CA2343289A1 - Regulation de l'expression d'oncogene her2/neu a l'aide de polyamides synthetiques - Google Patents

Regulation de l'expression d'oncogene her2/neu a l'aide de polyamides synthetiques Download PDF

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Publication number
CA2343289A1
CA2343289A1 CA002343289A CA2343289A CA2343289A1 CA 2343289 A1 CA2343289 A1 CA 2343289A1 CA 002343289 A CA002343289 A CA 002343289A CA 2343289 A CA2343289 A CA 2343289A CA 2343289 A1 CA2343289 A1 CA 2343289A1
Authority
CA
Canada
Prior art keywords
polyamide
correspond
composition
pair
polyamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002343289A
Other languages
English (en)
Inventor
Peter B. Dervan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2343289A1 publication Critical patent/CA2343289A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des méthodes et des compositions comprenant des polyamides pouvant se lier au sillon mineur d'ADN double brin destinées à inhiber ou à réduire la transcription et l'expression de gène. Ces polyamides comprennent au moins quatre paires de résidus carboxamides aromatiques choisis afin de contacter et/ou de se lier spécifiquement à la séquence de nucléotides d'une cible ADN à double brin dans la région promoteur du gène de la cible. Ces méthodes, compositions et polyamides sont destinés à l'inhibition de la transcription et de l'expression d'oncogène aussi bien qu'au traitement de cancer.
CA002343289A 1998-09-11 1999-09-10 Regulation de l'expression d'oncogene her2/neu a l'aide de polyamides synthetiques Abandoned CA2343289A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9990698P 1998-09-11 1998-09-11
US60/099,906 1998-09-11
PCT/US1999/020971 WO2000015242A1 (fr) 1998-09-11 1999-09-10 REGULATION DE L'EXPRESSION D'ONCOGENE HER2/neu A L'AIDE DE POLYAMIDES SYNTHETIQUES

Publications (1)

Publication Number Publication Date
CA2343289A1 true CA2343289A1 (fr) 2000-03-23

Family

ID=22277188

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002343289A Abandoned CA2343289A1 (fr) 1998-09-11 1999-09-10 Regulation de l'expression d'oncogene her2/neu a l'aide de polyamides synthetiques
CA002344654A Abandoned CA2344654A1 (fr) 1998-09-11 1999-09-10 Regulation de l'expression oncogene de her2/neu par des polyamines synt hetiques

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002344654A Abandoned CA2344654A1 (fr) 1998-09-11 1999-09-10 Regulation de l'expression oncogene de her2/neu par des polyamines synt hetiques

Country Status (5)

Country Link
EP (2) EP1112080A4 (fr)
JP (2) JP2002524501A (fr)
AU (2) AU768405B2 (fr)
CA (2) CA2343289A1 (fr)
WO (2) WO2000015209A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1762614A3 (fr) * 2000-07-21 2007-05-30 Research Corporation Technologies, Inc. Promoteurs spécifiques de tumeur
US7122626B2 (en) 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
AU2002312371A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Aryl-benzimidazole compounds having antiinfective activity
EP1470119A4 (fr) 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc Composes benzothiophene presentant une activite anti-infectieuse
WO2002101007A2 (fr) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc Composes benzamides anti-pathogenes
US6777425B2 (en) 2001-06-13 2004-08-17 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
DE60326735D1 (de) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
JP3792655B2 (ja) 2003-01-20 2006-07-05 日本電気株式会社 新規な癌遺伝子、該癌遺伝子由来の組換えタンパク質、およびそれらの用途
JP2006022063A (ja) * 2004-07-09 2006-01-26 Univ Nihon Ｌｏｘ−１遺伝子発現抑制剤
US10307401B2 (en) * 2016-08-29 2019-06-04 California Institute Of Technology Compositions and methods for treatment of prostate cancer
US10723716B2 (en) 2016-12-21 2020-07-28 New York University Alpha-helix mimetics as modulators of Abeta self-assembly

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2280806A1 (fr) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition de la transcription de genes par des ligands de polyamide se fixant a l'adn

Also Published As

Publication number Publication date
EP1162961A2 (fr) 2001-12-19
JP2002524501A (ja) 2002-08-06
AU768405B2 (en) 2003-12-11
CA2344654A1 (fr) 2000-03-23
AU6496599A (en) 2000-04-03
WO2000015242A1 (fr) 2000-03-23
JP2002524525A (ja) 2002-08-06
EP1112080A4 (fr) 2002-10-24
WO2000015209A2 (fr) 2000-03-23
EP1112080A1 (fr) 2001-07-04
WO2000015209A3 (fr) 2000-05-25
AU6034199A (en) 2000-04-03

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