CA2320960A1 - Optimisation des proprietes immunomodulatrices des vaccins genetiques - Google Patents
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- CA2320960A1 CA2320960A1 CA002320960A CA2320960A CA2320960A1 CA 2320960 A1 CA2320960 A1 CA 2320960A1 CA 002320960 A CA002320960 A CA 002320960A CA 2320960 A CA2320960 A CA 2320960A CA 2320960 A1 CA2320960 A1 CA 2320960A1
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- C40B40/00—Libraries per se, e.g. arrays, mixtures
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
L'invention concerne des techniques permettant d'obtenir des molécules pouvant moduler une réponse immunitaire et les molécules immunomodulatrices obtenues à l'aide de ces techniques. Ces molécules sont utiles, par exemple, dans la personnalisation d'une réponse immunitaire induite par un vaccin génétique pour un but désiré.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7429498P | 1998-02-11 | 1998-02-11 | |
US2176998A | 1998-02-11 | 1998-02-11 | |
US09/021,769 | 1998-02-11 | ||
US60/074,294 | 1998-02-11 | ||
PCT/US1999/003020 WO1999041368A2 (fr) | 1998-02-11 | 1999-02-10 | Optimisation des proprietes immunomodulatrices des vaccins genetiques |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2320960A1 true CA2320960A1 (fr) | 1999-08-19 |
Family
ID=26695070
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002320626A Abandoned CA2320626A1 (fr) | 1998-02-11 | 1999-02-10 | Vecteurs de vaccins mis au point par genie genetique |
CA002320431A Abandoned CA2320431A1 (fr) | 1998-02-11 | 1999-02-10 | Ciblage de vecteurs de vaccins genetiques |
CA002320960A Abandoned CA2320960A1 (fr) | 1998-02-11 | 1999-02-10 | Optimisation des proprietes immunomodulatrices des vaccins genetiques |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002320626A Abandoned CA2320626A1 (fr) | 1998-02-11 | 1999-02-10 | Vecteurs de vaccins mis au point par genie genetique |
CA002320431A Abandoned CA2320431A1 (fr) | 1998-02-11 | 1999-02-10 | Ciblage de vecteurs de vaccins genetiques |
Country Status (6)
Country | Link |
---|---|
EP (3) | EP1053312A2 (fr) |
JP (3) | JP2002503461A (fr) |
AU (3) | AU3291099A (fr) |
CA (3) | CA2320626A1 (fr) |
MX (3) | MXPA00007893A (fr) |
WO (3) | WO1999041402A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
EP1003531B1 (fr) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Procedes de preparation de constructions d'acides nucleiques |
WO1999021979A1 (fr) | 1997-10-28 | 1999-05-06 | Maxygen, Inc. | Vecteurs du papillomavirus humain |
EP1690868A1 (fr) | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modification du tropisme viral et de la diversité d'espèces hôte par recombinaison du génome viral |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
WO1999065927A2 (fr) | 1998-06-17 | 1999-12-23 | Maxygen, Inc. | Technique de production de polynucleotides aux caracteristiques souhaitees |
JP2002522072A (ja) | 1998-08-12 | 2002-07-23 | マキシジェン, インコーポレイテッド | 工業用化学薬品の製造のためのモノオキシゲナーゼ遺伝子のdnaシャッフリング。 |
AU6510799A (en) | 1998-10-07 | 2000-04-26 | Maxygen, Inc. | Dna shuffling to produce nucleic acids for mycotoxin detoxification |
AU1619400A (en) | 1998-11-10 | 2000-05-29 | Maxygen, Inc. | Modified adp-glucose pyrophosphorylase for improvement and optimization of plantphenotypes |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
EP1130093A1 (fr) | 1999-01-19 | 2001-09-05 | Maxygen, Inc. | Recombinaison d'acides nucléiques moyennant des oligonucléotides |
IL138206A (en) * | 1999-02-04 | 2011-06-30 | Verenium Corp | Methods for non-stochastic generation of progeny polypeptides and hybrid polynucleotides |
CA2361384A1 (fr) | 1999-02-11 | 2000-08-17 | Sun Ai Raillard | Spectrometrie de masse a haut rendement |
US6531316B1 (en) | 1999-03-05 | 2003-03-11 | Maxyag, Inc. | Encryption of traits using split gene sequences and engineered genetic elements |
MXPA02000840A (es) | 1999-07-22 | 2002-07-30 | Procter & Gamble | Variantes de proteasa de subtilisina que tienen substituciones de aminoacidos en regiones de epitopes definidas. |
AU5928100A (en) | 1999-07-22 | 2001-02-13 | Procter & Gamble Company, The | Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions |
CZ2002171A3 (cs) | 1999-07-22 | 2002-06-12 | The Procter & Gamble Company | Proteinázový konjugát, čistící prostředek a prostředek osobní péče |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
US7115712B1 (en) * | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
US6998263B2 (en) | 2000-02-09 | 2006-02-14 | Genvec, Inc. | Methods of preparing and using a viral vector library |
AU5995701A (en) * | 2000-05-26 | 2001-12-03 | Univ Australian | Synthetic peptides and uses therefore |
AUPQ776100A0 (en) | 2000-05-26 | 2000-06-15 | Australian National University, The | Synthetic molecules and uses therefor |
WO2002000717A2 (fr) | 2000-06-23 | 2002-01-03 | Maxygen, Inc. | Nouvelles molecules costimulatrices |
AU2001268716A1 (en) | 2000-06-23 | 2002-01-08 | Maxygen, Inc. | Novel chimeric promoters |
AU2001273009A1 (en) * | 2000-06-26 | 2002-01-08 | Maxygen, Inc. | Methods and compositions for developing spore display systems for medicinal and industrial applications |
US6858422B2 (en) | 2000-07-13 | 2005-02-22 | Codexis, Inc. | Lipase genes |
DE10060959A1 (de) * | 2000-12-06 | 2002-06-20 | Aventis Res & Tech Gmbh & Co | Verfahren zur Isolierung und Identifizierung von Effektoren |
EP1358322B1 (fr) * | 2001-02-02 | 2009-10-28 | Large Scale Biology Corporation | Procede destine a ameliorer la complementarite d'un heteroduplex |
AU2002309989A1 (en) | 2001-05-18 | 2002-12-03 | Rigel Pharmaceuticals, Incorporated | Directed evolution of protein in mammalian cells |
WO2003008436A2 (fr) * | 2001-07-19 | 2003-01-30 | Icogen Corporation | Procedes d'identification de composes de peptidyl interagissant avec des molecules cibles extracellulaires |
US7544669B2 (en) * | 2001-11-21 | 2009-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Polynucleotide therapy |
US7476390B2 (en) | 2002-02-26 | 2009-01-13 | Maxygen, Inc. | Flavivirus antigens |
ES2564570T3 (es) | 2002-03-01 | 2016-03-23 | Codexis Mayflower Holdings, Llc | Métodos, sistemas y software para la identificación de biomoléculas funcionales |
JP4851687B2 (ja) | 2002-03-09 | 2012-01-11 | マキシジェン, インコーポレイテッド | 定向進化のための交叉点の最適化 |
EP1497418B1 (fr) | 2002-04-19 | 2012-10-17 | Verenium Corporation | Phospholipases, acides nucleiques codant pour ces phosphalipases et methodes de fabrication et d'utilisation |
US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
AU2003304275A1 (en) | 2002-08-06 | 2005-01-21 | Pioneer Hi-Bred International, Inc. | Ap1 amine oxidase variants |
AU2003297155B2 (en) | 2002-12-16 | 2010-03-18 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant vaccine viruses expressing IL-15 and methods of using the same |
CN104388449A (zh) | 2003-03-06 | 2015-03-04 | 维莱尼姆公司 | 淀粉酶、编码它们的核酸及其制备和应用方法 |
CA2889013C (fr) | 2003-03-07 | 2018-07-17 | Dsm Ip Assets B.V. | Hydrolases, acides nucleiques les codant, et procedes de fabrication et d'utilisation correspondants |
US7592434B2 (en) | 2003-04-04 | 2009-09-22 | Verenium Corporation | Pectate lyases, nucleic encoding them and methods for making and using them |
CN1863914B (zh) | 2003-04-29 | 2011-03-09 | 先锋高级育种国际公司 | 新的草甘膦-n-乙酰转移酶(gat)基因 |
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
BRPI0412279A (pt) | 2003-07-02 | 2006-09-19 | Diversa Corp | glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos |
CA2535526C (fr) | 2003-08-11 | 2015-09-29 | Diversa Corporation | Laccases, acides nucleiques codant pour ces enzymes et procedes permettant de les produire et de les utiliser |
AR049214A1 (es) | 2004-06-09 | 2006-07-05 | Pioneer Hi Bred Int | Peptidos de transito a plastidos |
CN103173282A (zh) | 2004-06-16 | 2013-06-26 | 帝斯曼知识产权资产管理有限公司 | 对叶绿素进行酶促脱色的组合物和方法 |
GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
CA2614769A1 (fr) | 2005-03-10 | 2006-09-21 | Verenium Corporation | Lyases, acides nucleiques codant pour celles-ci et methodes de fabrication et d'utilisation |
CA2861310A1 (fr) | 2005-03-15 | 2006-09-28 | Bp Corporation North America Inc. | Cellulases, acides nucleiques codant pour ces cellulases, et procedes de production et d'utilisation de ces cellulases |
US8715988B2 (en) | 2005-03-28 | 2014-05-06 | California Institute Of Technology | Alkane oxidation by modified hydroxylases |
WO2007092314A2 (fr) | 2006-02-02 | 2007-08-16 | Verenium Corporation | Estérases, acides nucléiques apparentés et procédés associés |
DK2444487T3 (en) | 2006-02-10 | 2018-05-28 | Bp Corp North America Inc | CELLULOLYTIC ENZYMES, NUCLEIC ACIDS, CODING THEM, AND PROCEDURES FOR THEIR PREPARATION AND USE |
EP3406621A1 (fr) | 2006-02-14 | 2018-11-28 | BP Corporation North America Inc. | Xylanases, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation |
EA029538B1 (ru) | 2006-03-07 | 2018-04-30 | Басф Энзаймс Ллк | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
BRPI0708673A2 (pt) | 2006-03-07 | 2011-06-07 | Cargill Inc | método para fabricação de polipeptìdeos com atividade de aldolase e polinucleotìdeos que codificam estes polipeptìdeos |
AU2007356171B8 (en) | 2006-08-04 | 2014-01-16 | Bp Corporation North America Inc. | Glucanases, nucleic acids encoding them, and methods for making and using them |
WO2008036863A2 (fr) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phospholipases, acides nucléiques codant pour elles et leurs méthodes d'obtention et d'utilisation |
PL2617823T3 (pl) | 2006-09-21 | 2015-12-31 | Basf Enzymes Llc | Fitazy, kodujące je kwasy nukleinowe oraz sposoby ich wytwarzania i stosowania |
CA2982640A1 (fr) | 2006-12-21 | 2008-07-03 | Basf Enzymes Llc | Amylases et glucoamylases, acides nucleiques les codant, et leurs procedes de fabrication |
CN101652381B (zh) | 2007-01-30 | 2014-04-09 | 维莱尼姆公司 | 用于处理木质纤维素的酶、编码它们的核酸及其制备和应用方法 |
CN103757036B (zh) | 2007-10-03 | 2019-10-01 | 维莱尼姆公司 | 木聚糖酶、编码它们的核酸以及其制备和应用方法 |
EP2612868B1 (fr) | 2007-11-01 | 2018-08-15 | Astellas Pharma Inc. | Acides nucléiques et polypeptides immunosuppresseurs |
US8541220B2 (en) | 2008-01-03 | 2013-09-24 | Verenium Corporation | Isomerases, nucleic acids encoding them and methods for making and using them |
PL2238242T3 (pl) | 2008-01-03 | 2015-06-30 | Basf Enzymes Llc | Transferazy i oksydoreduktazy, kwasy nukleinowe kodujące je oraz sposoby ich wytwarzania i zastosowania |
BRPI0909611B8 (pt) | 2008-05-23 | 2022-12-06 | Pioneer Hi Bred Int | Método de aumento do teor total de ácido graxo de uma célula de oleaginosa, ácido nucleico recombinante, construção de dna recombinante e método de produção de uma semente oleaginosa |
US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
WO2010045002A2 (fr) | 2008-09-26 | 2010-04-22 | Tocagen Inc. | Vecteurs de thérapie génique et cytosines déaminases |
ES2607688T3 (es) | 2009-05-21 | 2017-04-03 | Basf Enzymes Llc | Fitasas, ácidos nucleicos que las codifican y métodos para su producción y uso |
CA2770854A1 (fr) | 2009-08-20 | 2011-02-24 | Pioneer Hi-Bred International, Inc. | Expression fonctionnelle d'un transporteur de nitrate de levure brasse (ynt1) chez le mais pour ameliorer l'absorption du nitrate dans un environnement pauvre en nitrate |
UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
WO2011082304A1 (fr) | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Modification génétique de la résistance de plantes à des maladies provoquées par des agents pathogènes |
BR112013003135A2 (pt) | 2010-08-13 | 2017-11-07 | Pioneer Hi Bred Int | polinucletídeo e polipeptídeo isolado ou recombinante, construto de ácido nucleico, célula, planta, explante vegetal, semente transgênica, método para produção de célula vegetal para controle de plantas daninhas e para detecção de um polipeptídeo hppd e um polinucleotídeo. |
WO2013166113A1 (fr) | 2012-05-04 | 2013-11-07 | E. I. Du Pont De Nemours And Company | Compositions et procédés comprenant des séquences ayant une activité de méganucléase |
BR112015023286A2 (pt) | 2013-03-14 | 2018-03-06 | Arzeda Corp | polipeptídeo recombinante com atividade da dicamba descarboxilase, construto de polinucleotídeo, célula, método de produção de uma célula hospedeira compreendendo um polinucleotídeo heterólogo que codifica um polipeptídeo tendo atividade da dicamba descarboxilase, método para descarboxilar dicamba, um derivado de dicamba ou um metabolito de dicamba, método para a detecção de um polipeptideo e método para a detecção da presença de um polinucleotideo que codifica um polipeptideo tendo atividade da dicamba descarboxilase |
US20160053277A1 (en) | 2013-03-14 | 2016-02-25 | Pioneer Hi-Bred International, Inc. | Compositions Having Dicamba Decarboxylase Activity and Methods of Use |
US10023877B2 (en) | 2013-03-15 | 2018-07-17 | Pioneer Hi-Bred International, Inc. | PHI-4 polypeptides and methods for their use |
EP3032942B1 (fr) | 2013-08-16 | 2020-03-11 | Pioneer Hi-Bred International, Inc. | Protéines insecticides et leurs procédés d'utilisation |
EP3043635B1 (fr) | 2013-09-13 | 2020-02-12 | Pioneer Hi-Bred International, Inc. | Protéines insecticides et leurs procédés d'utilisation |
WO2015120276A1 (fr) | 2014-02-07 | 2015-08-13 | Pioneer Hi Bred International Inc | Protéines insecticides et leurs procédés d'utilisation |
EP3102684B1 (fr) | 2014-02-07 | 2020-05-06 | Pioneer Hi-Bred International, Inc. | Protéines insecticides et leurs procédés d'utilisation |
CA2960102C (fr) * | 2014-09-11 | 2023-10-24 | Vlp Therapeutics, Llc | Particule pseudo-virale du flavivirus |
US10435706B2 (en) | 2014-10-16 | 2019-10-08 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EA038923B1 (ru) | 2015-03-11 | 2021-11-10 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидная днк-конструкция и способы её применения |
RU2017144238A (ru) | 2015-05-19 | 2019-06-19 | Пайонир Хай-Бред Интернэшнл, Инк. | Инсектицидные белки и способы их применения |
MX2018001523A (es) | 2015-08-06 | 2018-03-15 | Pioneer Hi Bred Int | Proteinas insecticidas derivadas de plantas y metodos para su uso. |
US20180325119A1 (en) | 2015-12-18 | 2018-11-15 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP3960863A1 (fr) | 2016-05-04 | 2022-03-02 | Pioneer Hi-Bred International, Inc. | Protéines insecticides et leurs procédés d'utilisation |
US11001858B2 (en) * | 2016-06-20 | 2021-05-11 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
EP3954202A1 (fr) | 2016-07-01 | 2022-02-16 | Pioneer Hi-Bred International, Inc. | Protéines insecticides issues de plantes et leurs procédés d'utilisation |
EP4050021A1 (fr) | 2016-11-01 | 2022-08-31 | Pioneer Hi-Bred International, Inc. | Protéines insecticides et leurs procédés d'utilisation |
CN110088123B (zh) | 2016-12-14 | 2023-10-20 | 先锋国际良种公司 | 杀昆虫蛋白及其使用方法 |
CA3046226A1 (fr) | 2016-12-22 | 2018-06-28 | Pioneer Hi-Bred International, Inc. | Proteines insecticides et leurs procedes d'utilisation |
WO2018148001A1 (fr) | 2017-02-08 | 2018-08-16 | Pioneer Hi-Bred International Inc | Associations insecticides de protéines insecticides d'origine végétale et leurs procédés d'utilisation |
EP3622076A1 (fr) | 2017-05-11 | 2020-03-18 | Pioneer Hi-Bred International, Inc. | Protéines insecticides et leurs procédés d'utilisation |
WO2020198731A2 (fr) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Anticorps modifiés |
US20230235352A1 (en) | 2020-07-14 | 2023-07-27 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4882278A (en) * | 1983-04-29 | 1989-11-21 | President And Fellows Of Harvard College | Non-toxinogenic vibrio cholerae mutants |
IL96475A0 (en) * | 1989-11-29 | 1991-08-16 | Innovative Tech Center | Chimeric proteins |
JPH08510639A (ja) * | 1993-04-19 | 1996-11-12 | メディソーブ・テクノロジーズ・インターナショナル・リミテッド・パートナーシップ | 細胞取込みと遺伝子発現の促進と標的化をもたらす接合体と核酸のカプセル化 |
SG54115A1 (en) * | 1993-04-27 | 1998-11-16 | Gerber Scient Products Inc | Thermal printing apparatus with improved power supply |
WO1994026787A1 (fr) * | 1993-05-07 | 1994-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Procede pour generer des bibliotheques d'anticorps de phages specifiques de types cellulaires |
SE9304060D0 (sv) * | 1993-12-06 | 1993-12-06 | Bioinvent Int Ab | Sätt att selektera specifika bakteriofager |
US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
EP0789774A2 (fr) * | 1994-10-03 | 1997-08-20 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Reponse immunitaire amelioree par l'introduction par recombinaison du gene de la cytokine et/ou du gene de la proteine co-stimulatrice b7 dans un systeme d'expression virale |
WO1996013250A1 (fr) * | 1994-10-27 | 1996-05-09 | Amgem Inc. | Compositions pour une assimilabilite accrue d'agents therapeutiques administres par voie orale |
CA2211993A1 (fr) * | 1995-01-31 | 1996-08-08 | The Rockefeller University | Identification de la proteine membranaire, integrale dec (cellules dendritiques et epitheliales, 205 kda), un recepteur a domaines lectiniques de type c, des acides nucleiques codant dec, ainsi que ses applications |
WO1997007128A1 (fr) * | 1995-08-21 | 1997-02-27 | Duke University | Procede pour accroitre la densite d'un antigene sur une cellule presentant un antigene |
WO1997011605A1 (fr) * | 1995-09-28 | 1997-04-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Stimulation de reponses immunes cellulaires par une imunisation genique ciblee utilisant un agent particulaire |
US6489145B1 (en) * | 1996-07-09 | 2002-12-03 | Diversa Corporation | Method of DNA shuffling |
WO1997032987A1 (fr) * | 1996-03-08 | 1997-09-12 | University Of Toronto | Procede et compositions nucleiques immunogenes codant pour des antigenes, et molecules co-stimulant l'immunisation |
US6096548A (en) * | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
-
1999
- 1999-02-10 CA CA002320626A patent/CA2320626A1/fr not_active Abandoned
- 1999-02-10 AU AU32910/99A patent/AU3291099A/en not_active Abandoned
- 1999-02-10 JP JP2000531550A patent/JP2002503461A/ja not_active Withdrawn
- 1999-02-10 JP JP2000531583A patent/JP2002503478A/ja not_active Withdrawn
- 1999-02-10 CA CA002320431A patent/CA2320431A1/fr not_active Abandoned
- 1999-02-10 EP EP99906948A patent/EP1053312A2/fr not_active Withdrawn
- 1999-02-10 MX MXPA00007893A patent/MXPA00007893A/es unknown
- 1999-02-10 MX MXPA00007889A patent/MXPA00007889A/es unknown
- 1999-02-10 AU AU26741/99A patent/AU2674199A/en not_active Abandoned
- 1999-02-10 AU AU26742/99A patent/AU2674299A/en not_active Abandoned
- 1999-02-10 WO PCT/US1999/003023 patent/WO1999041402A2/fr not_active Application Discontinuation
- 1999-02-10 EP EP99932508A patent/EP1056842A2/fr not_active Withdrawn
- 1999-02-10 CA CA002320960A patent/CA2320960A1/fr not_active Abandoned
- 1999-02-10 MX MXPA00007891A patent/MXPA00007891A/es unknown
- 1999-02-10 WO PCT/US1999/003020 patent/WO1999041368A2/fr not_active Application Discontinuation
- 1999-02-10 EP EP99906949A patent/EP1053343A2/fr not_active Withdrawn
- 1999-02-10 WO PCT/US1999/003022 patent/WO1999041369A2/fr not_active Application Discontinuation
- 1999-02-10 JP JP2000531549A patent/JP2002507392A/ja not_active Withdrawn
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
US7459158B2 (en) | 1998-11-02 | 2008-12-02 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
Also Published As
Publication number | Publication date |
---|---|
JP2002503461A (ja) | 2002-02-05 |
CA2320431A1 (fr) | 1999-08-19 |
WO1999041369A3 (fr) | 1999-09-23 |
CA2320626A1 (fr) | 1999-08-19 |
MXPA00007891A (es) | 2002-09-18 |
JP2002507392A (ja) | 2002-03-12 |
AU2674299A (en) | 1999-08-30 |
AU3291099A (en) | 1999-08-30 |
WO1999041368A2 (fr) | 1999-08-19 |
WO1999041402A2 (fr) | 1999-08-19 |
WO1999041402A3 (fr) | 1999-11-11 |
MXPA00007889A (es) | 2002-09-18 |
MXPA00007893A (es) | 2002-10-23 |
EP1053343A2 (fr) | 2000-11-22 |
WO1999041368A3 (fr) | 1999-12-16 |
AU2674199A (en) | 1999-08-30 |
EP1056842A2 (fr) | 2000-12-06 |
EP1053312A2 (fr) | 2000-11-22 |
WO1999041369A2 (fr) | 1999-08-19 |
JP2002503478A (ja) | 2002-02-05 |
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