CA2354543A1 - Compositions and methods for the treatment of anorectal disorders - Google Patents
Compositions and methods for the treatment of anorectal disorders Download PDFInfo
- Publication number
- CA2354543A1 CA2354543A1 CA002354543A CA2354543A CA2354543A1 CA 2354543 A1 CA2354543 A1 CA 2354543A1 CA 002354543 A CA002354543 A CA 002354543A CA 2354543 A CA2354543 A CA 2354543A CA 2354543 A1 CA2354543 A1 CA 2354543A1
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- composition
- inhibitors
- agent
- treatment
- phosphodiesterase
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11232598P | 1998-12-14 | 1998-12-14 | |
| US60/112,325 | 1998-12-14 | ||
| US13991699P | 1999-06-17 | 1999-06-17 | |
| US60/139,916 | 1999-06-17 | ||
| US60/155,318 | 1999-09-12 | ||
| US15531899P | 1999-09-21 | 1999-09-21 | |
| PCT/US1999/029459 WO2000035434A2 (en) | 1998-12-14 | 1999-12-13 | Compositions and methods for the treatment of anorectal disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2354543A1 true CA2354543A1 (en) | 2000-06-22 |
Family
ID=27381146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002354543A Abandoned CA2354543A1 (en) | 1998-12-14 | 1999-12-13 | Compositions and methods for the treatment of anorectal disorders |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6395736B1 (enExample) |
| EP (1) | EP1143956A3 (enExample) |
| JP (1) | JP2002542147A (enExample) |
| KR (1) | KR20010093828A (enExample) |
| CN (2) | CN1526448A (enExample) |
| AU (1) | AU764921B2 (enExample) |
| BR (1) | BR9916162A (enExample) |
| CA (1) | CA2354543A1 (enExample) |
| CZ (1) | CZ20012113A3 (enExample) |
| HU (1) | HUP0104676A3 (enExample) |
| IL (1) | IL143726A0 (enExample) |
| NO (1) | NO20012916L (enExample) |
| PL (1) | PL348817A1 (enExample) |
| WO (1) | WO2000035434A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011127586A1 (en) * | 2010-04-15 | 2011-10-20 | The Royal Institution For The Advancement Of Learning / Mcgill University | Topical treatments for pain |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| US6627632B2 (en) * | 1998-12-14 | 2003-09-30 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| GB9924636D0 (en) * | 1999-10-18 | 1999-12-22 | Norgine Bv | Laxative preparation |
| HRP20020751B1 (hr) | 2000-02-15 | 2011-01-31 | Sugen | Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze |
| MXPA03000931A (es) * | 2000-07-31 | 2004-08-12 | Cellegy Pharma Inc | Composiciones y metodos para el tratamientos de trastornos anorectales. |
| GB0020588D0 (en) * | 2000-08-21 | 2000-10-11 | Pfizer Ltd | Treatment of wounds |
| AU2000270300A1 (en) * | 2000-09-13 | 2002-03-26 | Isis Innovation Limited | Use of phosphodiesterase inhibitors for the treatment of anorectal disorders |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| DE10118305A1 (de) * | 2001-04-12 | 2002-10-17 | Bayer Ag | Zusammensetzungen zur nasalen Applikation |
| DE10118306A1 (de) * | 2001-04-12 | 2002-10-17 | Bayer Ag | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
| EP2351765A3 (en) * | 2001-07-10 | 2012-02-22 | Lakewood-Amedex, Inc | Oligonucleotide-containing pharmacological compositions and their use |
| WO2003022239A2 (en) * | 2001-09-07 | 2003-03-20 | Western Holdings Llc | Stable water in oil aminophylline emulsions |
| JP2005508953A (ja) | 2001-10-10 | 2005-04-07 | スージェン・インコーポレーテッド | キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体 |
| JP4563679B2 (ja) * | 2001-12-06 | 2010-10-13 | デューク ユニバーシティ | 形成外科における組織弁壊死の予防 |
| WO2003075851A2 (en) * | 2002-03-06 | 2003-09-18 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
| WO2003088961A1 (en) | 2002-04-19 | 2003-10-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders |
| US20040147534A1 (en) * | 2003-01-23 | 2004-07-29 | Foote Mary Ann | Topical composition and method for treating occlusive wounds |
| US6863825B2 (en) | 2003-01-29 | 2005-03-08 | Union Oil Company Of California | Process for removing arsenic from aqueous streams |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| US7799832B2 (en) * | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| DE10352132A1 (de) * | 2003-11-04 | 2005-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem Alpha Agonisten |
| US20060147504A1 (en) * | 2004-12-30 | 2006-07-06 | Bobby Corry | Feminine anti-itch cloth |
| US8252308B2 (en) * | 2005-01-27 | 2012-08-28 | C.B. Fleet Company Inc. | Feminine anti-itch gel |
| WO2006084913A2 (en) * | 2005-02-11 | 2006-08-17 | Nolabs Ab | Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide |
| AU2006334020B2 (en) | 2005-12-30 | 2012-07-05 | Mor Research Applications Ltd. | Device and method for treating the anal sphincter |
| WO2007081521A2 (en) * | 2006-01-05 | 2007-07-19 | Essentialis, Inc. | Salts of potassium atp channel openers and uses thereof |
| US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| NZ575652A (en) * | 2006-08-23 | 2011-08-26 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| KR20090083479A (ko) * | 2006-11-28 | 2009-08-03 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체 |
| US8066874B2 (en) | 2006-12-28 | 2011-11-29 | Molycorp Minerals, Llc | Apparatus for treating a flow of an aqueous solution containing arsenic |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US8349764B2 (en) | 2007-10-31 | 2013-01-08 | Molycorp Minerals, Llc | Composition for treating a fluid |
| US8252087B2 (en) | 2007-10-31 | 2012-08-28 | Molycorp Minerals, Llc | Process and apparatus for treating a gas containing a contaminant |
| WO2010146591A2 (en) | 2009-06-18 | 2010-12-23 | Rdd Pharma Ltd. | Methods and devices for delivery of pharmaceutical agents within orifices of the body |
| US8778969B2 (en) * | 2009-11-07 | 2014-07-15 | Peter H Proctor | Nitrone, nitroso, and nitroxide spintraps and spin labels and their hydroxylamines |
| DK2512479T3 (en) * | 2009-12-18 | 2016-06-06 | Exodos Life Sciences Ltd Partnership | Compositions for the treatment of peripheral vascular disease |
| CN102145004B (zh) * | 2010-02-09 | 2012-03-21 | 鲁南制药集团股份有限公司 | 己酮可可碱在制备预防或治疗功能性便秘的药物中的用途 |
| US9233863B2 (en) | 2011-04-13 | 2016-01-12 | Molycorp Minerals, Llc | Rare earth removal of hydrated and hydroxyl species |
| US9743857B2 (en) | 2011-12-16 | 2017-08-29 | The Regents Of The University Of California | Digital manometry finger-mountable sensor device |
| CN103393690B (zh) * | 2013-08-01 | 2016-05-11 | 南通大学附属医院 | Katp通道开放剂在制备治疗术后疼痛药物中的应用 |
| WO2015112588A1 (en) | 2014-01-22 | 2015-07-30 | Biomimetix Jv, Llc | Methods of treating skin disorders |
| WO2015112586A1 (en) * | 2014-01-22 | 2015-07-30 | Duke University | Methods of treating pruritus |
| MX370462B (es) | 2014-03-07 | 2019-12-13 | Secure Natural Resources Llc | Oxido de cerio (iv) con propiedades de remocion de arsenico excepcionales. |
| RU2595799C1 (ru) * | 2015-05-14 | 2016-08-27 | Светлана Николаевна Суслина | Композиция для лечения анальных трещин в форме крема |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| EP3801460B1 (en) * | 2018-06-01 | 2025-03-12 | Tavanta Therapeutics Hungary Incorporated | Topical amlodipine salts for the treatment of anorectal diseases |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| CA3155812A1 (en) | 2019-11-08 | 2021-05-14 | Cynthia Louise HARDEN | Methods of treating depressive disorders |
| TW202245744A (zh) | 2021-02-09 | 2022-12-01 | 加拿大商再諾製藥公司 | 治療失樂症之方法及用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4117249C2 (de) * | 1991-05-27 | 1998-05-14 | Christian Dr Stief | Linsidomin zur Behandlung erektiler Dysfunktionen |
| GB9119467D0 (en) * | 1991-09-12 | 1991-10-23 | Smithkline Beecham Corp | Chemical compounds |
| US5234947A (en) * | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| ZA941027B (en) * | 1993-02-16 | 1994-11-11 | Smithkline Beecham Corp | Chemical compounds |
| WO1994022460A1 (en) * | 1993-04-05 | 1994-10-13 | University Patents, Inc. | Diagnosis and treatment of erectile dysfunction |
| US5948762A (en) * | 1993-07-16 | 1999-09-07 | Schering Aktiengesellschaft | Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor or a nitric oxide inhibitor |
| WO1995006466A1 (en) * | 1993-09-01 | 1995-03-09 | Koren Laboratories Pty. Limited | Treatment of anorectal disorders |
| PT719145E (pt) * | 1994-05-27 | 2001-01-31 | Cellegy Pharma Inc | Composicao dadora de oxido nitrico para tratamento de desordens anais |
| US5994294A (en) * | 1996-02-02 | 1999-11-30 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
| CA2270118A1 (en) * | 1996-11-01 | 1998-05-14 | Nitromed Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| DE69735552T3 (de) * | 1996-12-23 | 2009-08-13 | S.L.A. Pharma Ag | Pharmazeutische zubereitung zur behandlung der analinkontinenz und analem juckreiz |
| CN1298309A (zh) * | 1998-02-27 | 2001-06-06 | 同步神经元有限责任公司 | 治疗肛门区疼痛的方法及其组合物 |
| ES2205945T3 (es) * | 1998-10-23 | 2004-05-01 | Pfizer Inc. | Pirazolopirimidinonas inhibidoras de gmpc pde5 para el tratamiento de disfunciones sexuales. |
-
1999
- 1999-12-13 US US09/460,306 patent/US6395736B1/en not_active Expired - Fee Related
- 1999-12-13 CA CA002354543A patent/CA2354543A1/en not_active Abandoned
- 1999-12-13 CN CNA200410008292XA patent/CN1526448A/zh active Pending
- 1999-12-13 HU HU0104676A patent/HUP0104676A3/hu unknown
- 1999-12-13 AU AU21763/00A patent/AU764921B2/en not_active Ceased
- 1999-12-13 IL IL14372699A patent/IL143726A0/xx unknown
- 1999-12-13 CN CNB998144304A patent/CN1149983C/zh not_active Expired - Fee Related
- 1999-12-13 PL PL99348817A patent/PL348817A1/xx unknown
- 1999-12-13 WO PCT/US1999/029459 patent/WO2000035434A2/en not_active Ceased
- 1999-12-13 EP EP99966154A patent/EP1143956A3/en not_active Withdrawn
- 1999-12-13 CZ CZ20012113A patent/CZ20012113A3/cs unknown
- 1999-12-13 BR BR9916162-1A patent/BR9916162A/pt not_active Application Discontinuation
- 1999-12-13 JP JP2000587755A patent/JP2002542147A/ja active Pending
- 1999-12-13 KR KR1020017007394A patent/KR20010093828A/ko not_active Ceased
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2001
- 2001-01-23 US US09/769,621 patent/US20010012856A1/en not_active Abandoned
- 2001-06-13 NO NO20012916A patent/NO20012916L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011127586A1 (en) * | 2010-04-15 | 2011-10-20 | The Royal Institution For The Advancement Of Learning / Mcgill University | Topical treatments for pain |
Also Published As
| Publication number | Publication date |
|---|---|
| PL348817A1 (en) | 2002-06-17 |
| CN1149983C (zh) | 2004-05-19 |
| NO20012916L (no) | 2001-08-14 |
| WO2000035434A3 (en) | 2000-11-30 |
| US6395736B1 (en) | 2002-05-28 |
| NO20012916D0 (no) | 2001-06-13 |
| JP2002542147A (ja) | 2002-12-10 |
| US20010012856A1 (en) | 2001-08-09 |
| CZ20012113A3 (cs) | 2001-11-14 |
| HUP0104676A2 (en) | 2002-06-29 |
| AU2176300A (en) | 2000-07-03 |
| AU764921B2 (en) | 2003-09-04 |
| CN1526448A (zh) | 2004-09-08 |
| KR20010093828A (ko) | 2001-10-29 |
| EP1143956A2 (en) | 2001-10-17 |
| HUP0104676A3 (en) | 2005-12-28 |
| WO2000035434A2 (en) | 2000-06-22 |
| EP1143956A3 (en) | 2001-12-12 |
| IL143726A0 (en) | 2002-04-21 |
| BR9916162A (pt) | 2001-09-04 |
| CN1330539A (zh) | 2002-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |