CA2346131C - Method for improving the pharmacokinetics of tipranavir - Google Patents
Method for improving the pharmacokinetics of tipranavir Download PDFInfo
- Publication number
- CA2346131C CA2346131C CA2346131A CA2346131A CA2346131C CA 2346131 C CA2346131 C CA 2346131C CA 2346131 A CA2346131 A CA 2346131A CA 2346131 A CA2346131 A CA 2346131A CA 2346131 C CA2346131 C CA 2346131C
- Authority
- CA
- Canada
- Prior art keywords
- tipranavir
- ritonavir
- bid
- concentrations
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10696398P | 1998-11-04 | 1998-11-04 | |
| US60/106,963 | 1998-11-04 | ||
| PCT/US1999/021469 WO2000025784A1 (en) | 1998-11-04 | 1999-10-29 | Method for improving the pharmacokinetics of tipranavir |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2346131A1 CA2346131A1 (en) | 2000-05-11 |
| CA2346131C true CA2346131C (en) | 2013-01-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2346131A Expired - Lifetime CA2346131C (en) | 1998-11-04 | 1999-10-29 | Method for improving the pharmacokinetics of tipranavir |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6147095A (enExample) |
| EP (1) | EP1126847A1 (enExample) |
| JP (1) | JP2002528502A (enExample) |
| CN (1) | CN1154491C (enExample) |
| AU (1) | AU762349B2 (enExample) |
| BR (1) | BR9914940A (enExample) |
| CA (1) | CA2346131C (enExample) |
| CO (1) | CO5160321A1 (enExample) |
| HK (1) | HK1040625B (enExample) |
| MY (1) | MY118526A (enExample) |
| PE (1) | PE20001296A1 (enExample) |
| TW (1) | TW580387B (enExample) |
| WO (1) | WO2000025784A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB9815567D0 (en) * | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
| ATE381922T1 (de) * | 2000-10-31 | 2008-01-15 | Boehringer Ingelheim Pharma | Perorale, selbst-emulgierende darreichungsformen von pyranon-proteaseinhibitoren |
| US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
| DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
| US20040197321A1 (en) * | 2002-03-19 | 2004-10-07 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| US20030180279A1 (en) * | 2002-03-19 | 2003-09-25 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| EP1575595A1 (en) * | 2002-12-16 | 2005-09-21 | Boehringer Ingelheim International GmbH | Use of a combination containing a non-nucleoside reverse transcriptase inhibitor (nnrti) with an inhibitor of cytochrome p450, such as protease inhibitors |
| US20050020517A1 (en) * | 2002-12-16 | 2005-01-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Treatment of HIV infection through combined administration of tipranavir and capravirine |
| WO2004087139A1 (en) * | 2003-03-27 | 2004-10-14 | Boehringer Ingelheim International Gmbh | Antiviral combination of tipranavir and a further antiretroviral compound |
| AR045841A1 (es) * | 2004-09-28 | 2005-11-16 | Richmond Sa Com Ind Y Financie | Una composicion farmaceutica solida que comprende al tiazolil metil ester del acido [5s-(5r*, 8r*, 10r*,11r*)] -10- hidroxi-2- metil-5-(1-metiletil)-1-[2-(1-metiletil)-4-tiazolil]-3,6-dioxo-8,11-bis(fenilmetil)-2,4,7,12- tetraazatridecan-13-oico y un procedimiento para prepararla. |
| CA2583187A1 (en) * | 2004-11-08 | 2006-05-18 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and etravirine |
| JP2008520672A (ja) * | 2004-11-16 | 2008-06-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビルとダルナビルの共投与によるｈｉｖ感染症の治療方法 |
| US20060128733A1 (en) * | 2004-11-19 | 2006-06-15 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and reverset |
| US20060122220A1 (en) * | 2004-11-19 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and UK-427,857 |
| CA2585663A1 (en) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and sch-417690 |
| JP2008521898A (ja) * | 2004-12-01 | 2008-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビル及びｇｗ８７３１４０を共に投与することを含むｈｉｖ感染症の治療方法 |
| US20060142344A1 (en) * | 2004-12-01 | 2006-06-29 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and GW695634 |
| KR101518079B1 (ko) | 2007-03-12 | 2015-05-06 | 넥타르 테라퓨틱스 | 올리고머-프로테아제 억제제 컨주게이트 |
| EP2262538B1 (en) * | 2008-03-12 | 2014-12-10 | Nektar Therapeutics | Oligomer-amino acid conjugate |
| US20100021505A1 (en) * | 2008-07-28 | 2010-01-28 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
| BR112012024522A2 (pt) * | 2010-04-02 | 2017-08-08 | Phivco 1 Llc | combinação, uso de uma combinação, composição farmacêutica, forma de dosagem única , kit, e, método para tratar um distúrbio |
| CN104160274A (zh) * | 2011-05-30 | 2014-11-19 | 奥德特里克公司 | 通过照护点药物动力学曲线分析进行治疗药物监测和投配的方法与组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5608085A (en) * | 1995-02-27 | 1997-03-04 | The University Of Tennessee Research Corporation | Synthesis of optically active calanolides A and B and enantiomers and related compounds |
| US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US5932570A (en) * | 1996-11-08 | 1999-08-03 | Dupont Pharmaceuticals Company | 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors |
| ZA9710071B (en) * | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
-
1999
- 1999-10-29 JP JP2000579225A patent/JP2002528502A/ja active Pending
- 1999-10-29 WO PCT/US1999/021469 patent/WO2000025784A1/en not_active Ceased
- 1999-10-29 US US09/430,742 patent/US6147095A/en not_active Expired - Lifetime
- 1999-10-29 EP EP99971319A patent/EP1126847A1/en active Pending
- 1999-10-29 BR BR9914940-0A patent/BR9914940A/pt not_active Application Discontinuation
- 1999-10-29 HK HK02102194.8A patent/HK1040625B/zh not_active IP Right Cessation
- 1999-10-29 CN CNB998123587A patent/CN1154491C/zh not_active Expired - Lifetime
- 1999-10-29 CA CA2346131A patent/CA2346131C/en not_active Expired - Lifetime
- 1999-10-29 AU AU14404/00A patent/AU762349B2/en not_active Expired
- 1999-11-03 PE PE1999001100A patent/PE20001296A1/es not_active Application Discontinuation
- 1999-11-04 CO CO99069669A patent/CO5160321A1/es unknown
- 1999-11-04 MY MYPI99004794A patent/MY118526A/en unknown
- 1999-11-04 TW TW088119229A patent/TW580387B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MY118526A (en) | 2004-11-30 |
| PE20001296A1 (es) | 2000-11-23 |
| US6147095A (en) | 2000-11-14 |
| CO5160321A1 (es) | 2002-05-30 |
| CN1324237A (zh) | 2001-11-28 |
| AU762349B2 (en) | 2003-06-26 |
| JP2002528502A (ja) | 2002-09-03 |
| EP1126847A1 (en) | 2001-08-29 |
| HK1040625B (zh) | 2005-04-01 |
| TW580387B (en) | 2004-03-21 |
| AU1440400A (en) | 2000-05-22 |
| WO2000025784A1 (en) | 2000-05-11 |
| HK1040625A1 (en) | 2002-06-21 |
| CN1154491C (zh) | 2004-06-23 |
| CA2346131A1 (en) | 2000-05-11 |
| BR9914940A (pt) | 2001-07-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20191029 |