CA2362355A1 - Effervescent laxatives - Google Patents
Effervescent laxatives Download PDFInfo
- Publication number
- CA2362355A1 CA2362355A1 CA002362355A CA2362355A CA2362355A1 CA 2362355 A1 CA2362355 A1 CA 2362355A1 CA 002362355 A CA002362355 A CA 002362355A CA 2362355 A CA2362355 A CA 2362355A CA 2362355 A1 CA2362355 A1 CA 2362355A1
- Authority
- CA
- Canada
- Prior art keywords
- peg
- formulation according
- effervescent
- formulation
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008141 laxative Substances 0.000 title description 33
- 229940125722 laxative agent Drugs 0.000 title description 8
- 206010010774 Constipation Diseases 0.000 claims abstract description 11
- 230000003204 osmotic effect Effects 0.000 claims abstract description 8
- 241000124008 Mammalia Species 0.000 claims abstract description 7
- 206010056325 Faecaloma Diseases 0.000 claims abstract description 5
- 208000008415 Fecal Impaction Diseases 0.000 claims abstract description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 57
- 229920001223 polyethylene glycol Polymers 0.000 claims description 53
- 239000002202 Polyethylene glycol Substances 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 32
- 238000009472 formulation Methods 0.000 claims description 23
- 230000008878 coupling Effects 0.000 claims description 20
- 238000010168 coupling process Methods 0.000 claims description 20
- 238000005859 coupling reaction Methods 0.000 claims description 20
- 235000015165 citric acid Nutrition 0.000 claims description 19
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000011090 malic acid Nutrition 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 239000004150 EU approved colour Substances 0.000 claims description 2
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- RRPFCKLVOUENJB-UHFFFAOYSA-L disodium;2-aminoacetic acid;carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O.NCC(O)=O RRPFCKLVOUENJB-UHFFFAOYSA-L 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 239000001361 adipic acid Substances 0.000 claims 1
- 238000004040 coloring Methods 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 10
- 230000002475 laxative effect Effects 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 20
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 16
- 239000000243 solution Substances 0.000 description 13
- 239000011521 glass Substances 0.000 description 9
- 239000003792 electrolyte Substances 0.000 description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 description 8
- 230000002378 acidificating effect Effects 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000008143 stimulant laxative Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 239000000799 cathartic agent Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000000112 colonic effect Effects 0.000 description 3
- 239000008151 electrolyte solution Substances 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 3
- 235000015497 potassium bicarbonate Nutrition 0.000 description 3
- 239000011736 potassium bicarbonate Substances 0.000 description 3
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010007269 Carcinogenicity Diseases 0.000 description 2
- 235000006693 Cassia laevigata Nutrition 0.000 description 2
- 241000522641 Senna Species 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 229960000503 bisacodyl Drugs 0.000 description 2
- 231100000260 carcinogenicity Toxicity 0.000 description 2
- 230000007670 carcinogenicity Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- QBPFLULOKWLNNW-UHFFFAOYSA-N chrysazin Chemical compound O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O QBPFLULOKWLNNW-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 231100000025 genetic toxicology Toxicity 0.000 description 2
- 230000001738 genotoxic effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 229940124513 senna glycoside Drugs 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-L 2-(carboxymethyl)-2-hydroxysuccinate Chemical compound [O-]C(=O)CC(O)(C(=O)O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-L 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 239000010369 Cascara Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000012258 Diverticular disease Diseases 0.000 description 1
- 206010013554 Diverticulum Diseases 0.000 description 1
- 241000556215 Frangula purshiana Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- -1 alkaline earth metal carbonate Chemical class 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229940058505 cascara Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940081970 citrucel Drugs 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 229940105597 colyte Drugs 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 229960001577 dantron Drugs 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229940056944 golytely Drugs 0.000 description 1
- 208000024798 heartburn Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 229940042003 metamucil Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 229940060946 miralax Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229940118092 nulytely Drugs 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229940050929 polyethylene glycol 3350 Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 230000001543 purgative effect Effects 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12108999P | 1999-02-22 | 1999-02-22 | |
| US60/121,089 | 1999-02-22 | ||
| PCT/US2000/004701 WO2000048585A1 (en) | 1999-02-22 | 2000-02-22 | Effervescent laxatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2362355A1 true CA2362355A1 (en) | 2000-08-24 |
Family
ID=22394460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002362355A Abandoned CA2362355A1 (en) | 1999-02-22 | 2000-02-22 | Effervescent laxatives |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1154765A4 (hu) |
| JP (1) | JP2002537248A (hu) |
| KR (1) | KR20010102323A (hu) |
| CN (1) | CN1341016A (hu) |
| AU (1) | AU3604600A (hu) |
| BR (1) | BR0008385A (hu) |
| CA (1) | CA2362355A1 (hu) |
| CZ (1) | CZ20013043A3 (hu) |
| EA (1) | EA003064B1 (hu) |
| HK (1) | HK1043046A1 (hu) |
| HU (1) | HUP0105351A3 (hu) |
| PL (1) | PL349360A1 (hu) |
| WO (1) | WO2000048585A1 (hu) |
| ZA (1) | ZA200106888B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048901A (en) * | 1999-04-20 | 2000-04-11 | Braintree Laboratories, Inc. | Method of reducing intestinal gas, cramping and anorectal irritation |
| DE102004023288A1 (de) * | 2004-05-11 | 2005-12-15 | Stefan Spiess | Macrogol-Präparat |
| KR20080030549A (ko) * | 2004-12-30 | 2008-04-04 | 기븐 이미징 리미티드 | 체내 검사를 위한 장치, 시스템 및 방법 |
| CN101002832B (zh) * | 2006-09-02 | 2011-01-05 | 江西农业大学 | 一种润肠通便速溶颗粒剂 |
| PL2421373T3 (pl) * | 2009-04-21 | 2020-03-31 | Dale R. Bachwich | Układ do płukania okrężnicy |
| CA2825808C (en) * | 2011-01-28 | 2020-09-01 | William A. Shaver | Method, composition and package for bowel cleansing |
| JP2014532725A (ja) * | 2011-11-06 | 2014-12-08 | エスエスブイ セラピューテクス，リミティド ライアビリティ カンパニー | 下剤および食品サプリメントとしての濃縮プルーンおよびプレバイオティクスの製剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB942743A (en) * | 1959-05-22 | 1963-11-27 | Welloome Foundation Ltd | Oestrogen preparations and the manufacture thereof |
| GB1518364A (en) * | 1976-05-05 | 1978-07-19 | Beecham Group Ltd | Pharmaceutical composition |
| US4093710A (en) * | 1976-07-07 | 1978-06-06 | Sandoz, Inc. | Rapid dissolving effervescent granules |
| JPH01283222A (ja) * | 1988-05-10 | 1989-11-14 | Tokai Kapuseru Kk | ピコスルフアートナトリウム軟カプセル剤 |
| IT1229568B (it) * | 1989-04-17 | 1991-09-04 | Giuliani Spa | Composizione farmaceutica per uso orale adatta all'impiego nel lavaggio gastro intestinale, in particolare per uso diagnostico, oppure come lassativo catartico. |
| US4946939A (en) * | 1989-05-30 | 1990-08-07 | The Dow Chemical Company | High purity polyether polyols |
| US5710183A (en) * | 1995-07-14 | 1998-01-20 | Halow; George M. | Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent |
| US6048901A (en) * | 1999-04-20 | 2000-04-11 | Braintree Laboratories, Inc. | Method of reducing intestinal gas, cramping and anorectal irritation |
-
2000
- 2000-02-22 CN CN00804156A patent/CN1341016A/zh active Pending
- 2000-02-22 PL PL00349360A patent/PL349360A1/xx not_active Application Discontinuation
- 2000-02-22 EP EP00914689A patent/EP1154765A4/en not_active Withdrawn
- 2000-02-22 HU HU0105351A patent/HUP0105351A3/hu unknown
- 2000-02-22 JP JP2000599377A patent/JP2002537248A/ja not_active Withdrawn
- 2000-02-22 KR KR1020017010689A patent/KR20010102323A/ko not_active Application Discontinuation
- 2000-02-22 WO PCT/US2000/004701 patent/WO2000048585A1/en not_active Application Discontinuation
- 2000-02-22 CA CA002362355A patent/CA2362355A1/en not_active Abandoned
- 2000-02-22 EA EA200100785A patent/EA003064B1/ru not_active IP Right Cessation
- 2000-02-22 BR BR0008385-2A patent/BR0008385A/pt not_active IP Right Cessation
- 2000-02-22 AU AU36046/00A patent/AU3604600A/en not_active Abandoned
- 2000-02-22 CZ CZ20013043A patent/CZ20013043A3/cs unknown
-
2001
- 2001-08-21 ZA ZA200106888A patent/ZA200106888B/en unknown
-
2002
- 2002-04-12 HK HK02102792.4A patent/HK1043046A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3604600A (en) | 2000-09-04 |
| CN1341016A (zh) | 2002-03-20 |
| HK1043046A1 (zh) | 2002-09-06 |
| HUP0105351A3 (en) | 2004-06-28 |
| EA200100785A1 (ru) | 2002-04-25 |
| CZ20013043A3 (cs) | 2001-11-14 |
| EP1154765A1 (en) | 2001-11-21 |
| EP1154765A4 (en) | 2004-12-01 |
| KR20010102323A (ko) | 2001-11-15 |
| PL349360A1 (en) | 2002-07-15 |
| EA003064B1 (ru) | 2002-12-26 |
| HUP0105351A2 (hu) | 2002-05-29 |
| JP2002537248A (ja) | 2002-11-05 |
| WO2000048585A1 (en) | 2000-08-24 |
| ZA200106888B (en) | 2002-09-27 |
| BR0008385A (pt) | 2002-01-29 |
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