CA2351365A1 - Proteines d'interaction de canaux potassiques (pcip) et procedes de leur utilisation - Google Patents

Proteines d'interaction de canaux potassiques (pcip) et procedes de leur utilisation Download PDF

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Publication number
CA2351365A1
CA2351365A1 CA002351365A CA2351365A CA2351365A1 CA 2351365 A1 CA2351365 A1 CA 2351365A1 CA 002351365 A CA002351365 A CA 002351365A CA 2351365 A CA2351365 A CA 2351365A CA 2351365 A1 CA2351365 A1 CA 2351365A1
Authority
CA
Canada
Prior art keywords
seq
pcip
nucleic acid
polypeptide
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002351365A
Other languages
English (en)
Inventor
Kenneth Rhodes
Maria Betty
Huai-Ping Ling
Wenqian An
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Millennium Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/298,731 external-priority patent/US6369197B1/en
Priority claimed from US09/350,874 external-priority patent/US20020019020A1/en
Priority claimed from US09/399,913 external-priority patent/US6361971B1/en
Priority claimed from US09/400,492 external-priority patent/US7115381B1/en
Application filed by Individual filed Critical Individual
Publication of CA2351365A1 publication Critical patent/CA2351365A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des molécules isolées d'acides nucléiques désignées "molécules d'acides nucléiques PCIP" codant pour les protéines qui lient les canaux potassiques et modulent les activités à médiation par canaux potassiques. L'invention concerne aussi des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinants contenant des molécules d'acides nucléiques PCIP, des cellules hôtes dans lesquelles on a introduit des vecteurs d'expression et, enfin, des animaux transgéniques non humaines dans lesquels on a introduit ou rompu un gène PCIP. L'invention concerne en outre des protéines PCIP isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-PCIP. Elle concerne enfin des procédés diagnostiques utilisant les compositions de l'invention.
CA002351365A 1998-11-20 1999-11-19 Proteines d'interaction de canaux potassiques (pcip) et procedes de leur utilisation Abandoned CA2351365A1 (fr)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US10933398P 1998-11-20 1998-11-20
US60/109,333 1998-11-20
US11003398P 1998-11-25 1998-11-25
US60/110,033 1998-11-25
US11027798P 1998-11-30 1998-11-30
US60/110,277 1998-11-30
US09/298,731 1999-04-23
US09/298,731 US6369197B1 (en) 1998-11-20 1999-04-23 Potassium channel interactors and uses therefor
US09/350,614 US6689581B1 (en) 1998-11-20 1999-07-09 Potassium channel interactors and uses therefor
US09/350,614 1999-07-09
US09/350,874 US20020019020A1 (en) 1998-11-20 1999-07-09 Methods for treating cardiovascular disorders
US09/350,874 1999-07-09
US09/400,492 1999-09-21
US09/399,913 1999-09-21
US09/399,913 US6361971B1 (en) 1998-11-20 1999-09-21 Nucleic acid molecules encoding potassium channel interactors and uses therefor
US09/400,492 US7115381B1 (en) 1998-11-20 1999-09-21 Methods for treating cardiovascular disorders
PCT/US1999/027428 WO2000031133A2 (fr) 1998-11-20 1999-11-19 Proteines d'interaction de canaux potassiques (pcip) et procedes de leur utilisation

Publications (1)

Publication Number Publication Date
CA2351365A1 true CA2351365A1 (fr) 2000-06-02

Family

ID=27574798

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002351365A Abandoned CA2351365A1 (fr) 1998-11-20 1999-11-19 Proteines d'interaction de canaux potassiques (pcip) et procedes de leur utilisation

Country Status (12)

Country Link
EP (1) EP1131349A2 (fr)
JP (1) JP2002530104A (fr)
CN (1) CN1346368A (fr)
AU (1) AU775713B2 (fr)
BR (1) BR9915513A (fr)
CA (1) CA2351365A1 (fr)
CZ (1) CZ20011764A3 (fr)
IL (1) IL143148A0 (fr)
MX (1) MXPA01004903A (fr)
NO (1) NO20012471L (fr)
NZ (1) NZ512332A (fr)
WO (1) WO2000031133A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369197B1 (en) 1998-11-20 2002-04-09 Millennium Pharmaceuticals, Inc. Potassium channel interactors and uses therefor
US7078481B1 (en) 1998-11-20 2006-07-18 Wyeth Potassium channel interactors and uses therefor
BR0114383A (pt) * 2000-09-27 2005-04-12 Millennium Pharm Inc Interatuadores de canais de potássio e aplicações dos mesmos
EP2353014A2 (fr) * 2008-11-06 2011-08-10 Basf Se Test de criblage ea pour insecticides
GB201906482D0 (en) * 2019-05-08 2019-06-19 Evox Therapeutics Ltd Exosome comprising stabilized RNA therapeutics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4758997A (en) * 1996-10-17 1998-05-11 Nps Pharmaceuticals, Inc. Potassium channel blocking compounds and their use
US6117989A (en) * 1998-03-26 2000-09-12 Incyte Pharmaceuticals, Inc. Human calcium-binding proteins

Also Published As

Publication number Publication date
CN1346368A (zh) 2002-04-24
MXPA01004903A (es) 2003-03-10
IL143148A0 (en) 2002-04-21
NO20012471L (no) 2001-07-18
EP1131349A2 (fr) 2001-09-12
WO2000031133A2 (fr) 2000-06-02
WO2000031133A3 (fr) 2000-10-05
JP2002530104A (ja) 2002-09-17
BR9915513A (pt) 2002-02-05
NO20012471D0 (no) 2001-05-18
AU775713B2 (en) 2004-08-12
NZ512332A (en) 2004-02-27
CZ20011764A3 (cs) 2002-01-16
AU1479700A (en) 2000-06-13

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued