IL145004A0 - Non-ribosomal peptide synthetases, method for the production thereof and use thereof - Google Patents

Non-ribosomal peptide synthetases, method for the production thereof and use thereof

Info

Publication number
IL145004A0
IL145004A0 IL14500400A IL14500400A IL145004A0 IL 145004 A0 IL145004 A0 IL 145004A0 IL 14500400 A IL14500400 A IL 14500400A IL 14500400 A IL14500400 A IL 14500400A IL 145004 A0 IL145004 A0 IL 145004A0
Authority
IL
Israel
Prior art keywords
production
ribosomal peptide
peptide synthetases
synthetases
ribosomal
Prior art date
Application number
IL14500400A
Inventor
A Mohamed Marahiel
Torsten Stachelhaus
Henning Mootz
Dirk Konz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of IL145004A0 publication Critical patent/IL145004A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
IL14500400A 1999-03-03 2000-02-28 Non-ribosomal peptide synthetases, method for the production thereof and use thereof IL145004A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19909146A DE19909146A1 (en) 1999-03-03 1999-03-03 Process for the targeted biological synthesis of peptides
PCT/EP2000/001652 WO2000052152A1 (en) 1999-03-03 2000-02-28 Non-ribosomal peptide synthetases, method for producing same and the use thereof

Publications (1)

Publication Number Publication Date
IL145004A0 true IL145004A0 (en) 2002-06-30

Family

ID=7899460

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14500400A IL145004A0 (en) 1999-03-03 2000-02-28 Non-ribosomal peptide synthetases, method for the production thereof and use thereof

Country Status (8)

Country Link
EP (1) EP1159416A1 (en)
JP (1) JP2002537806A (en)
CN (1) CN1342201A (en)
AU (1) AU3425700A (en)
CA (1) CA2364569A1 (en)
DE (1) DE19909146A1 (en)
IL (1) IL145004A0 (en)
WO (1) WO2000052152A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
EP1171583B1 (en) * 1999-04-16 2006-06-21 Kosan Biosciences, Inc. A multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
DE19951196A1 (en) * 1999-10-22 2001-05-10 Mohamed A Marahiel Tailored peptide synthetases and their use
DE10340068A1 (en) * 2003-08-28 2005-03-24 TransMIT Gesellschaft für Technologietransfer mbH New inhibitors of non-ribosomal peptide synthetase adenylation domains useful in therapeutic compositions comprise aminoacyl sulfamoyl adenosine derivatives
BRPI0507186A (en) 2004-01-30 2007-06-26 Texas A & M Univ Sys composition, methods and uses for a new family of peptides
SI2084270T1 (en) * 2006-10-05 2014-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Production of beta-lactam antibiotics
US8945898B2 (en) * 2010-07-01 2015-02-03 Dsm Ip Assets B.V. Recombinant host cell with deficiency in non-ribosomal peptide synthase production
US20150167040A1 (en) * 2012-08-06 2015-06-18 Danisco Us Inc. Fungal Cells That Produce Decreased Amounts of Peptaibols
WO2017020983A1 (en) 2015-08-05 2017-02-09 Merck Patent Gmbh Artificial non-ribosomal peptide synthetases
EP3414323A1 (en) 2016-02-08 2018-12-19 Johann Wolfgang Goethe-Universität Frankfurt am Main Artificial non-ribosomal peptide synthases and their use
WO2019003441A1 (en) 2017-06-30 2019-01-03 日本電気株式会社 Forecasting device, forecasting method, storage medium stored with forecasting program, and genetic inference device
EP3511445A1 (en) * 2018-01-15 2019-07-17 Johann Wolfgang Goethe-Universität Frankfurt System for the assembly and modification of non-ribosomal peptide synthases
CN111575251B (en) * 2020-05-29 2022-03-11 上海交通大学 Construction of dptC1 mutant for daptomycin biosynthesis
CN113278601B (en) * 2021-05-17 2022-07-08 浙江工业大学 Adenylylation protein A6 mutant and coding gene and application thereof
WO2024038117A1 (en) 2022-08-16 2024-02-22 Johann Wolfgang Goethe-Universität Frankfurt Method and means for engineering non-ribosomal peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264712B1 (en) * 1993-07-13 1996-10-04 Eniricerche Spa BIOLOGICAL SYNTHESIS METHOD OF PEPTIDES
IT1277466B1 (en) * 1995-08-09 1997-11-10 Eniricerche Spa ENGINEERED PEPTIDE SYNTHETASES AND THEIR USE FOR THE NON-RIBOSOMAL PRODUCTION OF PEPTIDES

Also Published As

Publication number Publication date
WO2000052152A1 (en) 2000-09-08
CN1342201A (en) 2002-03-27
DE19909146A1 (en) 2000-09-28
JP2002537806A (en) 2002-11-12
AU3425700A (en) 2000-09-21
CA2364569A1 (en) 2000-09-08
EP1159416A1 (en) 2001-12-05

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