CA2363833C - Minimally invasive apparatus and method for testing lesions of the oral cavity and similar epithelium - Google Patents

Minimally invasive apparatus and method for testing lesions of the oral cavity and similar epithelium Download PDF

Info

Publication number
CA2363833C
CA2363833C CA002363833A CA2363833A CA2363833C CA 2363833 C CA2363833 C CA 2363833C CA 002363833 A CA002363833 A CA 002363833A CA 2363833 A CA2363833 A CA 2363833A CA 2363833 C CA2363833 C CA 2363833C
Authority
CA
Canada
Prior art keywords
cells
epithelial tissue
detect abnormal
body according
abnormal cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002363833A
Other languages
English (en)
French (fr)
Other versions
CA2363833A1 (en
Inventor
Drore Eisen
Stephen Frist
Joel Recht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CDX LABORATORIES Inc
Original Assignee
Oralscan Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/298,219 external-priority patent/US6297044B1/en
Priority claimed from US09/298,218 external-priority patent/US6284482B1/en
Application filed by Oralscan Laboratories Inc filed Critical Oralscan Laboratories Inc
Publication of CA2363833A1 publication Critical patent/CA2363833A1/en
Application granted granted Critical
Publication of CA2363833C publication Critical patent/CA2363833C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Theoretical Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Sewage (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002363833A 1999-02-23 2000-01-12 Minimally invasive apparatus and method for testing lesions of the oral cavity and similar epithelium Expired - Fee Related CA2363833C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12125599P 1999-02-23 1999-02-23
US60/121,255 1999-02-23
US09/298,219 1999-04-23
US09/298,218 1999-04-23
US09/298,219 US6297044B1 (en) 1999-02-23 1999-04-23 Minimally invasive apparatus for testing lesions of the oral cavity and similar epithelium
US09/298,218 US6284482B1 (en) 1999-04-23 1999-04-23 Method for detection of abnormal keratinization in epithelial tissue
PCT/US2000/000743 WO2000051066A1 (en) 1999-02-23 2000-01-12 Minimally invasive apparatus and method for testing lesions of the oral cavity and similar epithelium

Publications (2)

Publication Number Publication Date
CA2363833A1 CA2363833A1 (en) 2000-08-31
CA2363833C true CA2363833C (en) 2007-04-03

Family

ID=27382597

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002363833A Expired - Fee Related CA2363833C (en) 1999-02-23 2000-01-12 Minimally invasive apparatus and method for testing lesions of the oral cavity and similar epithelium

Country Status (12)

Country Link
US (1) US20020012938A1 (enExample)
EP (1) EP1155381B1 (enExample)
JP (1) JP4748628B2 (enExample)
CN (1) CN100339862C (enExample)
AT (1) ATE472775T1 (enExample)
AU (2) AU769471B2 (enExample)
CA (1) CA2363833C (enExample)
DE (1) DE60044604D1 (enExample)
DK (1) DK1155381T3 (enExample)
IL (2) IL144933A0 (enExample)
PT (1) PT1155381E (enExample)
WO (1) WO2000051066A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7390628B2 (en) * 2003-12-23 2008-06-24 University Of Florida Research Foundation, Inc. Microparticle-based diagnostic methods
US8099600B2 (en) * 2004-08-23 2012-01-17 International Business Machines Corporation Content distribution site spoofing detection and prevention
KR101392106B1 (ko) 2005-05-09 2014-05-07 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
JP2007114076A (ja) * 2005-10-21 2007-05-10 Pola Chem Ind Inc 角層細胞の画像の調整方法
CN105740641A (zh) 2009-10-19 2016-07-06 提拉诺斯公司 集成的健康数据采集和分析系统
EP3372980A4 (en) * 2015-11-05 2019-07-17 Shiseido Company Ltd. STRATUM CORNEUM COLLECTIBLE TOOL AND STRATUM CORNEUM COLLECTION / DETECTION KIT
CN106570505B (zh) * 2016-11-01 2020-08-21 北京昆仑医云科技有限公司 对组织病理图像进行分析的方法和系统
US12235272B2 (en) 2020-01-13 2025-02-25 New York University Screening and assessment of potentially malignant oral lesions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847990A (en) * 1956-03-20 1958-08-19 Ayre James Ernest Instrument for obtaining cells for cytodiagnosis
JPS5615731A (en) * 1979-07-20 1981-02-16 Olympus Optical Co Manufacture of cell diagnosing brush
US5740270A (en) * 1988-04-08 1998-04-14 Neuromedical Systems, Inc. Automated cytological specimen classification system and method
US5623941A (en) * 1988-05-10 1997-04-29 Nils Stormby Cervical sampling velour brush
CA1340245C (en) * 1989-04-21 1998-12-15 John Samuel Monoclonal antibody for differentiation of squamous cell carcinoma antigens and method of use for same
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5184626A (en) * 1991-05-21 1993-02-09 Hicken William J Brush overlay Pap smear
JPH08501228A (ja) * 1992-08-07 1996-02-13 ジェンザイム・コーポレイション 非液体細胞試料の採取方法
US5733721A (en) * 1992-11-20 1998-03-31 The Board Of Regents Of The University Of Oklahoma Cell analysis method using quantitative fluorescence image analysis
AU3585495A (en) * 1994-09-20 1996-04-09 Neopath, Inc. Biological analysis system self-calibration apparatus
US5713369A (en) * 1995-09-13 1998-02-03 Vance Products Inc. Uterine endometrial tissue sample brush
DE69942935D1 (de) * 1998-07-23 2010-12-23 Cdx Lab Inc Gerät zur gewinnung einer transpithelialen probe einer körperoberfläche ohne diese aufzureissen

Also Published As

Publication number Publication date
CA2363833A1 (en) 2000-08-31
EP1155381B1 (en) 2010-06-30
WO2000051066A1 (en) 2000-08-31
EP1155381A1 (en) 2001-11-21
EP1155381A4 (en) 2006-01-04
CN100339862C (zh) 2007-09-26
AU2004201764A1 (en) 2004-05-27
IL144933A0 (en) 2002-06-30
IL144933A (en) 2006-07-05
DE60044604D1 (de) 2010-08-12
JP4748628B2 (ja) 2011-08-17
JP2002538441A (ja) 2002-11-12
US20020012938A1 (en) 2002-01-31
AU2004201764B2 (en) 2007-11-22
DK1155381T3 (da) 2010-11-01
ATE472775T1 (de) 2010-07-15
CN1341244A (zh) 2002-03-20
PT1155381E (pt) 2010-10-11
AU2412000A (en) 2000-09-14
AU769471B2 (en) 2004-01-29
AU2004201764B8 (en) 2004-05-27

Similar Documents

Publication Publication Date Title
US6297044B1 (en) Minimally invasive apparatus for testing lesions of the oral cavity and similar epithelium
Guitera et al. The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face
US5733739A (en) System and method for diagnosis of disease by infrared analysis of human tissues and cells
KR101548032B1 (ko) 세포의 질병 검출에 유용한 세포 스펙트럼의 재구성 방법
Green et al. Computer image analysis of pigmented skin lesions
MX2014002843A (es) Sistema y metodo para la deteccion de anormalidades en una muestra biologica.
KR20080007447A (ko) 자동 이미징 프로세스 및 장치
CA2363833C (en) Minimally invasive apparatus and method for testing lesions of the oral cavity and similar epithelium
CN113674839B (zh) 无创成像筛查与微创取样核酸分型的联合检测系统
WO2000045166A1 (en) Measurement of lesion progression via mapping of chromatin texture features along progression curve
Xue et al. Automatic detection of oral lesion measurement ruler toward computer-aided image-based oral cancer screening
Atlamazoglou et al. Texture analysis of fluorescence microscopic images of colonic tissue sections
US6284482B1 (en) Method for detection of abnormal keratinization in epithelial tissue
Pellacani et al. Digital videomicroscopy with image analysis and automatic classification as an aid for diagnosis of Spitz nevus
WO2020195829A1 (ja) 皮膚の状態を評価する方法
Osborne et al. Machine classification of melanoma and nevi from skin lesions
Das et al. A Novel Analysis of Clinical Data and Image Processing Algorithms in Detection of Cervical Cancer
Bayot et al. Malignancy detection of candidate for basal cell carcinoma using image processing and artificial neural network
Pujari Comparison of the Efficacy of Sediment Cytology Over Exfoliative Cytology in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma
Cat et al. Enhancing the contrast of blood in cervical based on polarized imaging
Tabassum Yesmin Rahman et al. Image Based Methods Available For Early Detection of Oral Cancer: A Review
Meyer-Ebrecht et al. Diagnostic Cytometry
Challoob et al. Feature Extraction for Breast Cancer Classification: A Comparative Study for Multiple Subsets of Features
Alarcon et al. In Vivo Reflectance Confocal Microscopy in Dermatology
HK1156134B (en) Method of reconstituting cellular spectra useful for detecting cellular disorders

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20200113