CA2355738A1 - Derives de pename sulfone 3,6-disubstitues comme antibacteriens - Google Patents
Derives de pename sulfone 3,6-disubstitues comme antibacteriens Download PDFInfo
- Publication number
- CA2355738A1 CA2355738A1 CA002355738A CA2355738A CA2355738A1 CA 2355738 A1 CA2355738 A1 CA 2355738A1 CA 002355738 A CA002355738 A CA 002355738A CA 2355738 A CA2355738 A CA 2355738A CA 2355738 A1 CA2355738 A1 CA 2355738A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- hydrogen
- methyl
- pharmaceutically acceptable
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Abstract
L'invention concerne des composés représentés par les formules (I) et (II), dans lesquelles n vaut 0 ou 1, et si n=1, R est un noyau hétérocyclique à 5 ou 6 chaînons, hydroxy, halogène, oxo, carbamoyle, alcoxy, ou amino disubstitué ; si n=0, R est ester, cyano ou un groupe amide; X est CH ou NH; R¿3? est cyano, méthoxy, ou acétamido; R¿1? est hydrogène, alkyle, une charge négative, un cation sélectionné dans le groupe constitué par du sodium, du potassium, un tétraalkylammonium et un acyloxyalkyle, ou un alcoxycarbonyloxyalkyle; and R¿2? est hydrogène, acyle, un carbamoyle de silyle trisubstitué ou un résidu d'acide aminé; ou des sels pharmaceutiquement acceptables de ces composés.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23772699A | 1999-01-26 | 1999-01-26 | |
| US09/237,726 | 1999-01-26 | ||
| PCT/US2000/001630 WO2000043399A1 (fr) | 1999-01-26 | 2000-01-26 | Derives de pename sulfone 3,6-disubstitues comme antibacteriens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2355738A1 true CA2355738A1 (fr) | 2000-07-27 |
Family
ID=22894903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002355738A Abandoned CA2355738A1 (fr) | 1999-01-26 | 2000-01-26 | Derives de pename sulfone 3,6-disubstitues comme antibacteriens |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1144418A1 (fr) |
| JP (1) | JP2002535335A (fr) |
| KR (1) | KR20010101649A (fr) |
| CN (1) | CN1188417C (fr) |
| AU (1) | AU2624600A (fr) |
| BG (1) | BG105737A (fr) |
| BR (1) | BR0007729A (fr) |
| CA (1) | CA2355738A1 (fr) |
| CZ (1) | CZ20012691A3 (fr) |
| EA (1) | EA200100813A1 (fr) |
| HK (1) | HK1038747A1 (fr) |
| HU (1) | HUP0200013A3 (fr) |
| ID (1) | ID29400A (fr) |
| IL (1) | IL144116A0 (fr) |
| NO (1) | NO20013640L (fr) |
| PL (1) | PL349874A1 (fr) |
| SK (1) | SK10142001A3 (fr) |
| TR (1) | TR200102133T2 (fr) |
| WO (1) | WO2000043399A1 (fr) |
| ZA (1) | ZA200104323B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG174296A1 (en) * | 2009-03-10 | 2011-10-28 | Air Liquide | Cyclic amino compounds for low-k silylation |
| CN109422765B (zh) * | 2017-09-05 | 2020-08-28 | 香港理工大学深圳研究院 | C类β-内酰胺酶抑制剂及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2076812A (en) * | 1980-05-22 | 1981-12-09 | Ciba Geigy Ag | Penam-dioxide compounds, processes for their manufacture, and their use |
| EP0083977A1 (fr) * | 1982-01-11 | 1983-07-20 | Pfizer Inc. | Sulfone de l'acide 6-alpha-hydroxyméthylpénicillanique, en tant qu'inhibiteur de bêta-lactamase |
| US4562073A (en) * | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US4503040A (en) * | 1984-02-27 | 1985-03-05 | Pfizer Inc. | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
| US4591459A (en) * | 1984-12-03 | 1986-05-27 | Pfizer Inc. | Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides |
| TW383308B (en) * | 1993-08-24 | 2000-03-01 | Hoffmann La Roche | 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors |
-
2000
- 2000-01-26 KR KR1020017009276A patent/KR20010101649A/ko not_active Application Discontinuation
- 2000-01-26 CN CNB008030766A patent/CN1188417C/zh not_active Expired - Fee Related
- 2000-01-26 IL IL14411600A patent/IL144116A0/xx unknown
- 2000-01-26 WO PCT/US2000/001630 patent/WO2000043399A1/fr not_active Application Discontinuation
- 2000-01-26 CA CA002355738A patent/CA2355738A1/fr not_active Abandoned
- 2000-01-26 BR BR0007729-1A patent/BR0007729A/pt not_active IP Right Cessation
- 2000-01-26 HU HU0200013A patent/HUP0200013A3/hu unknown
- 2000-01-26 CZ CZ20012691A patent/CZ20012691A3/cs unknown
- 2000-01-26 PL PL00349874A patent/PL349874A1/xx not_active Application Discontinuation
- 2000-01-26 TR TR2001/02133T patent/TR200102133T2/xx unknown
- 2000-01-26 EP EP00904498A patent/EP1144418A1/fr not_active Withdrawn
- 2000-01-26 JP JP2000594815A patent/JP2002535335A/ja active Pending
- 2000-01-26 SK SK1014-2001A patent/SK10142001A3/sk unknown
- 2000-01-26 EA EA200100813A patent/EA200100813A1/ru unknown
- 2000-01-26 AU AU26246/00A patent/AU2624600A/en not_active Abandoned
- 2000-01-26 ID IDW00200101522A patent/ID29400A/id unknown
-
2001
- 2001-05-25 ZA ZA200104323A patent/ZA200104323B/en unknown
- 2001-07-24 NO NO20013640A patent/NO20013640L/no not_active Application Discontinuation
- 2001-07-26 BG BG105737A patent/BG105737A/xx unknown
-
2002
- 2002-01-10 HK HK02100179.1A patent/HK1038747A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1337965A (zh) | 2002-02-27 |
| CZ20012691A3 (cs) | 2002-06-12 |
| HUP0200013A2 (hu) | 2002-05-29 |
| NO20013640D0 (no) | 2001-07-24 |
| AU2624600A (en) | 2000-08-07 |
| ZA200104323B (en) | 2002-08-26 |
| WO2000043399A1 (fr) | 2000-07-27 |
| NO20013640L (no) | 2001-07-24 |
| SK10142001A3 (sk) | 2002-07-02 |
| IL144116A0 (en) | 2002-05-23 |
| TR200102133T2 (tr) | 2001-12-21 |
| JP2002535335A (ja) | 2002-10-22 |
| HUP0200013A3 (en) | 2002-10-28 |
| BR0007729A (pt) | 2001-10-30 |
| BG105737A (en) | 2002-05-31 |
| HK1038747A1 (zh) | 2002-03-28 |
| EA200100813A1 (ru) | 2003-02-27 |
| CN1188417C (zh) | 2005-02-09 |
| EP1144418A1 (fr) | 2001-10-17 |
| ID29400A (id) | 2001-08-30 |
| PL349874A1 (en) | 2002-09-23 |
| KR20010101649A (ko) | 2001-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4539149A (en) | β-Lactam antibacterial agents | |
| KR20010020181A (ko) | 강력한 β-락타마아제 억제제인 2-옥소-1-아제티딘 술폰산 | |
| JP2642314B2 (ja) | β−ラクタマーゼ阻害剤としての２−β−アルケニルペナムスルホン | |
| EP0508234B1 (fr) | Bêta-lactames | |
| BE898123A (fr) | Nouveaux dérivés d'acides 4-oxo-1, 4-dihydronicotinique, leurs sels, un procédé pour leur production et agents antibactériens les contenant. | |
| US4503040A (en) | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors | |
| KR20050007369A (ko) | 6-알킬리덴 페넴 유도체의 제조방법 | |
| NO802682L (no) | Fremgangsmaate for fremstilling av et synergistisk farmasoeytisk preparat. | |
| US4263302A (en) | Quinolinecarboxylic acid substituted penicillins and pharmaceutical compositions containing the same | |
| US4616038A (en) | Combination of thienamycin-type antibiotics with dipeptidase inhibitors | |
| CA2355738A1 (fr) | Derives de pename sulfone 3,6-disubstitues comme antibacteriens | |
| US6395726B1 (en) | 3,6-disubstituted penam sulfone derivatives | |
| US5686441A (en) | Penam sulfones as β-lactamase inhibitors | |
| EP0001715A2 (fr) | Antibiotiques dérivés d'azétidinone et leurs préparations pharmaceutiques et utilisation | |
| KR870000323B1 (ko) | 6-(아미노메틸)페니실란 1,1-디옥사이드 에스테르의 제조방법 | |
| US4880793A (en) | Combination of thienamycin-type antibiotics with dipeptidase inhibitors | |
| KR880001989B1 (ko) | 펜엠 화합물의 제조방법 | |
| US6489316B2 (en) | 6-(spirocyclopropyl) penicillanic acid 4, 4-dioxides | |
| JPS6118760A (ja) | 抗細菌性７‐オキソ‐４‐チア‐１‐アザ ビシクロ〔３，２，０〕ヘプタ‐２‐エン誘導体 | |
| MXPA01007568A (en) | 3,6-disubstituted penam sulfone derivatives as antibacterials | |
| US4591459A (en) | Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides | |
| EP0066373B1 (fr) | Dérivés de bêta-lactame, procédé de préparation et les compositions les contenant | |
| US5747483A (en) | Penem derivatives, their preparation and pharmaceutical compositions containing them | |
| US5106842A (en) | Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof | |
| JPH04364183A (ja) | フルオロアルキル化カルバペネム中間体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |