CA2359360C - Methode de criblage in vitro permettant d'identifier des partenaires de liaison selective pour recepteurs 5-ht5 - Google Patents
Methode de criblage in vitro permettant d'identifier des partenaires de liaison selective pour recepteurs 5-ht5 Download PDFInfo
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- CA2359360C CA2359360C CA2359360A CA2359360A CA2359360C CA 2359360 C CA2359360 C CA 2359360C CA 2359360 A CA2359360 A CA 2359360A CA 2359360 A CA2359360 A CA 2359360A CA 2359360 C CA2359360 C CA 2359360C
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- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne des partenaires de liaison sélectifs pour les récepteurs 5-HT5, ainsi que des procédés d'identification et de caractérisation de tels partenaires de liaison, notamment des procédés de criblage. Elle concerne également des compositions pharmaceutiques contenant ces partenaires de liaison, et leur utilisation pour le traitement d'affections cérébrovasculaires, telles que la migraine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19900674.1 | 1999-01-11 | ||
| DE19900674A DE19900674A1 (de) | 1999-01-11 | 1999-01-11 | Bindungspartner für 5-HT5-Rezeptoren zur Migränebehandlung |
| PCT/EP2000/000142 WO2000041472A2 (fr) | 1999-01-11 | 2000-01-11 | Partenaires de liaison pour les recepteurs 5-ht5 utilises pour le traitement de la migraine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2359360A1 CA2359360A1 (fr) | 2000-07-20 |
| CA2359360C true CA2359360C (fr) | 2012-11-27 |
Family
ID=7893919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2359360A Expired - Fee Related CA2359360C (fr) | 1999-01-11 | 2000-01-11 | Methode de criblage in vitro permettant d'identifier des partenaires de liaison selective pour recepteurs 5-ht5 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1144050A2 (fr) |
| JP (1) | JP2002540063A (fr) |
| CN (1) | CN1321635C (fr) |
| AU (1) | AU2289100A (fr) |
| CA (1) | CA2359360C (fr) |
| DE (1) | DE19900674A1 (fr) |
| MX (1) | MXPA01006986A (fr) |
| WO (1) | WO2000041472A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004008141A1 (de) | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| EP2308852A1 (fr) | 2005-08-21 | 2011-04-13 | Abbott GmbH & Co. KG | Composés 5-cycle-heteroaromates et leur utilisation en tant que partenaires de liaison des récepteurs 5-HT5 |
| EP1917244A2 (fr) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Composes guanidine a substitution hetaryl et utilisation en tant que partenaires de liaison pour des recepteurs de 5-ht5 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8770282A (en) * | 1981-08-27 | 1983-03-03 | Shaun R. Coughlin | Composition for the treatment of atherosclerosis |
| US5360735A (en) * | 1992-01-08 | 1994-11-01 | Synaptic Pharmaceutical Corporation | DNA encoding a human 5-HT1F receptor, vectors, and host cells |
| FR2693200B1 (fr) * | 1992-07-01 | 1994-08-19 | Inst Nat Sante Rech Med | Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations. |
| FR2701265B1 (fr) * | 1993-02-09 | 1995-04-07 | Inst Nat Sante Rech Med | Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations. |
-
1999
- 1999-01-11 DE DE19900674A patent/DE19900674A1/de not_active Withdrawn
-
2000
- 2000-01-11 EP EP00901526A patent/EP1144050A2/fr not_active Ceased
- 2000-01-11 MX MXPA01006986A patent/MXPA01006986A/es not_active IP Right Cessation
- 2000-01-11 AU AU22891/00A patent/AU2289100A/en not_active Abandoned
- 2000-01-11 WO PCT/EP2000/000142 patent/WO2000041472A2/fr active Application Filing
- 2000-01-11 CA CA2359360A patent/CA2359360C/fr not_active Expired - Fee Related
- 2000-01-11 CN CNB008046107A patent/CN1321635C/zh not_active Expired - Fee Related
- 2000-01-11 JP JP2000593096A patent/JP2002540063A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1342070A (zh) | 2002-03-27 |
| WO2000041472A3 (fr) | 2001-10-11 |
| AU2289100A (en) | 2000-08-01 |
| EP1144050A2 (fr) | 2001-10-17 |
| JP2002540063A (ja) | 2002-11-26 |
| MXPA01006986A (es) | 2002-09-18 |
| DE19900674A1 (de) | 2000-07-13 |
| CA2359360A1 (fr) | 2000-07-20 |
| WO2000041472A2 (fr) | 2000-07-20 |
| CN1321635C (zh) | 2007-06-20 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150112 |