CA2343099C - Compositions de hkis et procedes d'utilisation correspondants - Google Patents

Compositions de hkis et procedes d'utilisation correspondants Download PDF

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Publication number
CA2343099C
CA2343099C CA002343099A CA2343099A CA2343099C CA 2343099 C CA2343099 C CA 2343099C CA 002343099 A CA002343099 A CA 002343099A CA 2343099 A CA2343099 A CA 2343099A CA 2343099 C CA2343099 C CA 2343099C
Authority
CA
Canada
Prior art keywords
hkis
nucleic acid
protein
seq
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002343099A
Other languages
English (en)
Other versions
CA2343099A1 (fr
Inventor
Gary J. Nabel
Elizabeth G. Nabel
Manfred Boehm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of CA2343099A1 publication Critical patent/CA2343099A1/fr
Application granted granted Critical
Publication of CA2343099C publication Critical patent/CA2343099C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle composition et des procédés pour modifier la prolifération d'une cellule, et notamment des polypeptides de hKIS de type sauvage ou mutants ainsi que des inhibiteurs de kinase dépendante des cyclines, qui contiennent des mutations empêchant leur inhibition par des kinases de sérine / de thréonine.
CA002343099A 1998-08-21 1999-08-20 Compositions de hkis et procedes d'utilisation correspondants Expired - Fee Related CA2343099C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9771098P 1998-08-21 1998-08-21
US60/097,710 1998-08-21
PCT/US1999/018903 WO2000011165A1 (fr) 1998-08-21 1999-08-20 COMPOSITIONS DE hKIS ET PROCEDES D'UTILISATION CORRESPONDANTS

Publications (2)

Publication Number Publication Date
CA2343099A1 CA2343099A1 (fr) 2000-03-02
CA2343099C true CA2343099C (fr) 2006-11-14

Family

ID=22264764

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343099A Expired - Fee Related CA2343099C (fr) 1998-08-21 1999-08-20 Compositions de hkis et procedes d'utilisation correspondants

Country Status (4)

Country Link
EP (1) EP1104463A1 (fr)
AU (1) AU5572599A (fr)
CA (1) CA2343099C (fr)
WO (1) WO2000011165A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2253220T3 (es) 1999-04-15 2006-06-01 Calgene Llc Secuencias de acido nucleico de proteinas implicadas en la sintesis de tocoferol.
AU2001245974A1 (en) 2000-03-24 2001-10-08 Millennium Pharmaceuticals, Inc. 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
DE60140312D1 (en) 2000-08-07 2009-12-10 Monsanto Technology Llc Am methyl-d-erythriol phosphat reaktionsweg beteiligte gene
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
DE60230608D1 (de) 2001-05-09 2009-02-12 Monsanto Technology Llc Tyra-gene und ihre verwendung
EP1427832A4 (fr) 2001-08-17 2006-09-06 Monsanto Technology Llc Genes de methyltransferase et leurs utilisations
AU2002342114B2 (en) 2001-10-25 2008-07-31 Monsanto Technology Llc Aromatic methyltransferases and uses thereof
BRPI0308740B1 (pt) 2002-03-19 2018-11-21 Monsanto Technology Llc molécula de ácido nucléico codificando uma homogentisato prenil transferase (“hpt”) e método de produzir planta tendo semente com nível de tocoferol aumentado
US7230165B2 (en) 2002-08-05 2007-06-12 Monsanto Technology Llc Tocopherol biosynthesis related genes and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682728B1 (en) * 1993-10-13 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Efficient and selective adenoviral-mediated gene transfer into vascular neointima

Also Published As

Publication number Publication date
EP1104463A1 (fr) 2001-06-06
WO2000011165A9 (fr) 2000-06-22
CA2343099A1 (fr) 2000-03-02
WO2000011165A1 (fr) 2000-03-02
AU5572599A (en) 2000-03-14

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