CA2364569A1 - Non-ribosomal peptide synthetases, method for producing same and the use thereof - Google Patents

Non-ribosomal peptide synthetases, method for producing same and the use thereof Download PDF

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Publication number
CA2364569A1
CA2364569A1 CA002364569A CA2364569A CA2364569A1 CA 2364569 A1 CA2364569 A1 CA 2364569A1 CA 002364569 A CA002364569 A CA 002364569A CA 2364569 A CA2364569 A CA 2364569A CA 2364569 A1 CA2364569 A1 CA 2364569A1
Authority
CA
Canada
Prior art keywords
ribosomal
altered
seq
domain
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002364569A
Other languages
English (en)
French (fr)
Inventor
Mohamed A. Marahiel
Torsten Stachelhaus
Henning Mootz
Dirk Konz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2364569A1 publication Critical patent/CA2364569A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002364569A 1999-03-03 2000-02-28 Non-ribosomal peptide synthetases, method for producing same and the use thereof Abandoned CA2364569A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19909146A DE19909146A1 (de) 1999-03-03 1999-03-03 Verfahren zur gezielten biologischen Synthese von Peptiden
DE19909146.3 1999-03-03
PCT/EP2000/001652 WO2000052152A1 (de) 1999-03-03 2000-02-28 Nicht-ribosomale peptidsynthetika, verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
CA2364569A1 true CA2364569A1 (en) 2000-09-08

Family

ID=7899460

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002364569A Abandoned CA2364569A1 (en) 1999-03-03 2000-02-28 Non-ribosomal peptide synthetases, method for producing same and the use thereof

Country Status (8)

Country Link
EP (1) EP1159416A1 (de)
JP (1) JP2002537806A (de)
CN (1) CN1342201A (de)
AU (1) AU3425700A (de)
CA (1) CA2364569A1 (de)
DE (1) DE19909146A1 (de)
IL (1) IL145004A0 (de)
WO (1) WO2000052152A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3648109A4 (de) * 2017-06-30 2020-06-24 Nec Corporation Prognosevorrichtung, prognoseverfahren, speichermedium mit gespeichertem prognoseprogramm und genetische inferenzvorrichtung

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
ATE331028T1 (de) * 1999-04-16 2006-07-15 Kosan Biosciences Inc Multi-plasmid verfahren zur herstellung von grossen bibliotheken von polyketiden und nicht- ribosomalen peptiden
DE19951196A1 (de) * 1999-10-22 2001-05-10 Mohamed A Marahiel Massgeschneiderte Peptidsynthetasen und ihre Verwendung
DE10340068A1 (de) * 2003-08-28 2005-03-24 TransMIT Gesellschaft für Technologietransfer mbH Substrate für die Inhibierung der Adenylierungsdomänen nicht-ribosomaler Peptidsynthetasen
CN101217970A (zh) 2004-01-30 2008-07-09 得克萨斯农业及机械体系综合大学 一族新型肽的组合物、方法和用途
EP2084270B1 (de) * 2006-10-05 2013-11-20 DSM Sinochem Pharmaceuticals Netherlands B.V. Herstellung von beta-lactam-antibiotika
WO2012001169A1 (en) * 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
US20150167040A1 (en) * 2012-08-06 2015-06-18 Danisco Us Inc. Fungal Cells That Produce Decreased Amounts of Peptaibols
CN107849542A (zh) * 2015-08-05 2018-03-27 默克专利股份公司 人工非核糖体肽合成酶
WO2017137443A1 (en) 2016-02-08 2017-08-17 Johann Wolfgang Goethe-Universität Frankfurt am Main Artificial non-ribosomal peptide synthases and their use
EP3511445A1 (de) * 2018-01-15 2019-07-17 Johann Wolfgang Goethe-Universität Frankfurt System zur montage und modifizierung von nichtribosomalen peptidsynthasen
CN111575251B (zh) * 2020-05-29 2022-03-11 上海交通大学 一种用于达托霉素生物合成的dptC1突变体的构建
CN113278601B (zh) * 2021-05-17 2022-07-08 浙江工业大学 一种腺苷酰化蛋白a6突变体及其编码基因与应用
WO2024038117A1 (en) 2022-08-16 2024-02-22 Johann Wolfgang Goethe-Universität Frankfurt Method and means for engineering non-ribosomal peptides
CN117384924B (zh) * 2023-12-11 2024-06-25 中国农业科学院生物技术研究所 一种基于酶结构域拆分的多肽生物合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
IT1277466B1 (it) * 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3648109A4 (de) * 2017-06-30 2020-06-24 Nec Corporation Prognosevorrichtung, prognoseverfahren, speichermedium mit gespeichertem prognoseprogramm und genetische inferenzvorrichtung
US11557372B2 (en) 2017-06-30 2023-01-17 Nec Corporation Prediction device, gene estimation device, prediction method, and non-transitory recording medium

Also Published As

Publication number Publication date
DE19909146A1 (de) 2000-09-28
EP1159416A1 (de) 2001-12-05
JP2002537806A (ja) 2002-11-12
CN1342201A (zh) 2002-03-27
IL145004A0 (en) 2002-06-30
AU3425700A (en) 2000-09-21
WO2000052152A1 (de) 2000-09-08

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Legal Events

Date Code Title Description
FZDE Discontinued