CA2339192C - Treatment of addiction and addiction-related behavior - Google Patents
Treatment of addiction and addiction-related behavior Download PDFInfo
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- CA2339192C CA2339192C CA002339192A CA2339192A CA2339192C CA 2339192 C CA2339192 C CA 2339192C CA 002339192 A CA002339192 A CA 002339192A CA 2339192 A CA2339192 A CA 2339192A CA 2339192 C CA2339192 C CA 2339192C
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- addiction
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| US09/189,166 US6828349B1 (en) | 1998-08-05 | 1998-11-09 | Treatment of addiction and addiction-related behavior |
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| US09/209,952 US6541520B1 (en) | 1998-08-05 | 1998-12-11 | Treatment of addiction and addiction-related behavior |
| US09/209,952 | 1998-12-11 | ||
| PCT/US1999/017220 WO2000007583A2 (en) | 1998-08-05 | 1999-08-05 | Treatment of addiction and addiction-related behavior |
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| CA2339192A1 CA2339192A1 (en) | 2000-02-17 |
| CA2339192C true CA2339192C (en) | 2009-12-22 |
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| US6890951B2 (en) * | 1998-08-05 | 2005-05-10 | Brookhaven Science Associates Llc | Treatment of addiction and addiction-related behavior |
| WO2000010554A2 (en) * | 1998-08-25 | 2000-03-02 | Sepracor Inc. | Methods and compositions employing optically pure s(+) vigabatrin |
| MXPA01004015A (es) * | 1998-10-20 | 2003-03-10 | Johnson & Johnson | Derivados anticonvulsivos utiles para el tratamiento de la dependencia, adiccion y abuso del alcohol. |
| ES2238999T3 (es) | 1999-02-24 | 2005-09-16 | University Of Cincinnati | Uso de derivados de sulfamato para tratar trastornos en el control de los impulsos. |
| WO2000066108A2 (en) * | 1999-04-30 | 2000-11-09 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating cocaine dependency |
| IT1313585B1 (it) * | 1999-07-30 | 2002-09-09 | Neuroscienze S C A R L | Uso di agonisti dei recettori gabab per la terapia di mantenimentodell'astinenza da nicotina in soggetti nicotino-dipendenti. |
| US6395783B1 (en) * | 2000-10-23 | 2002-05-28 | Brookhaven Science Associates, Llc | Treatment of PCP addiction and PCP addiction-related behavior |
| US20050192271A1 (en) * | 2003-07-15 | 2005-09-01 | Hythiam, Inc. | Use of selective chloride channel modulators to treat alcohol and/or stimulant substance abuse |
| US20020187996A1 (en) * | 2001-05-14 | 2002-12-12 | Dewey Stephen L. | Prevention of addiction in pain management |
| US6462084B1 (en) * | 2001-05-14 | 2002-10-08 | Brookhaven Science Associates, Llc | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
| UA78211C2 (en) * | 2001-07-09 | 2007-03-15 | Ortho Mcneil Pharm Inc | Salts of fructopyranose derivatives as anticonvulsant |
| US7041650B2 (en) | 2001-07-09 | 2006-05-09 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivative salts |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| US7822470B2 (en) * | 2001-10-11 | 2010-10-26 | Osypka Medical Gmbh | Method for determining the left-ventricular ejection time TLVE of a heart of a subject |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
| US20050025791A1 (en) | 2002-06-21 | 2005-02-03 | Julius Remenar | Pharmaceutical compositions with improved dissolution |
| US20090088443A1 (en) * | 2002-02-15 | 2009-04-02 | Julius Remenar | Novel crystalline forms of conazoles and methods of making and using the same |
| US6559293B1 (en) | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| JP4906233B2 (ja) * | 2002-03-01 | 2012-03-28 | ユニバーシティー オブ サウス フロリダ | 少なくとも１種の有効薬剤成分を含有する多構成要素固相 |
| US6797707B2 (en) * | 2002-03-29 | 2004-09-28 | University Of Florida | Antagonists of RF-amide neuropeptides |
| US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7201920B2 (en) * | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
| HUE037643T2 (hu) | 2004-06-12 | 2018-09-28 | Collegium Pharmaceutical Inc | Visszaélésre nem alkalmas gyógyszerkészítmények |
| MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| US20060110327A1 (en) * | 2004-11-24 | 2006-05-25 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| US20060177380A1 (en) * | 2004-11-24 | 2006-08-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| US20070231268A1 (en) * | 2004-11-24 | 2007-10-04 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| US20080152595A1 (en) * | 2004-11-24 | 2008-06-26 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| AR055792A1 (es) * | 2005-05-17 | 2007-09-05 | Wm Internat Ltd | Aparato y metodo para la estabilizacion no quimica de bio-solidos |
| WO2006127184A1 (en) | 2005-05-20 | 2006-11-30 | Janssen Pharmaceutica N.V. | Process for preparation of sulfamide derivatives |
| AU2006287378A1 (en) * | 2005-09-07 | 2007-03-15 | Braincells, Inc. | Modulation of neurogenesis by HDac inhibition |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8492431B2 (en) | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
| DE102006016990A1 (de) * | 2006-04-11 | 2007-10-18 | Hermann, Holger Lars, Dr. | Verwendung von Baclofen und Baclofen-Derivaten zur Entzugs- und/oder Substitutionsbehandlung bei Abhängigkeit von GHB und/oder GHB-Analogen |
| EP2026790A2 (en) | 2006-05-19 | 2009-02-25 | Janssen Pharmaceutica, N.V. | Co-therapy for the treatment of epilepsy and related disorders |
| US20100021570A1 (en) * | 2006-06-21 | 2010-01-28 | Harlan Clayton Bieley | Smoking Cessation Treatment By Reducing Nicotine Cravings, Apetite Suppression, And Altering The Perceived Taste Of Tobacco Smoke |
| US20080103111A1 (en) * | 2006-06-21 | 2008-05-01 | Harlan Clayton Bieley | Smoking Cessation Treatment with Appetite Suppression |
| DK2061458T3 (en) * | 2006-09-15 | 2015-03-09 | Univ Minnesota | Topiramate compositions and methods for their use |
| US20090239942A1 (en) * | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
| US20090270438A1 (en) * | 2006-10-18 | 2009-10-29 | Clive Booles | Novel compositions and formulations |
| WO2008090736A1 (ja) * | 2007-01-23 | 2008-07-31 | Nagoya City University | アルツハイマー型認知症の予防及び治療のための医薬 |
| AU2008283903B2 (en) | 2007-08-06 | 2014-01-16 | Biotie Therapies, Inc | Methods for treating dependence |
| CA2702680A1 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| WO2010008776A2 (en) | 2008-06-23 | 2010-01-21 | Janssen Pharmaceutica Nv | Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems |
| US8815939B2 (en) | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| WO2011041414A1 (en) * | 2009-09-30 | 2011-04-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
| CN102573821A (zh) * | 2009-09-30 | 2012-07-11 | 哈兰·克莱顿·比利 | 保持体重的戒烟法及营养补充剂 |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| WO2011106692A2 (en) * | 2010-02-25 | 2011-09-01 | Northwestern University | Methods of using (1s, 3s) -3-amino-4-difluoromethylenyl-1-cyclopentanoic acid |
| US20120046232A1 (en) * | 2010-06-22 | 2012-02-23 | Medical University Of South Carolina | Compositions and methods for reducing relapse of addictive behavior |
| US8808740B2 (en) | 2010-12-22 | 2014-08-19 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| US20140072935A1 (en) * | 2012-09-07 | 2014-03-13 | Tina M. Herron | Method of Regulating Caloric Intake |
| MX392839B (es) | 2012-11-30 | 2025-03-24 | Acura Pharmaceuticals Inc | Liberacion autorregulada de ingrediente farmaceutico activo. |
| PE20151301A1 (es) | 2013-02-05 | 2015-09-16 | Purdue Pharma Lp | Formulaciones farmaceuticas resistentes a la manipulacion indebida |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| JP6510628B2 (ja) | 2014-03-26 | 2019-05-15 | サン・ファーマ・アドバンスト・リサーチ・カンパニー・リミテッド | 乱用防止即時放出性被覆リザーバ固体剤形 |
| US9662392B2 (en) | 2014-06-03 | 2017-05-30 | Pop Test Abuse Deterrent Technology Llc | Drug device configured for wireless communication |
| US11103581B2 (en) | 2015-08-31 | 2021-08-31 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
| WO2017222575A1 (en) | 2016-06-23 | 2017-12-28 | Collegium Pharmaceutical, Inc. | Process of making more stable abuse-deterrent oral formulations |
| CN114903006B (zh) * | 2021-02-09 | 2024-08-02 | 中国科学院脑科学与智能技术卓越创新中心 | 一种非人灵长类动物物质成瘾模型的构建方法与应用 |
| EP4334282A4 (en) * | 2021-05-05 | 2025-03-19 | Mind Medicine, Inc. | ENANTIOMERS OF MDMA |
| CN115386421A (zh) * | 2022-06-23 | 2022-11-25 | 江苏华熙益能生物科技有限公司 | 烟叶用香精、制备方法及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639607A (en) | 1970-11-02 | 1972-02-01 | Jack E Phillips | Method for treating the tobacco smoking habit |
| US3960927A (en) | 1975-03-18 | 1976-06-01 | Richardson-Merrell Inc. | Olefinic derivatives of amino acids |
| NZ194348A (en) * | 1979-07-26 | 1982-09-14 | Merrell Toraude & Co | Fluorinated methyl-beta-alanine derivatives and pharmaceutical compositions |
| GB2133002B (en) | 1982-12-30 | 1986-01-29 | Merrell Toraude & Co | Process for preparing 4-amino-5-hexenoic acid |
| GB8311804D0 (en) | 1983-04-29 | 1983-06-02 | Merrell Toraude & Co | Treatment of seizure disorders and pharmaceutical compositions |
| US4595697A (en) | 1984-03-28 | 1986-06-17 | Merrell Dow Pharmaceuticals Inc. | Treatment of seizure disorders and pharmaceutical compositions useful therein |
| US5189064A (en) * | 1985-07-22 | 1993-02-23 | Matrix Technologies, Inc. | Treatment of cocaine addiction |
| EP0381696B1 (en) | 1987-10-07 | 1993-07-28 | Matrix Technologies, Inc. | Pharmaceutical composition for the treatment of cocaine addiction |
| EP0509180A1 (en) * | 1991-04-18 | 1992-10-21 | Merrell Dow Pharmaceuticals Inc. | Use of GABA-T inhibitors for the treatment of schizophrenia and phencyclidine intoxication |
| US5189026A (en) * | 1991-06-07 | 1993-02-23 | Fractal Laboratories, Inc. | Treatment of human diseases involving dysregulation or dysfunction of the nervous system |
| GB9125615D0 (en) * | 1991-12-02 | 1992-01-29 | Wyeth John & Brother Ltd | Amines |
| US5332736A (en) * | 1993-11-01 | 1994-07-26 | Ortho Pharmaceutical Corporation | Anti-convulsant aroyl aminoacylpyrroles |
| US5824684A (en) * | 1997-02-21 | 1998-10-20 | Synapse Pharmaceuticals International, Inc. | Method for treating drug and alcohol addiction |
| US5760049A (en) * | 1997-02-21 | 1998-06-02 | Synapse Pharmaceuticals International, Inc. | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use |
| HUP0100115A2 (hu) | 1997-10-28 | 2001-06-28 | Schering Corp. | Eljárás kóros vágy csökkentésére emlősökben |
| MXPA01004015A (es) | 1998-10-20 | 2003-03-10 | Johnson & Johnson | Derivados anticonvulsivos utiles para el tratamiento de la dependencia, adiccion y abuso del alcohol. |
| ES2238999T3 (es) | 1999-02-24 | 2005-09-16 | University Of Cincinnati | Uso de derivados de sulfamato para tratar trastornos en el control de los impulsos. |
| WO2000066108A2 (en) | 1999-04-30 | 2000-11-09 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating cocaine dependency |
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- 1999-08-05 ID IDW20010504A patent/ID28916A/id unknown
- 1999-08-05 DK DK99941982T patent/DK1102583T3/da active
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- 1999-08-05 HU HU0103377A patent/HUP0103377A3/hu unknown
- 1999-08-05 EP EP99941982A patent/EP1102583B1/en not_active Expired - Lifetime
- 1999-08-05 WO PCT/US1999/017220 patent/WO2000007583A2/en not_active Ceased
- 1999-08-05 CN CNB998117625A patent/CN1172663C/zh not_active Expired - Fee Related
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- 1999-08-05 AU AU55452/99A patent/AU772715B2/en not_active Ceased
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- 1999-08-05 DE DE69931789T patent/DE69931789T2/de not_active Expired - Lifetime
- 1999-08-05 JP JP2000563268A patent/JP2002522383A/ja active Pending
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