 2002-01-10
AU3899600A (en) 2000-10-04
JP2002538827A (ja) 2002-11-19

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