CA2360334A1 - Manipulation de l'expression d'un isoprenoide - Google Patents

Manipulation de l'expression d'un isoprenoide Download PDF

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Publication number
CA2360334A1
CA2360334A1 CA002360334A CA2360334A CA2360334A1 CA 2360334 A1 CA2360334 A1 CA 2360334A1 CA 002360334 A CA002360334 A CA 002360334A CA 2360334 A CA2360334 A CA 2360334A CA 2360334 A1 CA2360334 A1 CA 2360334A1
Authority
CA
Canada
Prior art keywords
plant
dxps
cell
isoprenoid
organism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002360334A
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English (en)
Inventor
Peter Michael Bramley
Mark Harker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Royal Holloway University of London
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2360334A1 publication Critical patent/CA2360334A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne une technique permettant de manipuler l'expression d'un isoprénoïde dans une cellule ou dans un organisme possédant une voie de synthèse du diphosphate isopentyle indépendante du mévalonate. Cette technique consiste à altérer l'activité de l'enzyme 1-déoxy-D-xylulose-5-phosphate synthase (DXPS), ou d'un équivalent fonctionnel, d'un dérivé ou d'un bioprécurseur de celui-ci. L'invention concerne également une cellule transgénique, un tissu ou un organisme comprenant une voie de biosynthèse IPP indépendante du mévalonate, lesquels cellule, tissu ou organisme comprennent au moins un transgène capable d'exprimer DXPS ou un équivalent fonctionnel, un dérivé ou un bioprécurseur de celui-ci.
CA002360334A 1999-01-28 2000-01-28 Manipulation de l'expression d'un isoprenoide Abandoned CA2360334A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9901902.8A GB9901902D0 (en) 1999-01-28 1999-01-28 Manipulating isoprenoid expression
GB9901902.8 1999-01-28
PCT/GB2000/000263 WO2000044912A1 (fr) 1999-01-28 2000-01-28 Manipulation de l'expression d'un isoprenoide

Publications (1)

Publication Number Publication Date
CA2360334A1 true CA2360334A1 (fr) 2000-08-03

Family

ID=10846673

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360334A Abandoned CA2360334A1 (fr) 1999-01-28 2000-01-28 Manipulation de l'expression d'un isoprenoide

Country Status (6)

Country Link
EP (1) EP1144652A1 (fr)
JP (1) JP2002535970A (fr)
AU (1) AU2121100A (fr)
CA (1) CA2360334A1 (fr)
GB (1) GB9901902D0 (fr)
WO (1) WO2000044912A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2175025A1 (fr) 1998-04-14 2010-04-14 Kyowa Hakko Bio Co., Ltd. Procédé de production de composés isoprénoides au moyen de micro-organismes
US6660507B2 (en) * 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
AU2002215352A1 (en) 2000-10-13 2002-04-22 University Of Utah Research Foundation Systems for screening antibacterial and herbicidal compounds
US7034140B2 (en) * 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
JP5035872B2 (ja) 2005-09-16 2012-09-26 株式会社ブリヂストン パラゴムノキの非メバロン酸経路でのイソペンテニル二リン酸生合成に関与する遺伝子群
KR101420889B1 (ko) 2006-05-26 2014-07-17 아미리스 인코퍼레이티드 생물 유기 화합물을 제조하기 위한 장치
EP2444415A1 (fr) * 2010-10-20 2012-04-25 Genoplante-Valor Allèles de synthase de 1-déoxy-D-xylulose 5-phosphate pour biosynthèse améliorée de terpène
CA3084263A1 (fr) 2017-12-07 2019-06-13 Zymergen Inc. Voies de biosynthese manipulees pour la production de (6e)-8-hydroxygeraniol par fermentation
EP3728212A1 (fr) 2017-12-21 2020-10-28 Zymergen Inc. Népétalactol oxydoréductases, népétalactol synthases et microbes capables de produire une népétalactone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190895B1 (en) * 1997-09-02 2001-02-20 Washington State University Research Foundation Nucleic and amino acid sequences relating to a novel transketolase, and methods for the expression thereof
DE19752700A1 (de) * 1997-11-28 1999-06-02 Hoechst Schering Agrevo Gmbh 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase
EP2175025A1 (fr) * 1998-04-14 2010-04-14 Kyowa Hakko Bio Co., Ltd. Procédé de production de composés isoprénoides au moyen de micro-organismes
IL138721A0 (en) * 1998-04-14 2001-10-31 Jomaa Hassan Process for identifying chemical active ingredients and active ingredients for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthesis pathway
AU3964599A (en) * 1998-05-13 1999-11-29 University Of Maryland Methods of modifying the production of isopentenyl pyrophosphate, dimethylallyl pyrophosphate and/or isoprenoids
WO2000008169A1 (fr) * 1998-08-05 2000-02-17 Sungene Gmbh & Co.Kgaa Sequence adn codant pour une 1-deoxy-d-xylulose-5-phosphate synthase et sa surproduction dans les plantes

Also Published As

Publication number Publication date
JP2002535970A (ja) 2002-10-29
EP1144652A1 (fr) 2001-10-17
AU2121100A (en) 2000-08-18
GB9901902D0 (en) 1999-03-17
WO2000044912A1 (fr) 2000-08-03

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