CA2353088A1 - Bis-aminoacides sulfamides contenant un groupe benzyle substitue a l'extremite n-terminale utilises comme inhibiteurs de la protease du vih - Google Patents

Bis-aminoacides sulfamides contenant un groupe benzyle substitue a l'extremite n-terminale utilises comme inhibiteurs de la protease du vih Download PDF

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Publication number
CA2353088A1
CA2353088A1 CA002353088A CA2353088A CA2353088A1 CA 2353088 A1 CA2353088 A1 CA 2353088A1 CA 002353088 A CA002353088 A CA 002353088A CA 2353088 A CA2353088 A CA 2353088A CA 2353088 A1 CA2353088 A1 CA 2353088A1
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CA
Canada
Prior art keywords
compound
compound according
mmol
formula
hiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002353088A
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English (en)
Inventor
Robert F. Kaltenbach
George L. Trainor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2353088A1 publication Critical patent/CA2353088A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne, de manière générale, des bis-aminoacides sulfamides renfermant des benzylamines substituées de formule 1, ou des formes ou des mélanges stéréoisomères de ceux-ci ou leurs formes de sels pharmaceutiquement acceptables, lesquels composés sont utilisés comme inhibiteurs de la protéase du VIH. L'invention concerne également des compositions pharmaceutiques et des trousses de diagnostic les comprenant, des procédés d'utilisation de celles-ci dans le traitement d'infections virales ou comme étalons ou réactifs de bioanalyse, ainsi que leurs intermédiaires et procédés de fabrication.
CA002353088A 1999-01-13 2000-01-13 Bis-aminoacides sulfamides contenant un groupe benzyle substitue a l'extremite n-terminale utilises comme inhibiteurs de la protease du vih Abandoned CA2353088A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
US60/115,746 1999-01-13
PCT/US2000/000820 WO2000042060A1 (fr) 1999-01-13 2000-01-13 Bis-aminoacides sulfamides contenant un groupe benzyle substitue a l'extremite n-terminale utilises comme inhibiteurs de la protease du vih

Publications (1)

Publication Number Publication Date
CA2353088A1 true CA2353088A1 (fr) 2000-07-20

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002353088A Abandoned CA2353088A1 (fr) 1999-01-13 2000-01-13 Bis-aminoacides sulfamides contenant un groupe benzyle substitue a l'extremite n-terminale utilises comme inhibiteurs de la protease du vih

Country Status (15)

Country Link
EP (1) EP1140983A1 (fr)
JP (1) JP2002536298A (fr)
KR (1) KR20010101478A (fr)
CN (1) CN1336934A (fr)
AU (1) AU2725700A (fr)
BR (1) BR0007854A (fr)
CA (1) CA2353088A1 (fr)
CZ (1) CZ20012435A3 (fr)
HU (1) HUP0105235A3 (fr)
IL (1) IL143763A0 (fr)
NO (1) NO20013338L (fr)
PL (1) PL349774A1 (fr)
SK (1) SK9522001A3 (fr)
TR (1) TR200102033T2 (fr)
WO (1) WO2000042060A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1188766A1 (fr) * 1995-03-10 2002-03-20 G.D. Searle & Co. Hydroxyethylamino sulfonamide de bis-aminoacide comme inhibiteurs de proteases de retrovirus
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor
US6617310B2 (en) 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE172717T1 (de) * 1992-08-25 1998-11-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
EP0715618B1 (fr) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
HUP0105235A3 (en) 2002-08-28
NO20013338L (no) 2001-09-13
IL143763A0 (en) 2002-04-21
TR200102033T2 (tr) 2001-12-21
CN1336934A (zh) 2002-02-20
PL349774A1 (en) 2002-09-09
EP1140983A1 (fr) 2001-10-10
SK9522001A3 (en) 2002-03-05
KR20010101478A (ko) 2001-11-14
WO2000042060A1 (fr) 2000-07-20
CZ20012435A3 (cs) 2002-02-13
BR0007854A (pt) 2002-01-15
AU2725700A (en) 2000-08-01
HUP0105235A2 (hu) 2002-04-29
JP2002536298A (ja) 2002-10-29
NO20013338D0 (no) 2001-07-05

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Legal Events

Date Code Title Description
FZDE Discontinued