CA2321262A1 - Proteines hybrides monovalentes, multivalentes et multimeres caracterisees par un domaine de liaison cmh (complexe majeur d'histocompatibilite), conjugues de ces proteines, et utilisations correspondantes - Google Patents
Proteines hybrides monovalentes, multivalentes et multimeres caracterisees par un domaine de liaison cmh (complexe majeur d'histocompatibilite), conjugues de ces proteines, et utilisations correspondantes Download PDFInfo
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- CA2321262A1 CA2321262A1 CA002321262A CA2321262A CA2321262A1 CA 2321262 A1 CA2321262 A1 CA 2321262A1 CA 002321262 A CA002321262 A CA 002321262A CA 2321262 A CA2321262 A CA 2321262A CA 2321262 A1 CA2321262 A1 CA 2321262A1
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
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- MXHCPCSDRGLRER-UHFFFAOYSA-N pentaglycine Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O MXHCPCSDRGLRER-UHFFFAOYSA-N 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
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- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
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- 229920000333 poly(propyleneimine) Polymers 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 108010048818 seryl-histidine Proteins 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 230000009131 signaling function Effects 0.000 description 1
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- 150000003384 small molecules Chemical class 0.000 description 1
- CBHOWTTXCQAOID-UHFFFAOYSA-L sodium ethane formaldehyde mercury(2+) molecular iodine 2-sulfidobenzoate Chemical compound [Na+].[Hg++].C[CH2-].II.C=O.[O-]C(=O)c1ccccc1[S-] CBHOWTTXCQAOID-UHFFFAOYSA-L 0.000 description 1
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- 150000003440 styrenes Chemical class 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
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- 238000000844 transformation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
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- 235000002374 tyrosine Nutrition 0.000 description 1
- 108010020532 tyrosyl-proline Proteins 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
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- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7535198P | 1998-02-19 | 1998-02-19 | |
US60/075,351 | 1998-02-19 | ||
PCT/US1999/003603 WO1999042597A1 (fr) | 1998-02-19 | 1999-02-19 | Proteines hybrides monovalentes, multivalentes et multimeres caracterisees par un domaine de liaison cmh (complexe majeur d'histocompatibilite), conjugues de ces proteines, et utilisations correspondantes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2321262A1 true CA2321262A1 (fr) | 1999-08-26 |
Family
ID=22125136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002321262A Abandoned CA2321262A1 (fr) | 1998-02-19 | 1999-02-19 | Proteines hybrides monovalentes, multivalentes et multimeres caracterisees par un domaine de liaison cmh (complexe majeur d'histocompatibilite), conjugues de ces proteines, et utilisations correspondantes |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1054984A1 (fr) |
JP (1) | JP2002504342A (fr) |
AU (1) | AU765378B2 (fr) |
BR (1) | BR9908082A (fr) |
CA (1) | CA2321262A1 (fr) |
IL (1) | IL137706A0 (fr) |
NZ (1) | NZ506071A (fr) |
WO (1) | WO1999042597A1 (fr) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0889964A1 (fr) | 1996-03-28 | 1999-01-13 | The Johns Hopkins University | Analogues solubles heterodimeres divalents et multivalents de proteines |
US6458354B1 (en) | 1996-03-28 | 2002-10-01 | The Johns Hopkins University | Molecular complexes which modify immune responses |
US6268411B1 (en) | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
EP1377609B1 (fr) * | 2001-03-14 | 2015-06-24 | Dako Denmark A/S | Nouvelles constructions de molecules mhc, methodes d'utilisation de ces constructions a des fins de diagnostic et de therapie et utilisations de molecules mhc |
GB0118532D0 (en) | 2001-07-30 | 2001-09-19 | Isis Innovation | Materials and methods relating to improved vaccination strategies |
US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
CA2486545A1 (fr) * | 2001-09-17 | 2003-03-27 | Nalan Utku | Peptides capables de moduler une reponse immunitaire |
US7175983B2 (en) | 2001-11-02 | 2007-02-13 | Abmaxis, Inc. | Adapter-directed display systems |
KR20050044857A (ko) * | 2001-11-16 | 2005-05-13 | 파멕사 에이/에스 | 무차별 t 세포 에피토프 삽입물을 갖는 멀티머 단백질의면역원성 모방체 |
GB2392158B (en) * | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
ES2559763T3 (es) * | 2002-09-10 | 2016-02-15 | Affimed Gmbh | Anticuerpo humano específico de CD3 con propiedades inmunosupresoras |
EP2204190A1 (fr) * | 2003-07-15 | 2010-07-07 | Chugai Seiyaku Kabushiki Kaisha | Production d'IgM par des cellules transformées et procédés pour la quantification de ladite production d'IgM |
WO2005037190A2 (fr) * | 2003-09-03 | 2005-04-28 | Dendritherapeutics, Inc. | Vaccins multiplex |
GB2408507B (en) * | 2003-10-06 | 2005-12-14 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof for specific targeting |
EP1688432B1 (fr) | 2003-10-09 | 2011-08-03 | Chugai Seiyaku Kabushiki Kaisha | Solution stabilisee a concentration elevee en igm |
GB2409456B (en) * | 2003-10-30 | 2006-01-04 | Proimmune Ltd | Oligomeric receptor ligand pair member complexes |
CA2595462A1 (fr) * | 2005-01-21 | 2006-07-27 | Nalan Utku | Molecules de fusion hla et utilisations associees |
US20140105980A1 (en) * | 2012-10-11 | 2014-04-17 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
EP2361930A3 (fr) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimeres du complexes peptide-cmh et leur utilisation dans des maladies infectieuses de borrelia |
EP2167537A2 (fr) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Procedes compiles pour analyser et trier des echantillons |
WO2009039854A2 (fr) | 2007-09-27 | 2009-04-02 | Dako Denmark A/S | Multimères cmh dans le diagnostic, le vaccin et le traitement de la tuberculose |
DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
US10722562B2 (en) | 2008-07-23 | 2020-07-28 | Immudex Aps | Combinatorial analysis and repair |
GB0817244D0 (en) | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
WO2010037402A1 (fr) | 2008-10-02 | 2010-04-08 | Dako Denmark A/S | Vaccins moléculaires contre les maladies infectieuses |
US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
EP2800582A1 (fr) * | 2012-01-06 | 2014-11-12 | Oregon Health & Science University | Constructions partielles de cmh et leurs procédés d'utilisation |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
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US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
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CN113528634A (zh) | 2012-08-14 | 2021-10-22 | 10X基因组学有限公司 | 微胶囊组合物及方法 |
US9540439B2 (en) | 2012-10-08 | 2017-01-10 | St. Jude Children's Research Hospital | Therapies based on control of regulatory T cell stability and function via a neuropilin-1:semaphorin axis |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
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TR201908418T4 (tr) | 2013-11-04 | 2019-07-22 | Uti Lp | Sürdürülebilir immünoterapi için yöntem ve kompozisyonlar. |
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PL3148580T3 (pl) | 2014-05-29 | 2021-07-12 | Macrogenics, Inc. | Trójswoiste cząsteczki wiążące, które wiążą się swoiście z wieloma antygenami nowotworowymi, i sposoby ich zastosowania |
EP4270006A3 (fr) | 2014-06-13 | 2024-01-10 | Immudex ApS | Détection générale et isolement de cellules spécifiques par liaison de molécules marquées |
KR20230070325A (ko) | 2014-06-26 | 2023-05-22 | 10엑스 제노믹스, 인크. | 개별 세포 또는 세포 개체군으로부터 핵산을 분석하는 방법 |
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EP3262407B1 (fr) | 2015-02-24 | 2023-08-30 | 10X Genomics, Inc. | Procédés et systèmes de traitement de cloisonnement |
KR20180011135A (ko) | 2015-05-06 | 2018-01-31 | 유티아이 리미티드 파트너쉽 | 지속 치료를 위한 나노입자 조성물 |
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MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
CN108431232B (zh) | 2015-12-04 | 2022-10-14 | 10X 基因组学有限公司 | 用于核酸分析的方法和组合物 |
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US11866465B2 (en) | 2017-04-27 | 2024-01-09 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
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US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
WO2019157529A1 (fr) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Procédés de caractérisation d'analytes multiples à partir de cellules individuelles ou de populations cellulaires |
WO2019195166A1 (fr) | 2018-04-06 | 2019-10-10 | 10X Genomics, Inc. | Systèmes et procédés de contrôle de qualité dans un traitement de cellules uniques |
US20220275043A1 (en) * | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
EP3898666A2 (fr) | 2018-12-17 | 2021-10-27 | Immudex ApS | Panneau comprenant des multimères de borrelia cmh |
US20220162695A1 (en) | 2020-11-20 | 2022-05-26 | Becton, Dickinson And Company | Use of dextramer in single cell analysis |
CA3215077A1 (fr) * | 2021-04-07 | 2022-10-13 | Thomas J. Malia | Multimeres de peptide-mhc-immunoglobuline et leurs procedes d'utilisation |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0889964A1 (fr) * | 1996-03-28 | 1999-01-13 | The Johns Hopkins University | Analogues solubles heterodimeres divalents et multivalents de proteines |
US6211342B1 (en) * | 1996-07-18 | 2001-04-03 | Children's Hospital Medical Center | Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function |
JP2000516470A (ja) * | 1996-08-16 | 2000-12-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 可溶性一価および多価mhcクラスii融合タンパク質およびそれらの使用 |
WO1999009064A1 (fr) * | 1997-08-19 | 1999-02-25 | Mount Sinai School Of Medicine Of New York University ; | Element de la classe ii du complexe majeur d'histocompatibilite portant un epitope/molecules chimeres d'immunoglobuline |
-
1999
- 1999-02-19 NZ NZ506071A patent/NZ506071A/en unknown
- 1999-02-19 EP EP99908272A patent/EP1054984A1/fr not_active Ceased
- 1999-02-19 CA CA002321262A patent/CA2321262A1/fr not_active Abandoned
- 1999-02-19 JP JP2000532537A patent/JP2002504342A/ja not_active Withdrawn
- 1999-02-19 WO PCT/US1999/003603 patent/WO1999042597A1/fr not_active Application Discontinuation
- 1999-02-19 AU AU27748/99A patent/AU765378B2/en not_active Ceased
- 1999-02-19 BR BR9908082-6A patent/BR9908082A/pt not_active IP Right Cessation
- 1999-02-19 IL IL13770699A patent/IL137706A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO1999042597A1 (fr) | 1999-08-26 |
JP2002504342A (ja) | 2002-02-12 |
IL137706A0 (en) | 2001-10-31 |
NZ506071A (en) | 2003-05-30 |
AU2774899A (en) | 1999-09-06 |
BR9908082A (pt) | 2000-10-31 |
WO1999042597A9 (fr) | 1999-11-04 |
EP1054984A1 (fr) | 2000-11-29 |
AU765378B2 (en) | 2003-09-18 |
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