CA2335246A1 - Detection de cancers a l'aide de l'autofluorescence cellulaire - Google Patents

Detection de cancers a l'aide de l'autofluorescence cellulaire Download PDF

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Publication number
CA2335246A1
CA2335246A1 CA002335246A CA2335246A CA2335246A1 CA 2335246 A1 CA2335246 A1 CA 2335246A1 CA 002335246 A CA002335246 A CA 002335246A CA 2335246 A CA2335246 A CA 2335246A CA 2335246 A1 CA2335246 A1 CA 2335246A1
Authority
CA
Canada
Prior art keywords
tissue
light
accordance
intensity
fiber optic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002335246A
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English (en)
Inventor
Bhaskar Banerjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/097,931 external-priority patent/US6405074B1/en
Application filed by Individual filed Critical Individual
Publication of CA2335246A1 publication Critical patent/CA2335246A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4233—Evaluating particular parts, e.g. particular organs oesophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4318—Evaluation of the lower reproductive system
    • A61B5/4331—Evaluation of the lower reproductive system of the cervix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4375—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the male reproductive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Endoscopes (AREA)

Abstract

Cette invention concerne un appareil et des procédés qui sont notamment destinés à la détection de cancers à l'aide de l'autofluorescence cellulaire. Dans un mode de réalisation, l'appareil (10) comprend une source (12) de lumière blanche produisant un faisceau lumineux qui est transmis vers les tissus par l'intermédiaire d'un groupe (18) de fibres optiques faisant partie d'un faisceau de fibres optiques bidirectionnel (22). Le faisceau de fibres optiques bidirectionnel (22) peut être introduit dans un endoscope classique. Le faisceau lumineux va exciter les tissus et entraîner une émission d'autofluorescence cellulaire à une longueur d'onde d'environ 330 nm. Un échantillon lumineux réfléchi par les tissus est renvoyé à travers le faisceau de fibres optiques bidirectionnel (22) et passe par un photodétecteur (36). Le photodétecteur (36) va produire un signal qui représente l'intensité de l'autofluorescence cellulaire, et qui peut être transmis vers un moniteur (38) sous forme de réponse mesurée ou de forme d'onde. Cet appareil peut également comprendre un dispositif à couplage de charge ainsi que des systèmes d'imagerie vidéo afin de produire des images vidéo en temps réel des tissus que l'on examine.
CA002335246A 1998-06-16 1998-08-25 Detection de cancers a l'aide de l'autofluorescence cellulaire Abandoned CA2335246A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/097,931 US6405074B1 (en) 1997-08-29 1998-06-16 Detection of cancer using cellular autofluorescence
US09/097,931 1998-06-16
PCT/US1998/017597 WO1999065394A1 (fr) 1998-06-16 1998-08-25 Detection de cancers a l'aide de l'autofluorescence cellulaire

Publications (1)

Publication Number Publication Date
CA2335246A1 true CA2335246A1 (fr) 1999-12-23

Family

ID=22265822

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002335246A Abandoned CA2335246A1 (fr) 1998-06-16 1998-08-25 Detection de cancers a l'aide de l'autofluorescence cellulaire

Country Status (6)

Country Link
EP (1) EP1087698A4 (fr)
JP (1) JP2002518664A (fr)
CN (1) CN1301137A (fr)
AU (1) AU9119498A (fr)
CA (1) CA2335246A1 (fr)
WO (1) WO1999065394A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6364829B1 (en) 1999-01-26 2002-04-02 Newton Laboratories, Inc. Autofluorescence imaging system for endoscopy
EP1148810B1 (fr) 1999-01-26 2005-11-16 Newton Laboratories, Inc. Systeme d'imagerie a autofluorescence pour endoscopie
DE60014702T2 (de) * 1999-12-22 2006-02-02 Xillix Technologies Corp., Richmond Tragbares system zur ermittlung von hautanomalien
GB0030310D0 (en) * 2000-12-13 2001-01-24 Medical Res Council Apparatus and method for imaging a histological sample
US6636623B2 (en) * 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
CN100405976C (zh) * 2002-04-14 2008-07-30 王念勇 利用固有荧光诊断早期肿瘤的诊断仪
DE10255013B4 (de) * 2002-11-25 2004-12-09 Siemens Ag Verfahren und Vorrichtung zur Lokalisierung von Licht emittierenden Bereichen
EP1807000A1 (fr) * 2004-09-24 2007-07-18 Art Advanced Research Technologies Inc. Procede d'imagerie optique pour caracteriser des tissus
JP5698483B2 (ja) * 2010-09-22 2015-04-08 オリンパス株式会社 蛍光観察装置
WO2014014956A1 (fr) 2012-07-17 2014-01-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Imagerie classique pour le diagnostic de tissus
CN105748149B (zh) * 2016-04-20 2019-02-01 叶莹 一种用于癌症手术荧光导航和残癌示踪与清除的设备
CN106226275A (zh) * 2016-07-15 2016-12-14 上海交通大学 一种基于指甲自荧光作为检测脑卒中发病的生物标志物的检测方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5131398A (en) * 1990-01-22 1992-07-21 Mediscience Technology Corp. Method and apparatus for distinguishing cancerous tissue from benign tumor tissue, benign tissue or normal tissue using native fluorescence
CA2042075C (fr) * 1991-05-08 2001-01-23 Branko Palcic Systeme d'imagerie endoscopique
US5612540A (en) * 1995-03-31 1997-03-18 Board Of Regents, The University Of Texas Systems Optical method for the detection of cervical neoplasias using fluorescence spectroscopy

Also Published As

Publication number Publication date
CN1301137A (zh) 2001-06-27
AU9119498A (en) 2000-01-05
JP2002518664A (ja) 2002-06-25
EP1087698A1 (fr) 2001-04-04
WO1999065394A1 (fr) 1999-12-23
EP1087698A4 (fr) 2003-09-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued