CA2336080A1 - N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders - Google Patents

Info

Publication number

CA2336080A1

CA2336080A1 CA002336080A CA2336080A CA2336080A1 CA 2336080 A1 CA2336080 A1 CA 2336080A1 CA 002336080 A CA002336080 A CA 002336080A CA 2336080 A CA2336080 A CA 2336080A CA 2336080 A1 CA2336080 A1 CA 2336080A1

Authority

CA

Canada

Prior art keywords

alkenyl

alkyl

straight

branched chain

thioester

Prior art date

1998-08-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 208000029257 vision disease Diseases 0.000 title claims abstract description 37
• 239000004202 carbamide Substances 0.000 title claims abstract description 30
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title claims abstract description 29
• -1 heterocyclic thioesters Chemical class 0.000 title claims description 270
• 230000004438 eyesight Effects 0.000 title claims description 52
• 208000026139 Memory disease Diseases 0.000 title 1
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 79
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• 230000004377 improving vision Effects 0.000 claims abstract description 16
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• 125000000217 alkyl group Chemical group 0.000 claims description 313
• 125000003342 alkenyl group Chemical group 0.000 claims description 306
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• 125000004432 carbon atom Chemical group C* 0.000 claims description 132
• 150000002148 esters Chemical class 0.000 claims description 97
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 93
• 125000003282 alkyl amino group Chemical group 0.000 claims description 83
• 150000001875 compounds Chemical class 0.000 claims description 77
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• 125000003545 alkoxy group Chemical group 0.000 claims description 73
• 125000004103 aminoalkyl group Chemical group 0.000 claims description 73
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 73
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 73
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• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 61
• 125000003396 thiol group Chemical group [H]S* 0.000 claims description 61
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• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 58
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• 229910052717 sulfur Inorganic materials 0.000 claims description 44
• 125000003118 aryl group Chemical group 0.000 claims description 42
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• 239000000203 mixture Substances 0.000 claims description 42
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 40
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
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• ZHUXMBYIONRQQX-UHFFFAOYSA-N hydroxidodioxidocarbon(.) Chemical compound [O]C(O)=O ZHUXMBYIONRQQX-UHFFFAOYSA-N 0.000 claims description 15
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